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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Endocrine Regulation of Reproductive Tissues: From Molecular Mechanisms to Therapies

edited by

Waldemar Grzegorzewski

submission deadline 25 Feb 2026 | Viewed by 131 | Submission Open

Keywords: hormone signaling; reproductive physiology; steroid receptors; infertility; endocrine disruptors; epigenetic regulation; gonadal steroids; hormone-dependent cancers; therapeutic targeting; gametogenesis

(This special issue belongs to the Section Biological Factors)

Role of Oxidative Stress in Vascular Diseases

edited by

Vittoria Cammisotto

and

Valentina Castellani

submission deadline 26 Feb 2026 | Viewed by 186 | Submission Open

Keywords: oxidative stress; vascular disease; endothelial dysfunction; NADPH oxidase/NOX2; platelet activation; autophagy; gut microbiota; inflammation; reactive oxygen species (ROS); cardiovascular risk

Extracellular Vesicles as Natural Nanocarriers: Advances in Cancer, Tissue Regeneration and Skin Health

edited by

Salvatore Panza

submission deadline 26 Feb 2026 | Viewed by 157 | Submission Open

Keywords: extracellular vesicles; natural nanocarriers; drug delivery; cancer therapy; regenerative medicine; skin health; dermocosmetics; tumor microenvironment; bioactive cargo; targeted delivery

Molecular Advances in Wound Healing and Skin Regeneration

edited by

Hiroyuki Ijima

and Muhammad Shafiq

submission deadline 28 Feb 2026 | 2 articles | Viewed by 29272 | Submission Open

Keywords: artificial dressings; electrospun fiber-based wound dressings; artificial skin equivalents; wound healing; instructive biomaterials for in situ skin repair; microneedles for skin therapy; drug delivery systems for wound healing; cell-free approaches for skin repair; stem cell therapy for wound healing; scarless skin repair

(This special issue belongs to the Section Biological Factors)

Design and Synthesis of Bioactive Compounds for Therapeutic Applications

edited by

Gerald Guillaumet

and

Saïd El Kazzouli

submission deadline 28 Feb 2026 | 11 articles | Viewed by 27121 | Submission Open

Keywords: drug design and discovery; synthesis of bioactive molecules; biological evaluations and applications; diagnostics; drug delivery

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Chronic Heart Failure: From Molecular Mechanisms to Therapies Strategies

edited by

Josep Comín-Colet

and

Marta Tajes

submission deadline 28 Feb 2026 | 9 articles | Viewed by 17733 | Submission Open

Keywords: chronic heart failure; pathophysiology; comorbidities; new therapies; molecular pathways

(This special issue belongs to the Section Molecular Medicine)

Cannabinoids in Neurobehavioral Modulation

edited by

Francisco Navarrete

and

María S. García Gutiérrez

submission deadline 28 Feb 2026 | 4 articles | Viewed by 17194 | Submission Open

Keywords: cannabinoids; neurobehavior; brain diseases; therapeutic; translational

(This special issue belongs to the Section Molecular Biology)

Inflammatory Mechanisms and Molecular Targets in Neurological Disorders: Effects of Neuroprotective Drugs

edited by

Jose Joaquin Merino

submission deadline 28 Feb 2026 | 4 articles | Viewed by 12433 | Submission Open

Keywords: neuroinflammation; neurological disorders; molecular targets; therapeutic strategies; neuroimmunology

(This special issue belongs to the Section Molecular Medicine)

Cellular Quiescence and Dormancy

edited by

Jürg Bähler

submission deadline 28 Feb 2026 | 6 articles | Viewed by 11985 | Submission Open

Keywords: quiescent cells; dormant cells; biostasis; diapause; spores; dauer larva

(This special issue belongs to the Section Molecular Genetics)

Immune Responses in Type 1 Diabetes

edited by

Eddie A. James

and Sally C. Kent

submission deadline 28 Feb 2026 | 5 articles | Viewed by 11964 | Submission Open

Keywords: type 1 diabetes; insulitis; immune response

(This special issue belongs to the Section Molecular Biology)

