Glutamate and Glutamate Receptors in Health and Diseases, Second Edition
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 1129
Special Issue Editors
Interests: pharmacology; central nervous system; addiction; pain; learning and memory; anxiety; depression; glutamate receptors
Special Issues, Collections and Topics in MDPI journals
Interests: pharmacology; central nervous system; memory; addiction; glutamate; metabotropic glutamate receptors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The history of glutamate as a neurotransmitter began with T. Hayashi in 1952 when he reported that glutamate injections into dog cerebral ventricles induced seizures. Since then, it has become clear that glutamate is a major excitatory neurotransmitter in the mammalian central nervous system (CNS) and is essential for proper neuronal development, synaptic plasticity, and learning and memory. It acts through the activation of glutamate receptors that are subdivided into the following two classes: ionotropic receptors, which act as ion channels (AMPA, NMDA, and kainate receptors), and metabotropic receptors (mGluRs), which belong to the GPCRs that modulate the cascades of intracellular second messengers. Disturbances in glutamatergic function have been implicated in the pathophysiology of several neuropsychiatric disorders, including schizophrenia, drug abuse and addiction, autism, and depression, as well as in neurodegenerative diseases that were until recently poorly understood.
This Special Issue aims to collect research papers and reviews that focus on the role of glutamate or its receptors in CNS diseases. The intent is to provide novel mechanistic insights into the function of glutamate and glutamate receptors and their translational value for human diseases. We hope that this research can identify new potential pharmacological targets for therapy.
Prof. Dr. Jolanta H. Kotlińska
Dr. Marta Marszalek-Grabska
Guest Editors
Manuscript Submission Information
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Keywords
- glutamate receptors
- addiction
- pain
- learning and memory
- anxiety
- depression
- autism
- neurodegeneration
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