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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Oral Microbiome and Its Link to Oral Cancer: Exploring the Role of Infectious Agents

edited by

Tomoaki Shintani

submission deadline 31 Mar 2026 | 1 articles | Viewed by 4429 | Submission Open

Keywords: oral microbiome; oral cancer; infectious agents; microbial dysbiosis; host– microbe interactions

(This special issue belongs to the Section Infectious Agents and Cancer)

The EGFR-Tyrosine Kinase Inhibitors (EGFR-TKIs) and Immune Checkpoint Inhibitors (ICIs) for Non-Small Cell Lung Cancer

edited by

Greta Alì

and

Maria Giovanna Mastromarino

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3850 | Submission Open

Keywords: non-small cell lung cancer; target therapy; EGFR-tyrosine kinase inhibitors; immunotherapy; immune checkpoint inhibitors; molecular analysis; surgery; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Development of Biomarkers and Antineoplastic Drugs in Solid Tumors

edited by

Rosa Falcone

, Sofia Verkhovskaia and Michela Roberto

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3297 | Submission Open

Keywords: solid tumors; drugs; biomarkers; immunotherapy; targeted therapy; artificial intelligence

(This special issue belongs to the Section Cancer Drug Development)

Intratumoral Heterogeneity in Brain Cancers

edited by Michael Oldham

submission deadline 31 Mar 2026 | 1 articles | Viewed by 3182 | Submission Open

Keywords: intratumoral heterogeneity; brain; clonal evolution; tumor microenvironment; multiomics

(This special issue belongs to the Section Molecular Cancer Biology)

Cancer Drug Discovery and Development: 2nd Edition

edited by Gary Piazza

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3077 | Submission Open

Keywords: signal transduction inhibitors; small-molecule inhibitors; antibodies; PROTOC; immunotherapy; medicinal chemistry; chemical optimization; high-throughput screening

(This special issue belongs to the Section Cancer Drug Development)

Cellular and Molecular Mechanisms of Malignant Nervous System Cancers

edited by

April Weissmiller

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2657 | Submission Open

Keywords: medulloblastoma; pediatric glioma; neuroblastoma; diagnosis and prognostic markers; IDH; TERT; and EGFR mutations; DNA methylation; treatment approaches and strategies (chemotherapy; radiation therapy; immunotherapy; and targeted therapy); resistance mechanisms; tumor microenvironment; molecular characteristics of tumor heterogeneity

(This special issue belongs to the Section Molecular Cancer Biology)

Minimally Invasive Therapies in Urologic Cancers

edited by Eric M. Walser and

Guglielmo Manenti

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2389 | Submission Open

Keywords: laparoscopic surgery; robotic-assisted surgery; ablation; high-intensity focused ultrasound; partial nephrectomy; minimally invasive procedures; urologic cancers

(This special issue belongs to the Section Methods and Technologies Development)

Neoadjuvant Chemoradiotherapy for Gastrointestinal Cancer

edited by Daniel Martin

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2263 | Submission Open

Keywords: gastrointestinal cancers; neoadjuvant chemoradiotherapy; rectal cancer; esophageal cancer; pancreatic cancer; gastric cancer; immunotherapy; precision medicine; image guided radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Multiple Myeloma: Diagnosis and Therapy

edited by

Yvonne A. Efebera

and

Nidhi Sharma

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2096 | Submission Open

Keywords: multiple myeloma; plasma cell disorders; relapsed and refractory multiple myeloma; blood and marrow transplant

(This special issue belongs to the Section Cancer Therapy)

The Role of Viruses in the Development of Cancer

edited by

George Eric Blair

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1950 | Submission Open

Keywords: DNA and RNA tumour viruses; HPV; EBV; KSHV; HCV; HBV; HTLV1; McPyV

(This special issue belongs to the Section Infectious Agents and Cancer)

Exercise Interventions for People Living with Cancer: Advances in Knowledge and Implementation

edited by

Lara Edbrooke

and Chris Swain

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1605 | Submission Open

Keywords: cancer; survivorship; exercise; physical activity; implementation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Modern Pathology, Artificial Intelligence and Personalized Therapy in Gastrointestinal Cancer

edited by Wenqing Cao

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1329 | Submission Open

Keywords: molecular pathology; biomarkers; digital pathology; targeted therapy; gastric cancer; colon; liver; pancreas

