Molecular Biomarkers of Epileptogenesis
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biomarkers".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 2211
Special Issue Editor
Special Issue Information
Dear Colleagues,
Epileptogenesis is the process by which a normal neural network becomes hyperexcitable and capable of causing seizures of epilepsy on its own.
Numerous research studies have examined the potential involvement of neuroinflammation in epileptogenesis in recent years. In this condition, the blood–brain barrier's permeability may be compromised, and aberrant angiogenesis may result from inflammatory mediators. Thus, it is closely linked to epileptogenesis, even though the molecular mechanisms underlying these pathophysiological processes are not fully understood.
On the other hand, unregulated focal or systemic inflammatory processes cause the creation of abnormal neuronal connections and hyperexcitable neural networks, as well as an altered response to neurotransmitters, all of which contribute to epileptogenesis.
For both reasons, over the recent two decades, there has been a growing number of both clinical and basic studies providing strong support for the notion that neuroinflammation is involved in epileptogenesis.
Lastly, understanding the process of epileptogenesis may also be aided by the role of cytokines as putative pro-inflammatory mediators in the neuropathology of epilepsy. Therefore, the activation of multiple pro- and anti-epileptogenic immune pathways is indicated by the upregulation of several of these inflammatory mediators in the neocortex and hippocampal regions of epileptic patients.
Given the boiling state of research into all these neuroinflammatory mechanisms of epileptogenesis, we believe that it may be a good time to launch a Special Issue of Biomolecules aimed at encouraging groups related to these lines of research to disseminate their findings. Therefore, this is the aim of this Special Issue.
Dr. Pedro J. Serrano-Castro
Guest Editor
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Keywords
- epileptogenesis
- neuroinflammation
- biomarkers
- drug-resistant epilepsy
- personalized neurology
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