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Application of Ultrasound in Cancer Diagnosis and Treatment

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 1 April 2026 | Viewed by 326

Special Issue Editors


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Guest Editor
1. Department of Medical Imaging, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania
2. “Prof. Dr. O. Fodor” Regional Institute of Gastroenterology and Hepatology, 400162 Cluj-Napoca, Romania
Interests: gastroenterology; ultrasonography; contrast; elastography; Doppler
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Institute of Advanced Studies in Science and Technology, Babeș-Bolyai University, Cluj-Napoca, Romania
2. Faculty of Medical and Health Sciences, Babeș-Bolyai University, Cluj-Napoca, Romania
3. Medicover Hospital, 407062 Cluj-Napoca, Romania
Interests: intraoperative ultrasound; interventional ultrasound; surgical oncology; robotic surgery; laparoscopic surgery

Special Issue Information

Dear Colleagues,

Ultrasound technology has revolutionized the landscape of cancer diagnosis and treatment, offering a non-invasive, cost-effective, and widely accessible approach for clinicians and patients alike. By utilizing high-frequency sound waves, ultrasound enables real-time imaging of soft tissue structures, allowing for the detection and characterization of tumors that may not be visible on traditional x-rays. Its high-resolution capabilities together with the use of contrast agents facilitate precise measurement of tumor size, assessment of vascularity, and differentiation between benign and malignant lesions. 

In clinical practice, ultrasound plays a pivotal role in guiding biopsies,  ensuring accurate sampling and minimizing procedural risks. Doppler ultrasound, contrast-enhanced ultrasound, and elastography further enhancediagnostic accuracy, helping to distinguish malignant from benign tissue. Beyond diagnosis, therapeutic applications such as High-Intensity Focused Ultrasound (HIFU), intraoperative ultrasound-guided surgery, ultrasound-guided tumor ablations, and ultrasound-guided drainages provide promising non-invasive treatment options, including in the field of minimally invasive surgery. As research advances, ultrasound continues to expand its utility in oncology, supporting early detection, personalized treatment strategies, and improved patient outcomes. This Special Issue highlights the latest developments and future directions in the application of ultrasound for cancer care.

Prof. Dr. Radu Ion Badea
Prof. Dr. Adrian Bartoș
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • contrast-enhanced
  • ultrasound
  • elastography
  • intraoperative ultrasound
  • ultrasound-guided procedures
  • minimally invasive ultrasound
  • ultrasound-guided liver resections
  • ultrasound-guided tumoral ablations
  • liver tumors

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Published Papers (1 paper)

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Review

33 pages, 3149 KB  
Review
High-Intensity Focused Ultrasound in Dermatology: A Review with Emphasis on Skin Cancer Management and Prevention
by Bartosz Woźniak, Piotr Sobolewski, Natalia Sauer, Mateusz Koper and Jacek Calik
Cancers 2025, 17(21), 3518; https://doi.org/10.3390/cancers17213518 - 31 Oct 2025
Viewed by 101
Abstract
High-intensity focused ultrasound (HIFU) has recently emerged as a novel non-invasive treatment modality in dermatology, offering precise ablation of cutaneous lesions with minimal damage to surrounding tissue. Originally developed for deep-seated tumors, dermatological HIFU platforms operating at ~20 MHz enable submillimeter-scale treatment of [...] Read more.
High-intensity focused ultrasound (HIFU) has recently emerged as a novel non-invasive treatment modality in dermatology, offering precise ablation of cutaneous lesions with minimal damage to surrounding tissue. Originally developed for deep-seated tumors, dermatological HIFU platforms operating at ~20 MHz enable submillimeter-scale treatment of thermal or mechanical injuries localized to the epidermis and superficial dermis, making them suitable for managing benign, premalignant, and malignant skin conditions. This review outlines the mechanistic basis of HIFU—including thermal coagulation, acoustic cavitation, and immunomodulatory effects—and presents the current evidence for its efficacy in treating actinic keratoses and basal cell carcinomas (BCCs), where early studies report clearance rates of 70–97% and excellent cosmetic outcomes. Compared to conventional therapies such as surgery, photodynamic therapy, or cryotherapy, HIFU offers reduced procedural pain, faster healing, and the ability to treat multiple lesions in a single session. Its role in field cancerization and potential utility in prophylaxis for high-risk skin areas are also explored. While promising, long-term oncologic outcomes and standardized treatment protocols remain under investigation. HIFU represents a significant advancement in non-invasive skin cancer management, aligning oncologic efficacy with patient-centered care. Full article
(This article belongs to the Special Issue Application of Ultrasound in Cancer Diagnosis and Treatment)
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