(This special issue belongs to the Section Cancer Therapy)

The Development of Immunotherapies to Treat Lymphoma

edited by

Christina Kalpadakis

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1324 | Submission Open

Keywords: lymphoma immunotherapy; CAR T-cell therapy; immune checkpoint inhibitors; monoclonal antibodies; personalized immunotherapy

Robotic and Thoracoscopic Surgery for Thoracic Oncology

edited by

Elisa Meacci

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1277 | Submission Open

Keywords: robotic-assisted thoracic surgery; video-assisted thoracoscopic surgery (VATS); lung cancer surgery; esophageal cancer; thymic tumors; minimally invasive surgery; pleural tumors; chest wall tumors; mediastinal surgery; thoracic oncology

(This special issue belongs to the Section Clinical Research of Cancer)

Genetic Alterations and the Tumor Microenvironment

edited by Shanye Yin

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1276 | Submission Open

Keywords: tumor microenvironment; cancer immunology; immune checkpoint blockade; somatic mutations; T cell signaling; immune evasion; macrophage polarization; cancer immunotherapy resistance; single-cell transcriptomics; spatial analysis

(This special issue belongs to the Section Tumor Microenvironment)

Novel Strategies to Fight Metastatic Breast Cancer

edited by

Fernando Schmitt

and

Nuno Vale

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1001 | Submission Open

Keywords: breast cancer; metastasis; targeted therapy; biomarkers; personalized medicine; prognosis

(This special issue belongs to the Section Molecular Cancer Biology)

Deep Learning and Radiomics for Cancer Diagnosis, Staging, and Treatment Response

edited by Mohamed Shehata,

Mostafa Elhosseini

Mahmoud Badawy

and Hanaa ZainEldin

submission deadline 31 Mar 2026 | 1 articles | Viewed by 854 | Submission Open

Keywords: radiomics; deep learning; cancer imaging; diagnosis; staging; treatment response; machine learning; medical image analysis; precision oncology; federated learning; AI in healthcare

(This special issue belongs to the Section Methods and Technologies Development)

Diagnosis and Therapy in Urothelial Cancer

edited by

Giuseppe Palermo

submission deadline 31 Mar 2026 | 1 articles | Viewed by 695 | Submission Open

Keywords: urothelial cancer; bladder cancer; biomarkers; robotic surgery; immunotherapy; upper tract urothelial carcinoma

(This special issue belongs to the Section Cancer Therapy)

Advances in the Management and Prognosis of Brain Metastases

edited by

Guixiang Liao

and

Muhammad Khan

submission deadline 31 Mar 2026 | Viewed by 479 | Submission Open

Keywords: immunotherapy; target therapy; stereotactic radiotherapy; prognosis; quality of life

(This special issue belongs to the Section Cancer Therapy)

Advances on Imaging and Treatment of Head and Neck Cancer

edited by Yading Yuan, Vishruta A. Dumane,

Haibo Lin

and Luqman Dad

submission deadline 31 Mar 2026 | Viewed by 446 | Submission Open

Keywords: head and neck cancer; medical imaging; robotic surgery; image-guided radiation therapy; proton radiotherapy; online adaptive radiotherapy; artificial intelligence; machine learning

(This special issue belongs to the Section Cancer Therapy)

Mastering the Immunosuppressive Tumor Microenvironment with Cancer Vaccines

edited by

Prem Prakash Kushwaha

submission deadline 31 Mar 2026 | 1 articles | Viewed by 442 | Submission Open

Keywords: tumor microenvironment; cancer vaccines; immunosuppression; immune modulation; checkpoint inhibitors; dendritic cell vaccines; T cell activation; personalized cancer immunotherapy; vaccine adjuvants; combination immunotherapy

(This special issue belongs to the Section Tumor Microenvironment)

Contemporary Lung Cancer Nodal Staging and Evolving Therapeutic Paradigms

edited by

Takahiro Nakajima

and George A. Eapen

submission deadline 31 Mar 2026 | Viewed by 410 | Submission Open

Keywords: ninth TNM classification; nodal staging; endoscopic/endobronchial ultrasound; neoadjuvant/adjuvant therapy; biomarker testing

