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Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genomic Instability: Insights into Molecular Mechanisms, Human Diseases, and Therapies
edited by
submission deadline 31 May 2026 | Viewed by 94 | Submission Open
Keywords: genome instability; DNA damage response; cancer; therapy; diagnosis
(This special issue belongs to the Section Molecular Genetics)
Molecular Mechanisms of Oocyte and Early Embryo Development: RNA Regulation and Epigenetic Modifications submission deadline 31 May 2026 | Viewed by 88 | Submission Open
Keywords: oocyte; embryo development; follicular development; RNA regulation; epigenetic modifications
(This special issue belongs to the Section Molecular Reproduction)
Molecular Research on Autoimmune Diseases: From Diagnosis to Therapy
edited by
submission deadline 31 May 2026 | Viewed by 82 | Submission Open
Keywords: systemic sclerosis; autoimmune diseases; rheumatic diseases; chronic inflammation; mechanisms
(This special issue belongs to the Section Biological Factors)
Molecular Motors in Muscle: From Single Molecules to Tissue Function
edited by
submission deadline 31 May 2026 | Viewed by 68 | Submission Open
Keywords: molecular motors; muscle mechanics; motor protein energetics; cytoskeletal dynamics; single-molecule biophysics  
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Skin Diseases: Molecular Pathogenesis and Therapeutic Approaches
edited by Georgios Gaitanis, and Achilleas Floudas
submission deadline 31 May 2026 | Viewed by 66 | Submission Open
Keywords: skin; pathophysiology; immunology; biochemistry; omics
(This special issue belongs to the Section Molecular Medicine)
Nitric Oxide and Reactive Species in Plant Physiology and Pathology
edited by
submission deadline 31 May 2026 | Viewed by 62 | Submission Open
Keywords: nitric oxide; reactive oxygen species; reactive sulfur species; redox signaling; S-nitrosylation; plant stress tolerance; antioxidant systems; phytohormones; metabolic regulation
(This special issue belongs to the Section Biological Factors)
Cellular Stress, Inflammation, and Metabolic Dysfunction in the Progression of MASLD
edited by Weber Andre Alberto
submission deadline 31 May 2026 | Viewed by 61 | Submission Open
Keywords: MASLD; fibrosis; liver; hepatosteatosis; endoplasmic reticulum stress
(This special issue belongs to the Section Molecular Medicine)
Genetic Variations and Gene Expression in Diseases
edited by
submission deadline 31 May 2026 | Viewed by 61 | Submission Open
Keywords: omics; gene expression; genetic variation; SNPs; polymorphisms; complex traits; monogenic disorders; gene-environment interactions; transcriptomics; functional analysis
(This special issue belongs to the Section Molecular Biology)
Advances in Cardiometabolic Health, 2nd Edition
edited by Pamela Senesi and
submission deadline 31 May 2026 | Viewed by 58 | Submission Open
Keywords: obesity; cardiovascular diseases; biomarkers; lifestyle interventions; personalized medicine
(This special issue belongs to the Section Cellular Biochemistry)
Bone Tissue Morphology: From Pathophysiological Mechanisms to Regenerative Strategies
edited by
submission deadline 31 May 2026 | Viewed by 54 | Submission Open
Keywords: osteoporosis; bone cancer; fracture repair; regenerative biomaterials; bone remodeling; molecular mechanisms; biomechanical mechanisms; bone imaging techniques
(This special issue belongs to the Section Molecular Medicine)
Current and Future Molecular Insights into Hematological Diseases: From Diagnosis to Therapy
edited by Miguel Piris-Villaespesa, and
submission deadline 31 May 2026 | Viewed by 49 | Submission Open
Keywords: hematological diseases; diagnostic assessment; molecular biology; targeted therapies; lymphoid neoplasm; myeloid neoplasm
(This special issue belongs to the Section Molecular Medicine)