Innovative Biomolecular Structure Analysis Techniques

edited by Tzanko I. Doukov

submission deadline 28 Feb 2026 | 6 articles | Viewed by 10761 | Submission Open

Keywords: macromolecular crystallography; room temperature crystallography; protein ensembles; NMR; MD simulations

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Novel Molecules for Cancer Treatment (3rd Edition)

edited by

Javier Martínez Useros

submission deadline 28 Feb 2026 | 5 articles | Viewed by 9397 | Submission Open

Keywords: cancer; small molecules; antibody-drug-conjugated; tyrosine kinase inhibitors; target therapy; monoclonal antibodies; immunotherapy; natural compounds

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular and Cellular Mechanisms in Anti-Thrombosis

edited by

Joen-Rong Sheu

and

Thanasekaran Jayakumar

submission deadline 28 Feb 2026 | 3 articles | Viewed by 7914 | Submission Open

Keywords: platelet activation and thrombosis; neuroprotection; antithrombotic mechanisms

(This special issue belongs to the Section Molecular Medicine)

Structural Biology of Protein

edited by

Nabanita Saikia

submission deadline 28 Feb 2026 | 3 articles | Viewed by 7641 | Submission Open

Keywords: structural characterization; protein structure– function paradigm; biophysical techniques; computational methods; conformational dynamics; drug discovery; protein– protein interactions

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Biomarkers and Molecular Basis of Psychiatry

edited by

Massimo Tusconi

submission deadline 28 Feb 2026 | 3 articles | Viewed by 7558 | Submission Open

Keywords: mental health; bipolar disorders; mood; anxiety; psychosis; schizophrenia; biomarkers

(This special issue belongs to the Section Biological Factors)

Molecular Signalling Pathways in Tumorigenesis and Tumor Suppression

edited by

Kiyoshi Ohtani

submission deadline 28 Feb 2026 | 3 articles | Viewed by 6642 | Submission Open

Keywords: E2F; RB; p53; cancer; tumor suppression

(This special issue belongs to the Section Biological Factors)

Genetic and Genomic Biomarkers in Cancer Diagnosis, Prognosis, and Treatment Prediction

edited by

Jianli Dong

submission deadline 28 Feb 2026 | 3 articles | Viewed by 6073 | Submission Open

Keywords: laboratory genetics and genomics; genetic and genomic biomarkers; diagnostic; prognostic; predictive; companion diagnosis; targeted therapy; nucleic acid

(This special issue belongs to the Section Molecular Biomarkers)

Advancing Molecular Regulation in Brain Injury Research: Mechanisms, Diagnosis, and Rehabilitation

edited by Guanglin Zhang and

Pavan Thapak

submission deadline 28 Feb 2026 | 4 articles | Viewed by 5940 | Submission Open

Keywords: brain injury; biomarkers; neurodegeneration; neuroplasticity; neuroimaging; microbial dysbiosis; gut– brain axis; cognitive rehabilitation

(This special issue belongs to the Section Molecular Biology)

New Insights into Forensic Molecular Genetics

edited by

Erin K. Hanson

submission deadline 28 Feb 2026 | 2 articles | Viewed by 5937 | Submission Open

Keywords: forensic; DNA; RNA; protein; mtDNA; epigenetics; microbiome

(This special issue belongs to the Section Molecular Genetics)

Heterocyclic Compounds as Novel Anti-Cancer Agents and Their Mechanisms of Action

edited by Chandra Mishra and

Dnyaneshwar N. Garad

submission deadline 28 Feb 2026 | 2 articles | Viewed by 4809 | Submission Open

Keywords: heterocyclic compounds; anticancer; synthetic; natural

(This special issue belongs to the Section Molecular Medicine)

Glutamate and Glutamate Receptors in Health and Diseases, Second Edition

edited by

Jolanta H. Kotlińska

and

Marta Marszalek-Grabska

submission deadline 28 Feb 2026 | 3 articles | Viewed by 4396 | Submission Open

Keywords: glutamate receptors; addiction; pain; learning and memory; anxiety; depression; autism; neurodegeneration

(This special issue belongs to the Section Molecular Biology)