(This special issue belongs to the Section Cancer Therapy)

State of the Art and Advances in Kaposi Sarcoma

edited by

Athanasia Tourlaki

submission deadline 31 Mar 2026 | Viewed by 352 | Submission Open

Keywords: Kaposi sarcoma; human herpes virus 8 (HHV-8); oncogenesis; chemotherapy; targeted therapy; immunotherapy

(This special issue belongs to the Section Clinical Research of Cancer)

Glioblastoma Stem Cells: Molecule Pathways and Cancer Therapy

edited by Shilpi Singh

submission deadline 31 Mar 2026 | Viewed by 335 | Submission Open

Keywords: glioblastoma; glioma stem cells; therapeutic resistance; tumor recurrence; tumor microenvironment; cellular and molecular pathways

(This special issue belongs to the Section Molecular Cancer Biology)

TGF-β Signaling in the Tumor Microenvironment: Dual Roles in Cancer Progression and Therapy

edited by

Byung-Gyu Kim

submission deadline 31 Mar 2026 | Viewed by 248 | Submission Open

Keywords: TGF-β signaling; tumor microenvironment; solid tumors; hematologic malignancies; immune modulation; therapeutic resistance; TGF-β pathway inhibitors; cancer immunotherapy

(This special issue belongs to the Section Tumor Microenvironment)

Imaging and Liquid Biopsy Biomarkers for Cancer Diagnosis and Treatment (2nd Edition)

edited by

Mark Jesus M. Magbanua

and

Wen Li

submission deadline 31 Mar 2026 | Viewed by 247 | Submission Open

Keywords: cancer imaging; liquid biopsy; cancer diagnosis; treatment response; prognosis; metastasis; circulating tumor cells; disseminated tumor cells; circulating tumor DNA; circulating tumor RNA

(This special issue belongs to the Section Methods and Technologies Development)

Pioneering Advances in Neurosurgical Oncology: From Innovative Techniques to Better Patient Outcomes

edited by

Oreste de Divitiis

and

Massimiliano Visocchi

submission deadline 31 Mar 2026 | Viewed by 237 | Submission Open

Keywords: endoscope; 3D exoscope; tractography MRI; molecular biomarkers; stem cells; transoral; cordomas; skullbase

(This special issue belongs to the Section Methods and Technologies Development)

miRNAs in Targeted Cancer Therapy

edited by Mustafa Özen

submission deadline 31 Mar 2026 | Viewed by 237 | Submission Open

Keywords: miRNA; micro-RNA; targeted therapy; cancer treatment; solid tumors; hematological malignancies; non-coding RNAs; epigenetic regulation; cancer therapeutics; gene therapy

(This special issue belongs to the Section Cancer Therapy)

Immune Landscape of Multiple Myeloma

edited by Muhamed Baljevic and

Shebli Atrash

submission deadline 31 Mar 2026 | Viewed by 223 | Submission Open

Keywords: myeloma; immune; T cells; therapy; fitness

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Proteomics in Skin Cancer: Recent Advances

edited by

Ali Azimi

and Beatrice Dyring-Andersen

submission deadline 31 Mar 2026 | Viewed by 221 | Submission Open

Keywords: proteomics; skin cancer; mass spectrometry; melanoma; non-melanoma skin cancers; biomarkers

(This special issue belongs to the Section Molecular Cancer Biology)

Flow Cytometry and Beyond: Innovative Cytometric Approaches in Cancer Detection, Profiling, and Therapeutic Monitoring

edited by

George Vartholomatos

Georgios Markopoulos

, Lefkothea Dova and Savvas Dimitriadis

submission deadline 31 Mar 2026 | Viewed by 220 | Submission Open

Keywords: cancer diagnostics; next-generation flow cytometry; AI-driven cytometry; high-dimensional single-cell analysis; cancer immunophenotyping; cytometry-based biomarkers; tumor heterogeneity; extracellular vesicles; spectral and mass cytometry; intraoperative flow cytometry

(This special issue belongs to the Section Methods and Technologies Development)