Molecular Pathogenesis and Emerging Therapeutic Targets and Strategies in Huntington’s Disease
edited by and
submission deadline 31 May 2026 | Viewed by 35 | Submission Open
Keywords: Huntington’ s disease; huntingtin; polyglutamine; neurodegeneration; pathogenesis; therapeutic targets; proteopathy; autophagy dysfunction; transcriptional dysregulation; mitochondrial dysfunction
(This special issue belongs to the Section Molecular Medicine)
Advances in Nano-Based Drug Delivery Systems submission deadline 1 Jun 2026 | 5 articles | Viewed by 6640 | Submission Open
Keywords: drug delivery system; nanotechnology; nanomedicine; nanocarriers; nanoparticles; nanoformulation; biomolecules
(This special issue belongs to the Section Molecular Medicine)
Aldehyde Metabolism and Innate Immune Signaling in Cardiovascular Disease: From Pathogenesis to Regeneration
edited by Suresh S. Palaniyandi
submission deadline 1 Jun 2026 | Viewed by 80 | Submission Open
Keywords: reactive aldehydes (4-HNE; acrolein; and malondialdehyde); lipid peroxidation and oxidative stress; aldehyde detoxification enzymes (ALDH2; ALDHs; AKRs; and GSTs); glutathione and antioxidant defense systems; mitochondrial dysfunction and redox imbalance; protein adducts and cellular signaling; endothelial dysfunction and vascular injury; inflammation; innate immunity; and inflammasomes; cardiac remodeling; heart failure; and atherosclerosis; biomarkers and therapeutic strategies (enzyme activators; scavengers; and regeneration)
(This special issue belongs to the Section Molecular Medicine)
Emerging Bioactives from Underexplored Botanical Sources and By-Products for Food Applications
edited by Suelen Pereira Ruiz Herrig, Zilda Cristiani Gazim and Beatriz Cervejeira Bolanho Barros
submission deadline 1 Jun 2026 | Viewed by 72 | Submission Open
Keywords: botanical bioactives; by-products; natural food additives; green extraction
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Epigenetic Drivers of Cancer Metastasis: From Methylation to Non-Coding RNAs
edited by
submission deadline 19 Jun 2026 | 2 articles | Viewed by 1834 | Submission Open
Keywords: epigenetics; metastasis; DNA methylation; RNA methylation; non-coding RNAs
Cellular Stress Responses in Oncogenesis and Metabolic Reprogramming
edited by
submission deadline 19 Jun 2026 | Viewed by 131 | Submission Open
Keywords: cellular stress response; metabolic reprogramming; oncogenesis; lipid metabolism; tumor adaptation; mitochondrial metabolism
(This special issue belongs to the Section Cellular Biochemistry)
Advances in p53 Research submission deadline 20 Jun 2026 | 3 articles | Viewed by 15562 | Submission Open
Keywords: p53; small molecules; tumor suppressor; apoptosis; tumor– host interaction; targeted therapies; tumor microenvironment (TME)
(This special issue belongs to the Section Molecular Biology)
Molecular Biomarkers of Epileptogenesis submission deadline 20 Jun 2026 | 4 articles | Viewed by 13810 | Submission Open
Keywords: epileptogenesis; neuroinflammation; biomarkers; drug-resistant epilepsy; personalized neurology
(This special issue belongs to the Section Molecular Biomarkers)
Biochemistry and Molecular Biology of Vitamin D and Its Analog, 3rd Edition
edited by and Naoko Tsugawa
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1475 | Submission Open
Keywords: vitamin D; vitamin D receptor; vitamin D analog; genomic action; non-genomic action; bone formation; immune response; cancer; rickets; osteoporosis; psoriasis; drug discovery; disease prevention; nutrition improvement metabolism of vitamin D or its analogs cytochrome P450
(This special issue belongs to the Section Chemical Biology)
The Structure and Function of MHC Class I Molecules in Health and Disease: Implications in Aging and Neuro-Immune Crosstalk submission deadline 20 Jun 2026 | Viewed by 86 | Submission Open
