Advances in Locoregional Therapies for Gastrointestinal Cancer Metastases

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 15 May 2026 | Viewed by 20

Special Issue Editor


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Guest Editor
Peritoneal Surface Malignancy Program, Division of Surgical Oncology, Department of Surgery, The University of Kansas Health System, Kansas City, MO 66160, USA
Interests: oncologic surgery; gastrointestinal cancers; peritoneal surface malignancies; cytoreductive surgery; heated intraperitoneal chemotherapy
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Special Issue Information

Dear Colleagues,

Paradoxically, as systemic therapy for metastatic gastrointestinal adenocarcinomas continues to significantly improve both in relation to safety and efficacy, the need for aggressive locoregional treatment for metastases has also risen. Despite this contradiction, from a basic and translation science perspective, it is vital to address these “escape” metastases, which, for a given patient, would have resisted traditional and novel more targeted systemic therapies. Fortunately, in the last decade, due to advances in interventional radiology, endoscopy, and radiation therapy, many different modality options have come to the forefront that do not involve invasive operations. However, aggressive and extensive surgical interventions are still often needed. Thankfully, with modern healthcare and our much-improved capabilities to rescue patients from major complications, even these more invasive options have evolved to become less morbid with low mortality rates. In this Special Issue, we hope to explore the rapidly evolving topic of locoregional therapies for metastases from gastrointestinal cancers.

Prof. Dr. Mazin Al-Kasspooles
Guest Editor

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Keywords

  • gastrointestinal cancer metastases
  • locoregional therapies
  • interventional radiology
  • endoscopy
  • radiation therapy
  • invasive operations
  • cytoreductive surgery (CRS)
  • intraperitoneal chemotherapy (IP)
  • heated intraperitoneal chemotherapy (HIPEC)
  • tumor debulking
  • stereotactic body radiation therapy (SBRT)
  • selective internal radiation therapy (SIRT)

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Published Papers

This special issue is now open for submission.
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