Polyphosphate (PolyP) in Health and Disease

edited by

Félix A. Ruiz

submission deadline 28 Feb 2026 | 3 articles | Viewed by 3294 | Submission Open

Keywords: polyphosphate; polyP; biomarker and therapeutic target

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Biomarkers in Metabolic Diseases, 2nd Edition

edited by

Anna Tylki-Szymańska

and

Patryk Lipiński

submission deadline 28 Feb 2026 | 1 articles | Viewed by 3016 | Submission Open

Keywords: metabolic disorders; inborn errors of metabolism; surrogate biomarkers; biochemical markers; diagnostic markers; newborn screening; molecular analyses; metabolomics; disease progression; treatment efficacy

(This special issue belongs to the Section Molecular Biomarkers)

Cellular and Molecular Mechanisms of Endometriosis: 2nd Edition

edited by

Luciana Bordin

, Alessandra Andrisani and Chiara Sabbadin

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2955 | Submission Open

Keywords: endocrine disfunction in endometriosis; glycosylphosphatidylinositols (GPIs) and GPI-anchored proteins; oxidative stress markers (glutathione; carbonic anhydrase; etc.); endometriosis and deep endometriosis; endometriosis-related immune system

(This special issue belongs to the Section Molecular Biology)

Hyaluronic Acid and Proteoglycans: Basic and Biomedical Applications: 2nd Edition

edited by

Michele Scuruchi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2921 | Submission Open

Keywords: hyaluronic acid; proteoglycans; GAGs; extracellular matrix; hyaluronic acid and proteoglycans in disease; cancer; inflammation; angiogenesis; vascular homeostasis and damage; arthritis and arthrosis; glycobiology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Tumor Genomics and Liquid Biopsy in Cancer Biology

edited by

Milena Urbini

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2834 | Submission Open

Keywords: circulating tumor DNA (ctDNA); circulating tumor cells (CTCs); exosomes and extracellular vesicles; circulating free RNAs and microRNAs; tumor heterogeneity; mechanisms of metastasis; tumor clonal evolution; drug resistance; tumor microenvironment; multi-omics integration

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanism and Detection of SARS-CoV-2

edited by

Zaki A. Sherif

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2742 | Submission Open

Keywords: SARS-CoV-2 spike protein; ACE2 receptor; viral pathogenesis; host-viral protein interactions; molecular diagnostics; RNA virus replication; immune response; viral structural proteins; pathobiology; RT-PCR detection

(This special issue belongs to the Section Molecular Biology)

Single-Molecule Protein Electronics

edited by

Stuart Lindsay

and Bintian Zhang

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2423 | Submission Open

Keywords: protein electronics; molecular electronics; single-molecule conductance; protein detection; protein sensing; label-free detection; conductance gating in proteins; electron transport mechanisms in proteins; coherence and dephasing in proteins; role of water in protein conductance; extended electronic states in proteins; hopping conductance in proteins; long-range hopping in proteins; electrode– protein interfaces; charge injection barriers at protein– electrode interfaces; proteins as electronic devices; protein assemblies as electronic devices; DNA electronics; electron transport in DNA; DNA– electrode interfaces; charge injection at a DNA– electrode interface; barrier to charge injection at a DNA– electrode interface

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Biology of Age-Related Macular Degeneration: From Pathogenesis to Therapeutic Strategies

edited by

Serena Fragiotta

, Pier Luigi Grenga and Chiara Ciancimino

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2319 | Submission Open

Keywords: age-related macular degeneration; vascular endothelial growth factor (VEGF); inflammation; neurodegeneration; single-nucleotide polymorphisms (SNP)

(This special issue belongs to the Section Molecular Biology)

Advances in the Pathology of Prostate Cancer: 2nd Edition

edited by

Piwen Wang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1849 | Submission Open

Keywords: prostate cancer; molecular pathology; biomarker; chemoprevention; therapy

(This special issue belongs to the Section Chemical Biology)

