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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Nonalcoholic Fatty Liver Disease: From Molecular Mechanisms to Therapeutic Approaches

edited by

Yumin Dai

and

Martina Beretta

submission deadline 31 Oct 2025 | 3 articles | Viewed by 5640 | Submission Open

Keywords: nonalcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); reactive oxygen species; mitochondria; lipotoxicity

(This special issue belongs to the Section Molecular Medicine)

Application of Bioinformatics in Medicine

edited by

Le Zhang

submission deadline 31 Oct 2025 | 3 articles | Viewed by 5112 | Submission Open

Keywords: computer-aided drug design (CADD); bioinformatics; systems medicine; drug discovery; computational biology

(This special issue belongs to the Section Bioinformatics and Systems Biology)

New Insights into the Membranes of Anoxygenic Phototrophic Bacteria

edited by

Robert A. Niederman

submission deadline 31 Oct 2025 | 3 articles | Viewed by 4910 | Submission Open

Keywords: anoxygenic phototrophs; light harvesting; membrane dynamics; molecular evolution; reaction centers

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Bioactive Molecules in the Control of Oxidative Stress and Oxidative Stress-Related Diseases

edited by

Jian Yao

submission deadline 31 Oct 2025 | 2 articles | Viewed by 4335 | Submission Open

Keywords: antioxidants; bioactive molecules; ROS; redox signaling; oxidative stress-related diseases

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in RNA Editing and Modification

edited by

Toshifumi Tsukahara

submission deadline 31 Oct 2025 | 2 articles | Viewed by 3382 | Submission Open

Keywords: RNA editing; RNA modification; deamination; transamination; pseudouridylation

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Nanoparticles for Cancer Therapy: Challenges and Opportunities

edited by

Nagavendra Kommineni

and

Venkatesh Pooladanda

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2797 | Submission Open

Keywords: nanoparticles; cancer; nanotheranostics; drug delivery; gene delivery

(This special issue belongs to the Section Bio-Engineered Materials)

Applications of Biomaterials in Medicine and Healthcare

edited by

Patrícia Alves

and

Paula Ferreira

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1953 | Submission Open

Keywords: biomaterials; tissue engineering; biomedical applications; drug delivery systems; medical implants

Molecular and Cellular Mechanisms of Kidney Diseases

edited by

Theodoros Eleftheriadis

and Maria Divani

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1791 | Submission Open

Keywords: chronic kidney disease; acute kidney injury; kidney transplantation; glomerular diseases; ischemia– reperfusion injury; diabetic nephropathy

(This special issue belongs to the Section Molecular Biology)

Crosstalk Between the Immune and Nervous Systems

edited by

Fuminori Tsuruta

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1530 | Submission Open

Keywords: microglia; astrocytes; macrophages; cerebral blood vessels; cerebrospinal fluid (CSF); meninges; immune cells; neuroinflammation; neurodegenerative disorders; psychiatric disorders

(This special issue belongs to the Section Molecular Biology)

The Biomarkers in Renal Diseases

edited by

Rosemary Wangensteen

and María Carmen Ruiz Fuentes

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1417 | Submission Open

Keywords: biomarkers; acute kidney injury; chronic kidney disease; microvesicles; exosomes

(This special issue belongs to the Section Molecular Biomarkers)

Cutting-Edge Perspectives on Protein and Enzyme Engineering

edited by Haishan Qi and Haoran Yu

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1187 | Submission Open

Keywords: protein engineering; protein material; enzyme evolution; therapy protein; protein expression; machine learning; unnatural amino acids

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Inflammation and Hemostasis: 2nd Edition

edited by

Zsuzsa Bagoly

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1161 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

Spotlight on Hot Cancer Biological Biomarkers

edited by

Dania Cioni

and

Salvatore Claudio Fanni

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1108 | Submission Open

Keywords: cancer biomarkers; precision medicine; liquid biopsy; imaging biomarkers; translational oncology

(This special issue belongs to the Section Molecular Biomarkers)

Recent Advances in Molecular Genetics of Bacteria

edited by Bin Jia

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1037 | Submission Open

Keywords: bacterial gene regulation; CRISPR-Cas systems; bacterial resistance; microbial genomics; genome-wide association studies; bacterial pathogenesis; genetic diversity

(This special issue belongs to the Section Molecular Genetics)

Homocysteine and H₂S in Health and Disease, 2nd Edition

edited by

Anton Hermann

and

Guzel F. Sitdikova

submission deadline 31 Oct 2025 | 1 articles | Viewed by 976 | Submission Open

Keywords: homocysteine (Hcy); hydrogen sulfide (H2S); oxidative stress; inflammation

