Advancing Molecular Regulation in Brain Injury Research: Mechanisms, Diagnosis, and Rehabilitation

Dear Colleagues,

Brain injury is associated with long-term neurological infirmities and remains an unsolved health calamity affecting domestic, military, and sporting environments worldwide. Brain injury involves a multifaceted cascade of events triggered by primary and secondary pathogenesis. These events include metabolic depression, excitotoxicity, inflammation, oxidative stress, BBB leakage and others. In recent years, it has been discovered that brain injury also affects the peripheral organs’ physiology such as the liver, intestine and intestinal microbiota which further impede the recovery of injury. Despite the tremendous progress in research and evidence-based therapies, brain injury remains the leading cause of morbidity and mortality worldwide. Therefore, understanding molecular regulation among the different brain regions and the interactions between the CNS and peripheral organs is instrumental for the treatment of brain injury.

This Special Issue aims to explore the latest research findings in the pathophysiology of brain injury, biomarkers of diagnosis and prognosis, novel drug targets and translational approaches, as well as state-of-the-art reviews to drive advancements in molecular regulation of brain injury pathogenesis to facilitate the early diagnosis and clinical management of brain injury.

Research areas may include (but are not limited to) the following:

1. Understand the cellular and molecular pathological responses instrumental to brain injury.
2. Identify novel biomarkers and imaging techniques for diagnosis and prognosis to brain injury.
3. Discover therapeutic targets for the prevention and treatment of brain injury.
4. Develop strategies of rehabilitation for the recovery of patients.

Dr. Guanglin Zhang
Dr. Pavan Thapak
Guest Editors

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