Insights into Mitochondria in Psychiatric Disorders
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 313
Special Issue Editor
Special Issue Information
Dear Colleagues,
The role of mitochondria in neurodegenerative diseases has been widely studied; however, it is still unclear in psychiatric disorders, such as depression, bipolar disorders, schizophrenia, autism, and neurodevelopmental disorders. Mitochondria, as the "ATP factories", are frequently involved in apoptosis, reactive oxygen species (ROS) production, calcium imbalance, and inflammation induced by leaked mitochondrial DNA (mtDNA), and they also function as protein degradation hubs. As a dynamic organelle, mitochondria interact closely with other organelles like the endoplasmic reticulum (ER), lysosomes, lipid droplet, autophagosome, and ribosomes, undergoing mitophagy, fission and fusion, and continuously trafficking within cells, particularly in long-distance transport along neuronal axons. Whether mitochondrial abnormalities are a cause or consequence of psychiatric disorders, and how they influence these disorders, warrants further exploration.
This Special Issue is designed to highlight the link between the mitochondria and psychiatric disorders. In this regard, we would like to invite the submission of review articles focused on the abovementioned topics or original research articles linking mitochondria and psychiatric disorders in clinical or fundamental research.
Dr. Ji Geng
Guest Editor
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Keywords
- mitochondria
- depression
- schizophrenia
- autism
- neurodevelopmental disorders
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