(This special issue belongs to the Section Chemical Biology)

Molecular Basis and Novel Treatment of Epilepsy

edited by

Fang Zheng

submission deadline 31 Oct 2025 | 1 articles | Viewed by 907 | Submission Open

Keywords: epilepsy; genetic basis; epileptogenesis; antiseizure drugs; novel treatment; translational research

(This special issue belongs to the Section Molecular Biology)

Genetics and Epigenetics of Breast Cancer

edited by

Ashakumary Lakshmikuttyamma

submission deadline 31 Oct 2025 | 1 articles | Viewed by 810 | Submission Open

Keywords: breast cancer; genetic landscape; epigenetics; diagnostic/prognostic/predictive biomarkers

(This special issue belongs to the Section Molecular Genetics)

DNA Damage Repair and Cancer Therapeutics

edited by

Wenjing Li

submission deadline 31 Oct 2025 | 1 articles | Viewed by 767 | Submission Open

Keywords: DNA damage repair; cancer therapy; genomic stability; targeted therapy; biomarkers

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Involved Biomolecules Within Lysosomal Energy Sensing in Health and Disease

edited by Xianrui Yang and

L. Shannon Holliday

submission deadline 31 Oct 2025 | 1 articles | Viewed by 744 | Submission Open

Keywords: lysosomal energy sensing; vacuolar H+-ATPase (V-ATPase); 5’ -AMP-activated kinase (AMPK); mammalian target of rapamycin (mTor); sirtuin; aldolase; TRPV1; metformin; rapamycin

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Mechanisms and Signaling Pathways in Autoimmune Diseases

edited by

Daniele Saverino

submission deadline 31 Oct 2025 | 1 articles | Viewed by 644 | Submission Open

Keywords: autoimmune diseases; molecular mechanisms; signaling pathways; therapeutic targets; biomarkers

(This special issue belongs to the Section Molecular Biology)

Advancing Innovations in Biomedical Research for Translational Applications

edited by Jianjie Ma, Ki Ho Park and

Zui Pan

submission deadline 31 Oct 2025 | 1 articles | Viewed by 468 | Submission Open

Keywords: nanoparticle drug delivery; precision medicine; stem cell; proteomic and lipidomic profiling; novel therapeutic strategies; regenerative medicine; biologic drug development; IND submission

(This special issue belongs to the Section Molecular Medicine)

Immune Response to Allergens

edited by

Brigita Gradauskiene

submission deadline 31 Oct 2025 | Viewed by 369 | Submission Open

Keywords: allergy; immune response; allergen; sensitization; molecular allergology; diagnostics; specific immunotherapy

(This special issue belongs to the Section Cellular Biochemistry)

Food, Microbe, Viral and Parasite-Derived Antibodies in Autoimmune and Chronic Diseases

edited by

Phaedra Eleftheriou

submission deadline 31 Oct 2025 | Viewed by 366 | Submission Open

Keywords: food antigens; antigens; auto-antigens; antibodies; auto-antibodies; auto-immune diseases; chronic diseases; microbes; bacteria; fungi; virus; parasites; cross-reaction; infection; chronic diseases

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Studies of Protein Dynamics Using Fluorescence Correlation Spectroscopy (FCS)

edited by Jieqiong Lou and Elvis Pandžić

submission deadline 31 Oct 2025 | Viewed by 327 | Submission Open

Keywords: protein dynamics; Fluorescence Correlation Spectroscopy (FCS); protein interactions; subcellular environments; Image Correlation Spectroscopy(ICS) and extensions

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Molecular Mechanism and Regulation of Adipogenesis, Adipose Tissue Inflammation and Metabolism

edited by Udai P Singh

submission deadline 31 Oct 2025 | Viewed by 196 | Submission Open

Keywords: immunometabolism; obesity; adipogenesis; adipose tissue inflammation; adipose immune microenvironment; immune-adipose tissue cross-talk; hormones; high-fat diet; metabolic disease

(This special issue belongs to the Section Biological Factors)

Biochemistry and Molecular Biology of Vitamin D and Its Analog, 3rd Edition

edited by

Toshiyuki Sakaki

and Naoko Tsugawa

submission deadline 31 Oct 2025 | Viewed by 157 | Submission Open

Keywords: vitamin D; vitamin D receptor; vitamin D analog; genomic action; non-genomic action; bone formation; immune response; cancer; rickets; osteoporosis; psoriasis; drug discovery; disease prevention; nutrition improvement metabolism of vitamin D or its analogs cytochrome P450

(This special issue belongs to the Section Chemical Biology)