Molecular and Cellular Mechanisms of Aortic Diseases

edited by Maria Giovanna Scioli

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1758 | Submission Open

Keywords: aortic aneurysms; acute aortic syndromes; aortic dissection; intramural haematoma; penetrating atherosclerotic ulcer; traumatic aortic injury; pseudoaneurysm; aortic rupture; atherosclerotic; inflammatory affections; Marfan syndrome; congenital abnormalities; aortic diseases

(This special issue belongs to the Section Molecular Biology)

Exploring Thermophilic Enzymes: From Structural Foundations to Functional Enhancement

edited by

Renjun Gao

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1548 | Submission Open

Keywords: thermostable enzymes; structural biology; protein engineering; functional enhancement; industrial applications; thermal stability mechanisms; biotechnology

(This special issue belongs to the Section Enzymology)

Cellular and Molecular Mechanisms in Cardiorenal Syndrome

edited by

Rosemary Wangensteen

, María Carmen Ruiz Fuentes and Maria José Espigares Huete

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1236 | Submission Open

Keywords: cardiorenal syndrome; renal failure; heart; kidney; heart failure

(This special issue belongs to the Section Molecular Biology)

The Planarian Model in Pharmacology, Toxicology, and Neuroscience

edited by Oné R. Pagán

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1103 | Submission Open

Keywords: planarians; pharmacology; toxicology; neuroscience; neurotransmission; regeneration

(This special issue belongs to the Section Molecular Biology)

Insights into Mitochondria in Psychiatric Disorders

edited by Ji Geng

submission deadline 28 Feb 2026 | 1 articles | Viewed by 995 | Submission Open

Keywords: mitochondria; depression; schizophrenia; autism; neurodevelopmental disorders

(This special issue belongs to the Section Cellular Biochemistry)

Oxidative Stress and Ferroptosis in Health and Disease

edited by Udayakumar Karunakaran and Suma Elumalai

submission deadline 28 Feb 2026 | 1 articles | Viewed by 990 | Submission Open

Keywords: reactive oxygen species; antioxidants; glutathione; iron; H2S signaling; diabetes; metabolic disease; mitochondrial biology; ferroptosis; cell death; inflammation; aging; neurodegenerative diseases

(This special issue belongs to the Section Chemical Biology)

Biomarkers and Therapeutic Approaches in Melanoma: New Omics-Strategies

edited by

Italia Falcone

Fabio Valenti

and

Stefano Giuliani

submission deadline 28 Feb 2026 | 1 articles | Viewed by 747 | Submission Open

Keywords: melanoma; biomarkers; omics; precision oncology; drug resistance

(This special issue belongs to the Section Molecular Biomarkers)

Molecular Mechanisms and Drug Research in Alzheimer’s Disease

edited by

Xudong Huang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 680 | Submission Open

Keywords: Alzheimer's disease; molecular mechanisms; drug discovery; Aβ amyloid; tau protein; neuroinflammation; oxidative stress; metal homeostasis; blood– brain barrier; dysbiosis

(This special issue belongs to the Section Molecular Medicine)

Functional Analysis of Genes Related to DNA Damage

edited by Ryan P. Barnes and Amy M. Whitaker

submission deadline 28 Feb 2026 | 1 articles | Viewed by 465 | Submission Open

Keywords: DNA damage; DNA repair; genome stability; DNA replication stress

(This special issue belongs to the Section Molecular Biology)

Novel Insights and Applications of Pluripotent Stem Cells

edited by

Huseyin Sumer

and Ben Rollo

submission deadline 28 Feb 2026 | 1 articles | Viewed by 426 | Submission Open

Keywords: pluripotent stem cells; pluripotency; differentiation; stem cell transplant; regenerative medicine; disease modeling; organoids; therapeutic screening; cell therapies; drug discovery

(This special issue belongs to the Section Cellular Biochemistry)

Exploring Novel Molecular Pathways and Emerging Treatments for Neuromuscular Disorders

edited by

Arturo Lopez-Castel

submission deadline 28 Feb 2026 | Viewed by 385 | Submission Open

Keywords: gene therapy; repurposing; therapeutic oligonucleotides; personalized medicine; biomarkers

(This special issue belongs to the Section Molecular Medicine)

