Cellular and Molecular Mechanisms in Cardiorenal Syndrome
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 119
Special Issue Editors
Interests: kidney health and disease; aminopeptidases; biomarkers
Special Issues, Collections and Topics in MDPI journals
Interests: kidney; nephrology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiorenal syndrome consists of an acute or chronic dysfunction of both the heart and kidney due to interactions between these organs. These interactions that are common in healthy individuals in order to maintain homeostasis are impacted when normal function of any of these organs is altered. There is a wide number of pathologies that can lead to cardiorenal syndrome. These pathologies can be of renal or cardiac origin. Renin–angiotensin–aldosterone system activation, mitochondrial dysfunction, inflammation, fibrosis, oxidative stress and tissue remodelling are related to organ dysfunction in patients with cardiorenal syndrome. Therefore, different mechanisms that implicate several molecular systems can worsen the cardiorenal syndrome. In-depth knowledge of the molecular mechanisms that are involved in cardiorenal syndrome might help us to understand the pathophysiological basis of this syndrome. In the same way, knowledge of these molecular mechanisms is essential for the research of novel therapeutical approaches that can be useful in the management of these patients. The goal of this Special Issue is to publish experimental and pre-clinical research articles or scientific reviews that study cellular and molecular mechanisms involved in cardiorenal syndrome. Articles can also be focused on the study of pharmacological approaches or pre-clinical assays that improve the progression of this syndrome.
Prof. Dr. Rosemary Wangensteen
Dr. María Carmen Ruiz Fuentes
Dr. Maria José Espigares Huete
Guest Editors
Manuscript Submission Information
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Keywords
- cardiorenal syndrome
- renal failure
- heart
- kidney
- heart failure
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