Assembly of RNA and DNA

edited by

Roman Marks

and

Jürg Bähler

submission deadline 31 Oct 2025 | Viewed by 143 | Submission Open

Keywords: polymerization of RNA and DNA; electrical functioning of RNA/DNA; rotational– electric principles of replication; interactions between RNA/DNA and physical/chemical field; chirality in biomolecules

(This special issue belongs to the Section Molecular Genetics)

Biomarkers in Neurodegenerative Diseases: Shaping the Future of Diagnosis and Treatment

edited by

Martine Tétreault

and

Laura Hamilton

submission deadline 31 Oct 2025 | Viewed by 126 | Submission Open

Keywords: molecular diagnostics; lipidomics; genomics; proteomics; transcriptomics

(This special issue belongs to the Section Molecular Biomarkers)

Advances in Metabolomics in Health and Disease

edited by

Carmen Socaciu

submission deadline 31 Oct 2025 | Viewed by 101 | Submission Open

Keywords: metabolomics; disease biomarkers; metabolic phenotyping; metabolic pathways; mass spectrometry; NMR spectroscopy; metabolic databases; bioinformatics

(This special issue belongs to the Section Molecular Medicine)

Obesity, Hormones and Reproductive Health

edited by

Srinivas Nammi

submission deadline 31 Oct 2025 | Viewed by 93 | Submission Open

Keywords: obesity; leptin; insulin; estrogens; androgens; growth hormone; sexual dysfunction; reproductive health

(This special issue belongs to the Section Biological Factors)

Soft Matter and Self-Assembly: From Biomaterials to Nanomaterials

edited by Caterina Ricci and

Maria Grazia Ortore

submission deadline 31 Oct 2025 | Viewed by 72 | Submission Open

Keywords: soft matter; self-assembly; biomaterials; nanomaterials; bioinspired materials; drug delivery; responsive materials; tissue engineering; nanotechnology; molecular organization

Ferroptosis and Cuproptosis: Mechanism and Crosstalk in Cancer, Neurodegeneration, and Metabolic Syndrome

edited by

Rosanna Squitti

submission deadline 31 Oct 2025 | Viewed by 72 | Submission Open

Keywords: ferroptosis; cuproptosis; Alzheimer's disease; colorectal cancer; neurodegeneration; metabolic syndrome; regulated cell death; iron metabolism; copper metabolism; psychiatric disorders

(This special issue belongs to the Section Molecular Medicine)

The Role of Amyloid in Neurological Disorders: 2nd Edition

edited by

Marny Fedrigo

and Tamara Berno

submission deadline 31 Oct 2025 | Viewed by 54 | Submission Open

Keywords: amyloid-beta; neurodegenerative disorders; aducanumab; oligomers; cross-amyloid interaction

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Botanic Metabolites: From Extraction to Application

edited by

Carmen Formisano

submission deadline 31 Oct 2025 | Viewed by 51 | Submission Open

Keywords: medicinal plants; phytochemistry; antimicrobial activity; plant extracts; essential oils; synergism

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Genetics and Cell Biology in Neuroblastoma

edited by

Dirk Geerts

submission deadline 31 Oct 2025 | Viewed by 45 | Submission Open

Keywords: genetics; genomics; neuroblastoma; precision medicine; transcriptomics

(This special issue belongs to the Section Cellular Biochemistry)

Computational Design and Mechanistic Studies of Metal-Based Therapeutics

edited by

Iogann Tolbatov

and

Andrea Melchior

submission deadline 1 Nov 2025 | Viewed by 98 | Submission Open

Keywords: anticancer metal complexes; antitumor metallodrugs; antimicrobial agents; antiviral metallodrugs; medicinal inorganic chemistry; bioinorganic chemistry; computational design; mechanistic studies; rational drug development

Transcription Factors in Hematopoiesis and Immunity: From Development to Therapeutic Targeting

edited by Amiya Kumar Patra

submission deadline 1 Nov 2025 | Viewed by 85 | Submission Open

Keywords: transcription factors; immune regulation; epigenetics; cytokines and chemokines; molecular interaction; immunodeficiency; allergy; leukemia and lymphoma; small molecule inhibitors; hematopoietic disorders

(This special issue belongs to the Section Molecular Biology)

Zebrafish Models in Cardiovascular and Metabolic Precision Medicine

edited by

Angom Ramcharan Singh

submission deadline 7 Nov 2025 | Viewed by 62 | Submission Open

Keywords: zebrafish models; cardiovascular disease; metabolic disorders; precision medicine; genetic screening; drug discovery; disease modeling; translational research; personalized therapy; high-throughput screening