Keywords: classical MHC-I molecules; human leukocyte antigen (HLA) class I; soluble HLA class I; immunological and non-immunological functions; neuro-immune crosstalk; aging and brain cognition
(This special issue belongs to the Section Cellular Biochemistry)
Oral Cancer: New Advances in Therapies
edited by , and Nicola Cirillo
submission deadline 20 Jun 2026 | Viewed by 78 | Submission Open
Keywords: oral cancer; targeted therapy; immunotherapy; biomarkers; tumor microenvironment; radiotherapy; chemotherapy; gene therapy; precision medicine; translational research
(This special issue belongs to the Section Molecular Medicine)
South American Native Species as Sources of Bioactive Compounds: Opportunities and Challenges
edited by Andressa Mara Baseggio and Maurício Ariel Rostagno
submission deadline 20 Jun 2026 | Viewed by 78 | Submission Open
Keywords: South American biodiversity; bioactive compounds; chemical characterization; health properties
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Molecular Mechanisms and Therapeutic Potential of Extracellular Vesicles in Neurovascular Diseases
edited by
submission deadline 20 Jun 2026 | Viewed by 55 | Submission Open
Keywords: extracellular vesicles; neurovascular diseases; cellular communications; biomarkers; therapeutic targets
(This special issue belongs to the Section Cellular Biochemistry)
Advances in Cellular and Molecular Mechanisms in Immuno-Oncology and Onco-Hematology: 2nd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 55 | Submission Open
Keywords: cancer immunotherapy; inhibitory immune checkpoints; CAR T cells; tumor immune evasion; cancer target therapy
(This special issue belongs to the Section Cellular Biochemistry)
WDFY1 in Immune Regulation and Disease: From Molecular Mechanisms to Therapeutic Applications
edited by Wenhai Shao
submission deadline 20 Jun 2026 | Viewed by 52 | Submission Open
Keywords: WDFY1; membrane tracking; TLR3; TLR4; autophagy; ubiquitination; lupus
(This special issue belongs to the Section Molecular Medicine)
Novel Signaling Pathways in Cardiometabolic Diseases
edited by
submission deadline 20 Jun 2026 | Viewed by 47 | Submission Open
Keywords: metabolic disorder; hypertension; stroke; cardiovascular disease; molecular mechanisms; hypertrophy; fibrosis; lipotoxiocity; mitochondrial function; inflammation
(This special issue belongs to the Section Biological Factors)
The Role of Nanoparticles in Tumor Treatment
edited by
submission deadline 25 Jun 2026 | 3 articles | Viewed by 11201 | Submission Open
Keywords: nanoparticles; cancer therapy; nanotechnology
(This special issue belongs to the Section Chemical Biology)
Pulmonary Fibrosis: From Molecular Mechanism to Therapeutic Targets
edited by Santosh Yadav, Muralidharan Anbalagan and Renat Shaykhiev
submission deadline 25 Jun 2026 | Viewed by 94 | Submission Open
Keywords: idiopathic pulmonary fibrosis; DNA damage response; senescence; immune checkpoint inhibitors
(This special issue belongs to the Section Molecular Medicine)
Intercellular Communication in Differentiation
edited by
submission deadline 25 Jun 2026 | Viewed by 24 | Submission Open
Keywords: intercellular communication; cellular differentiation; transcription factors; signaling hormone molecules
Plant Molecular Stress Physiology—Elucidation of Plant Responses and Defense Mechanisms Against Stress
edited by
submission deadline 26 Jun 2026 | 2 articles | Viewed by 1150 | Submission Open
Keywords: plant stress responses; biotic and abiotic stresses; molecular mechanisms of plant stress; plant defense mechanisms; stress tolerance in plants; signaling pathways in plant stress; gene-expression changes under stress; genomic tools for plant stress research; biotechnological approaches for stress-tolerant plants; adaptation strategies of plants to stress; physiological changes in plants under stress; crop resilience to stress; horticultural plant stress physiology; stress-related signaling molecules in plants; practical agricultural applications of stress research