Studies of Protein Dynamics, Interactions, and Concentration by Fluorescence Fluctuation Correlation Spectroscopy (FFCS)

edited by Jieqiong Lou and Elvis Pandžić

submission deadline 28 Feb 2026 | 1 articles | Viewed by 383 | Submission Open

Keywords: fluorescence fluctuation correlation spectroscopy (FFCS); fluorescence correlation spectroscopy (FCS); image correlation spectroscopy (ICS); pair correlation function (pCF) analysis; line-scan correlation; protein dynamics; molecular diffusion; molecular flow; confinement dynamics; protein– protein interactions; membrane organization; intracellular transport; molecular crowding; spatiotemporal fluctuations; concentration heterogeneity; live-cell imaging; single-molecule analysis; quantitative fluorescence microscopy; biophysics; super-resolution fluctuation analysis

Virus-Host Protein Interactions

edited by

Benoit Coulombe

submission deadline 28 Feb 2026 | Viewed by 289 | Submission Open

Keywords: protein– protein interactions; antiviral drug discovery; protein target inhibitors

Novel Drug Targets and RNA Epigenetics in Cancer Therapy

edited by Manjeet K. Rao

submission deadline 28 Feb 2026 | Viewed by 275 | Submission Open

Keywords: RNA modifications; cancer epigenetics; novel drug targets; RNA therapeutics; tumorigenesis

(This special issue belongs to the Section Molecular Biology)

Cellular Signaling and Cardiovascular Diseases: From NF-κB to Golgi Dynamics

edited by

Tong-You Wei

submission deadline 28 Feb 2026 | Viewed by 245 | Submission Open

Keywords: cardiovascular diseases; NF-κ B signaling; vascular cells; epigenetic regulation; vascular inflammation; intercellular crosstalk; Golgi dynamics

(This special issue belongs to the Section Cellular Biochemistry)

Exploring the Pathophysiology of Epilepsy: Metabolic Mechanisms and Therapeutic Potential

edited by

Halina Baran

and Christoph Baumgartner

submission deadline 28 Feb 2026 | Viewed by 192 | Submission Open

Keywords: epilepsy; metabolic regulation; signaling pathways; kynurenic acid; seizure detection; antiseizure drugs; innovative therapies

(This special issue belongs to the Section Molecular Medicine)

Unveiling Protein Functions, Dynamics and Interactions in Health and Disease Using Experimental and Theoretical Approaches, 2nd Edition

edited by Alice Romagnoli,

Stefano Motta

and

Jesmina Rexha

submission deadline 28 Feb 2026 | Viewed by 192 | Submission Open

Keywords: protein structure and dynamics; protein– protein interactions; point mutations; molecular biology; molecular modeling; molecular dynamics; biochemistry; bioinformatics; protein– ligand interaction; protein– nucleic acid interaction; protein conformational changes

(This special issue belongs to the Section Chemical Biology)

VDAC1 as a Hub Protein–Modulation of VDAC1-Mediated Prograde Cell Death, Metabolism, Inflammation and Immunity via Interacting Proteins, Metabolites and Small Molecules

edited by Jay H. Chung and

Vito De Pinto

submission deadline 28 Feb 2026 | Viewed by 171 | Submission Open

Keywords: apoptosis; binding sites; ferroptosis; inflammation; metabolism; mitochondria; oxidative strass; pyroptosis; small molecules; VDAC

(This special issue belongs to the Section Cellular Biochemistry)

The N-Methyl-D-Aspartate (NMDA) Receptor: From Pathophysiology to Clinical Significance

edited by

Motohiro Okada

submission deadline 28 Feb 2026 | Viewed by 165 | Submission Open

Keywords: L-glutamate; D-serine; ionotropic glutamate receptors; psychiatric disorders; neurodegeneration; synaptic plasticity; epilepsy; pathophysiology; signaling

Zebrafish: A Gateway to Understanding Human Disease

edited by

Gregory Kelly

and

Marc Ekker

submission deadline 28 Feb 2026 | Viewed by 154 | Submission Open

Keywords: zebrafish development; genetic pathways in zebrafish and humans; a better understanding of human disease conditions related to zebrafish

Displaying special issue 151-200 on page 4 of 11.

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