Mitochondrial Metabolism in Cancer Immune Responses

edited by

Jae Ho Seo

and Kiwon Lee

submission deadline 31 Mar 2026 | Viewed by 184 | Submission Open

Keywords: mitochondria; cancer metabolism; immune response; tumor microenvironment (TME); immunometabolism; mitochondrial reprogramming; reactive oxygen species (ROS); cancer immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Recent Advances in the Understanding of Myelodysplastic Syndrome and Acute Myeloid Leukemia (2nd Edition)

edited by

Ioannis Mitroulis

, Konstantinos Liapis and

Eleni Gavriilaki

submission deadline 31 Mar 2026 | Viewed by 180 | Submission Open

Keywords: myelodysplastic syndrome; acute myeloid leukemia; bone marrow micro-environment; targeted therapies; hematopoietic stem cell; leukemic stem cell; hematopoietic stem cell transplantation

(This special issue belongs to the Section Cancer Therapy)

Advances in Quantitative Imaging, AI, and Novel Imaging Techniques for Precision Radiology in Prostate Cancer

edited by Rulon R. Mayer,

Charles Simone

and

Yuan Yuan

submission deadline 31 Mar 2026 | Viewed by 174 | Submission Open

Keywords: prostate cancer; multi-parametric MRI (mpMRI); bi-parametric MRI; positron emission tomography (PET); computed tomography (CT); ultrasound (US); artificial intelligence (AI); convolutional neural network; visual language model; computer-aided diagnosis; spatially registered multi-parametric MRI; prostate specific membrane antigen in PET/CT

(This special issue belongs to the Section Methods and Technologies Development)

Proteomic and Oncogenic Biomarkers in Gastrointestinal Cancer

edited by

Marta Lukaszewicz-Zajac

and

Adrianna Romanowicz

submission deadline 31 Mar 2026 | Viewed by 167 | Submission Open

Keywords: tumor biomarkers; early detection; tumor progression; carcinogenesis; inflammatory mediators; gastrointestinal cancer; prognostic biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Screening and Surveillance of Gastrointestinal and Pancreatic Cancers

edited by Darina Kohoutová and

Jan Bures

submission deadline 31 Mar 2026 | Viewed by 156 | Submission Open

Keywords: screening; surveillance; GI cancer; pancreatic precancerous lesions

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Lipids and Small Metabolites in Cancer—2nd Edition

edited by

Zsolt Balogi

and

Laszlo Vigh

submission deadline 31 Mar 2026 | Viewed by 141 | Submission Open

Keywords: lipid; small metabolites; cancer; metabolome- and lipidome-related mechanisms; amino acids; fatty acids; numerous components of biochemical pathways

(This special issue belongs to the Section Molecular Cancer Biology)

Real-World Clinical Studies in Acute Leukemia

edited by

Anna Candoni

submission deadline 31 Mar 2026 | Viewed by 137 | Submission Open

Keywords: acute myeloid leukemia (AML); acute lymphoid leukemia (ALL); refractory/relapsed leukemia; target therapy; FLT3 inhibitors; IDH (1-2) inhibitors; venetoclax; hypomethylating agents; stem cell transplantation (SCT); minimal residual disease (MRD); MRD-driven therapy

(This special issue belongs to the Section Clinical Research of Cancer)

World Lung Cancer Awareness Month: 2nd Edition

edited by

Calvin Sze Hang Ng

submission deadline 31 Mar 2026 | Viewed by 135 | Submission Open

Keywords: lung cancer; tumor microenvironment; early detection; therapeutic targets; new therapeutic strategies; surgery; genetics

(This special issue belongs to the Section Cancer Therapy)

Clinical Research in Ocular Oncology

edited by Anthony Daniels,

Arun D. Singh

and

Jens Folke Kiilgaard

submission deadline 31 Mar 2026 | Viewed by 122 | Submission Open

Keywords: ocular oncology; eye cancer; tumors; melanoma; retinoblastoma; hemangioma; hemangioblastoma; lymphoma

(This special issue belongs to the Section Clinical Research of Cancer)

Modern Approaches in Gastrointestinal (GI) Oncology: From Bench to Bedside

edited by

Francesco Fiorica

submission deadline 31 Mar 2026 | Viewed by 122 | Submission Open

Keywords: gastrointestinal oncology; radiotherapy and immunotherapy; translational cancer research; radiogenomics and AI; biomarkers and personalized treatment