(This special issue belongs to the Section Molecular Biology)
Molecular Genetics and Molecular Breeding in Plants: Advances, Applications, and Future Directions
edited by Yurong Xie and Hongbin Wei
submission deadline 26 Jun 2026 | 2 articles | Viewed by 1010 | Submission Open
Keywords: molecular genetics; molecular breeding; genome editing (CRISPR); omics technologies; stress resilience; trait discovery; genomic selection; sustainable agriculture; crop improvement; artificial intelligence in breeding
(This special issue belongs to the Section Molecular Genetics)
Design, Synthesis, and Therapeutic Applications of Heterocycles for Major and Neglected Diseases
edited by , and Arun Raja
submission deadline 26 Jun 2026 | Viewed by 189 | Submission Open
Keywords: heterocyclic compounds; medicinal chemistry; drug design; synthetic methodology; structure– activity relationship (SAR); major diseases; neglected tropical diseases; pharmacology
(This special issue belongs to the Section Chemical Biology)
Spotlight on Hot Cancer Biological Biomarkers submission deadline 30 Jun 2026 | 4 articles | Viewed by 9312 | Submission Open
Keywords: cancer biomarkers; precision medicine; liquid biopsy; imaging biomarkers; translational oncology
(This special issue belongs to the Section Molecular Biomarkers)
Mechanisms of Kidney Injury and Treatment Modalities
edited by Utpal Sen
submission deadline 30 Jun 2026 | 2 articles | Viewed by 7688 | Submission Open
Keywords: acute and chronic kidney injury; autophagy and mitophagy; bioenergetics; mitochondrial damage; and biogenesis; current therapeutic modalities and future strategies; epigenetic DNA methylation; histone modification; and non-coding RNAs and miRNAs; gaseous molecules and signaling pathways; gender differences; aging; and kidney dysfunction; glomerulosclerosis and renovascular remodelling following injury; gut– kidney axis and health; hypertensive; diabetic; and IgA nephropathy; inflammatory vs. reparatory macrophages and renal repair; ischemia and reperfusion injury; matrix protein; metalloproteinases; and their inhibitors; necrosis; necroptosis; apoptosis; pyroptosis; and ferroptosis; renal repair and regeneration
(This special issue belongs to the Section Molecular Biology)
Molecular Pathology, Diagnostics, and Therapeutics of Lung Disease
edited by
submission deadline 30 Jun 2026 | 4 articles | Viewed by 4205 | Submission Open
Keywords: pulmonary diseases; diagnostics; therapeutics
(This special issue belongs to the Section Molecular Medicine)
New Insights into Protein Aggregation in Condensed and Amyloid States submission deadline 30 Jun 2026 | 2 articles | Viewed by 4163 | Submission Open
Keywords: proteinopathies; protein aggregation; physico-chemical and biological properties of amyloid fibrils and protein condensates; signal and light transduction; interaction with lipid membranes; aggregating protein interactomes; bioinformatics and machine learning; molecular dynamics
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
The Biomarkers in Renal Diseases
edited by and María Carmen Ruiz Fuentes
submission deadline 30 Jun 2026 | 2 articles | Viewed by 3427 | Submission Open
Keywords: biomarkers; acute kidney injury; chronic kidney disease; microvesicles; exosomes
(This special issue belongs to the Section Molecular Biomarkers)
Advances in Pharmacognosy and Phytochemistry: From Molecular to Pre-Clinical Insights submission deadline 30 Jun 2026 | 1 articles | Viewed by 3043 | Submission Open
Keywords: metabolomics; drug discovery; phytopharmacology; medicinal plants
(This special issue belongs to the Section Natural and Bio-derived Molecules)
New Insights into Stem Cell-Derived Exosomes in Human Health and Disease
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 3041 | Submission Open
Keywords: stem cells; exosomes; regenerative medicine; diagnostics
