Chemoradiotherapy for Non-Small Cell Lung Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 11
Special Issue Editor
2. Department of Radiation Oncology (Medicine and Surgery), Università Campus Bio-Medico di Roma, 00128 Rome, Italy
Interests: image-guided radiotherapy; adaptive planning; lung cancer; multimodal chemoradiotherapy; AI in radiation oncology
Special Issue Information
Dear Colleagues,
Concurrent chemoradiotherapy remains the backbone of curative-intent treatment for unresectable, locally advanced non-small cell lung cancer (NSCLC). Over the last decade, major advances—including immunotherapy consolidation, image-guided adaptive radiotherapy, and biological imaging—have reshaped standards of care and opened new avenues for personalization. Yet, relevant questions persist: how do we refine patient selection for chemo-immuno-radiotherapy; how do we integrate functional imaging, radiomics, and circulating biomarkers to predict benefit and toxicity; how do we optimize dose, fractionation, and target definition in the era of motion management, proton therapy, and stereotactic re-irradiation; and how do we translate AI-enabled decision support and digital twins into routine practice while preserving safety, equity, and value?
This Special Issue invites original research, clinical trials, meta-analyses, and authoritative reviews addressing clinical outcomes, toxicity mitigation, treatment planning innovations, biomarkers of response and resistance, and multimodal strategies (chemotherapy, immunotherapy, targeted agents) combined with radiotherapy. Contributions on adaptive workflows, re-irradiation, oligoprogression, patient-reported outcomes, and health-economics are particularly welcome. Our goal is to provide a rigorous, practice-shaping collection that advances precision chemoradiotherapy for NSCLC and informs future guidelines.
Dr. Carlo Greco
Guest Editor
Manuscript Submission Information
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Keywords
- NSCLC
- concurrent chemoradiotherapy
- immunotherapy consolidation
- adaptive radiotherapy
- functional imaging
- radiomics
- biomarkers
- re-irradiation
- toxicity mitigation
- AI decision support
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