(This special issue belongs to the Section Cancer Therapy)

Biomarkers of Urological Cancers

edited by

Aristotelis Bamias

Michalis Liontos

and Zisis Kratiras

submission deadline 31 Mar 2026 | Viewed by 119 | Submission Open

Keywords: biomarkers; urothelial cancer; prostate cancer; renal cancer; checkpoint inhibitors; PD-L1; KIM-1; FGFR3; BRCA; HRD

(This special issue belongs to the Section Cancer Biomarkers)

Clinical and Surgical Outcomes in the Management of Extremity Soft Tissue Sarcomas (2nd Edition)

edited by

Matthew T. Houdek

submission deadline 31 Mar 2026 | Viewed by 119 | Submission Open

Keywords: soft tissue sarcoma; outcome; limb salvage; radiotherapy; surgery

(This special issue belongs to the Section Cancer Therapy)

Lung Cancer—Molecular Insights and Targeted Therapies (Third Edition)

edited by

Sonia Molina-Pinelo

submission deadline 31 Mar 2026 | Viewed by 108 | Submission Open

Keywords: lung cancer; non-small-cell lung cancer; small-cell lung cancer; biomarkers; oncogene-drive tumors; molecular mechanisms; targeted therapies; immunotherapy; precision medicine; preclinical models

(This special issue belongs to the Section Molecular Cancer Biology)

Novel Biomarkers and Dose-Response Modifiers in Radiation Oncology and Nuclear Medicine: Molecular Insights for Personalized Therapy and Precision Medicine

edited by

Wolfgang Sauerwein

and Andrea Wittig

submission deadline 31 Mar 2026 | Viewed by 85 | Submission Open

Keywords: targeted therapies; predictive essays; radiosensitizers; radioprotectors; theranostics; BNCT; alpha-immunotherapy; biological response modifiers; biomarkers

Gene Fusions in Cancer

edited by Christopher R. McEvoy and

Ing Soo Tiong

submission deadline 31 Mar 2026 | Viewed by 84 | Submission Open

Keywords: gene fusions; targeted therapy; cancer diagnostics; molecular pathology

(This special issue belongs to the Section Molecular Cancer Biology)

Chemoradiotherapy for Non-Small Cell Lung Cancer

edited by Carlo Greco

submission deadline 31 Mar 2026 | Viewed by 11 | Submission Open

Keywords: NSCLC; concurrent chemoradiotherapy; immunotherapy consolidation; adaptive radiotherapy; functional imaging; radiomics; biomarkers; re-irradiation; toxicity mitigation; AI decision support

(This special issue belongs to the Section Cancer Therapy)

Rare Tumors in Children: Trends in Diagnosis, Treatment and Prevention (2nd Edition)

edited by

Antonio Ruggiero

and

Stefano Mastrangelo

submission deadline 1 Apr 2026 | 3 articles | Viewed by 7028 | Submission Open

Keywords: pediatric oncology; pediatric drugs; clinical pharmacology

(This special issue belongs to the Section Pediatric Oncology)

Advances in Neuro-Oncological Imaging (2nd Edition)

edited by

Julia Furtner

and

Anna Sophie Berghoff

submission deadline 1 Apr 2026 | 2 articles | Viewed by 5495 | Submission Open

Keywords: central nervous system (CNS) tumors; brain tumors; spinal cord tumors; magnetic resonance imaging (MRI); positron emission tomography (PET); intraoperative MRI; imaging biomarkers; metabolic imaging; radiomics; machine learning

(This special issue belongs to the Section Methods and Technologies Development)

Application of Ultrasound in Cancer Diagnosis and Treatment

edited by Radu Ion Badea and Adrian Bartoș

submission deadline 1 Apr 2026 | 1 articles | Viewed by 2292 | Submission Open

Keywords: contrast-enhanced; ultrasound; elastography; intraoperative ultrasound; ultrasound-guided procedures; minimally invasive ultrasound; ultrasound-guided liver resections; ultrasound-guided tumoral ablations; liver tumors

(This special issue belongs to the Section Methods and Technologies Development)

Displaying special issue 401-450 on page 9 of 24.

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