(This special issue belongs to the Section Cellular Biochemistry)
Impact of Exercise Physiology and Diet on Adipokines in Health and Diseases
edited by Aurora Daniele and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2706 | Submission Open
Keywords: adipose tissue; adiponectin; adiponectin receptors; physical exercise; exercise; health; disease
(This special issue belongs to the Section Biological Factors)
Molecular Basis and Novel Treatment of Epilepsy
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2630 | Submission Open
Keywords: epilepsy; genetic basis; epileptogenesis; antiseizure drugs; novel treatment; translational research
(This special issue belongs to the Section Molecular Biology)
Bionanomaterials: Synthesis, Characterization, Toxicity and Biomedical Applications, 3rd Edition submission deadline 30 Jun 2026 | 2 articles | Viewed by 2407 | Submission Open
Keywords: nanoparticles; nano-alloys; graphene; nanotubes; hybrid nanomaterials; green synthesis; cytotoxicity; systemic toxicity; modulation of the biological impact; nanomaterials as diagnostic and therapeutic platforms; potential applications in medicine
(This special issue belongs to the Section Bio-Engineered Materials)
Mitochondria as a Target for Tissue Repair and Regeneration
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1731 | Submission Open
Keywords: mitochondria; trauma; tissue repair; regeneration; inflammation; mitochondrial DAMPs; mitochondrial biogenesis; mitophagy
(This special issue belongs to the Section Molecular Biology)
T Cell Ca2+ Signal Dynamics: An Emerging Landscape for Therapeutic Strategies
edited by David W. Thomas and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1564 | Submission Open
Keywords: T cell signaling; Ca signaling; TCR-activated signals; ER Ca release; ER Ca stores; store-operated Ca influx; ER Ca store depletion signals
(This special issue belongs to the Section Cellular Biochemistry)
Sperm Nuclear BASIC Proteins: From Chromatin Remodeling to Drug Development and Innovative Clinical Applications submission deadline 30 Jun 2026 | 1 articles | Viewed by 1536 | Submission Open
Keywords: sperm nuclear basic proteins (SNBPs); spermatogenesis; epigenetics; drug development; chromatin remodeling; biomarkers of fertility; translational reproductive medicine
(This special issue belongs to the Section Cellular Biochemistry)
Lipid Signaling in Human Disease
edited by and Felicity Ashcroft
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1391 | Submission Open
Keywords: lipid signaling pathways; membrane-derived lipid signaling molecules; inflammation mechanisms; cellular disease mechanisms; phospholipids; phospholipases; glycerophospholipids; sphingolipids
(This special issue belongs to the Section Lipids)
Design, Synthesis, and Evaluation of New Anticancer Substances and Radiopharmaceuticals
edited by and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1214 | Submission Open
Keywords: synthesis; anticancer activity; radiopharamceuticals; organic compounds; medicinal chemistry
(This special issue belongs to the Section Chemical Biology)
Immune Response to Allergens submission deadline 30 Jun 2026 | Viewed by 979 | Submission Open
Keywords: allergy; immune response; allergen; sensitization; molecular allergology; diagnostics; specific immunotherapy
(This special issue belongs to the Section Cellular Biochemistry)
Genetic Insights into Cardiomyopathy: From Mechanisms to Medicine
edited by Xiao Fan and Youngil Lee
submission deadline 30 Jun 2026 | 1 articles | Viewed by 814 | Submission Open
Keywords: cardiomyopathy; genetics; epigenetics; genomics; genotype– phenotype correlation; genetic penetrance; precision medicine; mitochondria; personalized treatment; gene therapy
(This special issue belongs to the Section Molecular Genetics)
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