Gene Editing and Delivery for Cancer Therapy (2nd Edition)
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 15 May 2026 | Viewed by 33
Special Issue Editors
Interests: metastasis; molecular pathway; cancer models; metabolism; tumor microenvironment; drug screening and development
Special Issues, Collections and Topics in MDPI journals
Interests: drug delivery; lipid nanoparticles; gene editing; nanomedicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is a continuation of our previous Special Issue, “Gene Editing and Delivery for Cancer Therapy” (https://www.mdpi.com/journal/cancers/special_issues/Gene_Cancers).
Cancer is a leading cause of human death worldwide. In 2020, an estimated 19.3 million cancer cases and 10.0 million cancer deaths occurred. Due to population growth and aging, it is expected that there will be 27.5 million new cancer cases and 16.3 million cancer deaths by 2040. Gene therapy has great potential in the treatment of human cancers. However, it has achieved low success in clinical practice due to a lack of efficient in vivo gene editing and delivery systems. Therefore, revolutionizing new technologies in gene editing and engineering gene delivery systems that specifically target neoplastic tissue are critical to overcoming the current limitations in gene therapy. For this purpose, biodegradable lipid, polymer, and inorganic nanomaterials have been extensively explored as delivery vehicles for siRNA, mRNA, antisense oligonucleotides, CRISPR/Cas9, and more, holding great promise in improving gene silencing and genome editing in cancer tissues. Other such tools include oncolytic viruses, DNA/RNA nanostructures, therapeutic peptides and exosomes. Despite these important advancements, gene therapy still faces many challenges that prevent its successful clinical translation, including its efficacy, safety profiles and increasing manufacturing complexity. This Special Issue therefore seeks research papers, short communications, and review articles that focus on the novel design and applications of gene editing and delivery that can overcome significant barriers hindering the successful translation of gene therapy in cancer treatment.
Dr. Yong Teng
Dr. Yamin Li
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- gene therapy
- gene editing
- gene delivery
- oncolytic viruses
- nanomaterial
- peptides
- nanostructures
- exosomes
- translational science
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