Protein Structure Prediction in Drug Discovery: 2nd Edition

edited by

Alessandro Paiardini

submission deadline 15 Nov 2025 | 5 articles | Viewed by 25512 | Submission Open

Keywords: protein structure prediction; drug design; docking; virtual screening; drug discovery; machine learning; alphafold

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Advances in Neuroproteomics

edited by

Kenneth R. Williams

and

Angus C. Nairn

submission deadline 15 Nov 2025 | 9 articles | Viewed by 23983 | Submission Open

Keywords: discovery mass spectrometry; neuroproteomics; mass spectrometry; quantitative proteomics; targeted mass spectrometry

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Interface of Aging and Biomaterials: 2nd Edition

edited by

Joshua T. Morgan

submission deadline 15 Nov 2025 | 3 articles | Viewed by 11158 | Submission Open

Keywords: aging; senescence; geroscience; biomolecules; biomaterials; biocompatibility; nanoparticles; hydrogels

(This special issue belongs to the Section Bio-Engineered Materials)

Recent Advances in Mass Spectrometry-Based Proteomics

edited by

An Staes

and Simon Devos

submission deadline 15 Nov 2025 | Viewed by 80 | Submission Open

Keywords: LC-MS/MS proteomics; high-throughput; low input proteomics; clinical proteomics; spatial proteomics; immunopeptidomics; post-translational protein modifications; biomarker discovery; drug targets

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Structural Proteomics–Structural Biology Led by Advancements in Mass Spectrometry Techniques

edited by

Rohit Jain

, Corie Ralston and

Gang (Gary) Ren

submission deadline 20 Nov 2025 | 2 articles | Viewed by 5285 | Submission Open

Keywords: hydroxyl radical protein footprinting MS (XFP; FPOP); hydrogen/deuterium exchange MS (HDX-MS); cross-linking MS (XL-MS); covalent labeling MS; top-down MS; native MS

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Advances in the Structure and Function of Microtubule-Associated Motor Proteins

edited by Arne Gennerich

submission deadline 20 Nov 2025 | 1 articles | Viewed by 826 | Submission Open

Keywords: microtubules; kinesin; dynein; CryoEM; post-translational modifications

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Notch and Its Regulation in Health and Disease

edited by

Martin Baron

submission deadline 20 Nov 2025 | Viewed by 44 | Submission Open

Keywords: Notch; signalling; development; diseases

(This special issue belongs to the Section Molecular Medicine)

New Insights into Integrins

edited by

Yoshikazu Takada

submission deadline 30 Nov 2025 | 6 articles | Viewed by 12245 | Submission Open

Keywords: integrins; growth factors; ligands

(This special issue belongs to the Section Biological Factors)

Experimental and Theoretical Approaches to Protein-Targeting Drug Discovery: 2nd Edition

edited by

Caterina Vicidomini

and

Giovanni N. Roviello

submission deadline 30 Nov 2025 | 5 articles | Viewed by 10436 | Submission Open

Keywords: proteins; peptides; amyloid; aptamers; molecular docking; Alzheimer disease; Parkinson’ s disease; neurodrugs; biotechnological enzymes; antiviral drugs; vaccines; biomolecular targets; COVID-19; SARS-CoV-2; spike protein; peptide aggregation; drug repurposing; natural products; synthetic antivirals; anticancer therapeutics

(This special issue belongs to the Section Chemical Biology)

Design and Synthesis of Bioactive Compounds for Therapeutic Applications

edited by

Gerald Guillaumet

and

Saïd El Kazzouli

submission deadline 30 Nov 2025 | 8 articles | Viewed by 9245 | Submission Open

Keywords: drug design and discovery; synthesis of bioactive molecules; biological evaluations and applications; diagnostics; drug delivery

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Advances in p53 Research

edited by

Gabriella D’Orazi

submission deadline 30 Nov 2025 | 3 articles | Viewed by 8581 | Submission Open

Keywords: p53; small molecules; tumor suppressor; apoptosis; tumor– host interaction; targeted therapies; tumor microenvironment (TME)

(This special issue belongs to the Section Molecular Biology)

Colorectal and Gastric Cancers: Molecular Mechanisms and Potential Biomarkers

edited by

Jan Bures

and

Nicholas J. W. Rattray

submission deadline 30 Nov 2025 | 5 articles | Viewed by 7250 | Submission Open

Keywords: colorectal cancer; gastric cancer; molecular mechanism; biomarkers signalling; molecules gastrointestinal; microbiome; artificial intelligence

(This special issue belongs to the Section Molecular Biomarkers)

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