Biomarkers and Molecular Basis of Psychiatry

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".

Deadline for manuscript submissions: 25 June 2025 | Viewed by 788

Special Issue Editor

Special Issue Information

Dear Colleagues,

Biomarkers and molecular basis of psychiatry encompass various aspects of scientific advancement. A significant correlation exists between biological factors and the functional and cognitive impairments involved in the onset and progression of multiple mental disorders. These findings underscore the necessity for more sophisticated staging models, emphasizing the integration of molecular, genetic, and structural variables. Current models incorporate patients into classifications that reflect a space–time continuum, taking into account the anatomical and functional mapping of the brain as well as the pathology's progression. This approach describes premorbid stages, onset, and the clinical trajectory, including manic, depressive, and partial or complete remission phases.

This Special Issue aims to collect high-level articles that propose to ascertain the deeper mechanisms underlying the genesis and course of psychiatric disorders, their modifications on the basis of endogenous and exogenous, molecular, genetic, and epigenetic factors, and the therapeutic and molecular intervention strategies that may result.

Contributors are welcome to submit original research articles, comprehensive reviews, and other common article types to this Special Issue.

Dr. Massimo Tusconi
Guest Editor

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Keywords

  • mental health
  • bipolar disorders
  • mood
  • anxiety
  • psychosis
  • schizophrenia
  • biomarkers

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Published Papers (1 paper)

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Review

35 pages, 2422 KiB  
Review
Biogenic Amine Metabolism and Its Genetic Variations in Autism Spectrum Disorder: A Comprehensive Overview
by Claudio Tabolacci, Angela Caruso, Martina Micai, Giulia Galati, Carla Lintas, Maria Elena Pisanu and Maria Luisa Scattoni
Biomolecules 2025, 15(4), 539; https://doi.org/10.3390/biom15040539 - 7 Apr 2025
Viewed by 476
Abstract
Autism spectrum disorder (ASD) is a genetically heterogeneous syndrome characterized by repetitive, restricted, and stereotyped behaviors, along with persistent difficulties with social interaction and communication. Despite its increasing prevalence globally, the underlying pathogenic mechanisms of this complex neurodevelopmental disorder remain poorly understood. Therefore, [...] Read more.
Autism spectrum disorder (ASD) is a genetically heterogeneous syndrome characterized by repetitive, restricted, and stereotyped behaviors, along with persistent difficulties with social interaction and communication. Despite its increasing prevalence globally, the underlying pathogenic mechanisms of this complex neurodevelopmental disorder remain poorly understood. Therefore, the identification of reliable biomarkers could play a crucial role in enabling early screening and more precise classification of ASD subtypes, offering valuable insights into its physiopathology and aiding the customization of treatment or early interventions. Biogenic amines, including serotonin, histamine, dopamine, epinephrine, norepinephrine, and polyamines, are a class of organic compounds mainly produced by the decarboxylation of amino acids. A substantial portion of the genetic variation observed in ASD has been linked to genes that are either directly or indirectly involved in the metabolism of biogenic amines. Their potential involvement in ASD has become an area of growing interest due to their pleiotropic activities in the central nervous system, where they act as both neurotransmitters and neuromodulators or hormones. This review examines the role of biogenic amines in ASD, with a particular focus on genetic alterations in the enzymes responsible for their synthesis and degradation. Full article
(This article belongs to the Special Issue Biomarkers and Molecular Basis of Psychiatry)
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