Functional Analysis of Genes Related to DNA Damage
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 28 February 2026
Special Issue Editors
Interests: oxidative stress; cancer and aging; DNA damage; DNA replication and genome stability
Special Issue Information
Dear Colleagues,
Since the 1970s, it has been understood that unrepaired DNA damage can increase mutagenesis and chromosomal instability. Humans have at least five broad DNA repair pathways, in addition to DNA damage tolerance pathways, and the proteins in these pathways work together on genome maintenance. The importance of these pathways is evident from clinical observation, with their mutation resulting in diseases such as Xeroderma Pigmentosum, Lynch syndrome, Fanconi anemia, etc. Accumulating evidence over the past two decades also shows that these DNA repair proteins are involved in other nuclear transactions including cell cycle control, DNA replication, immune cell diversity, epigenetics, and genome stability.
This Special Issue is a collection of research articles and reviews that highlight recent advances in how the proteins that maintain genome integrity and function are regulated. In addition to their fundamental enzymology, we will also highlight how these factors are manipulated in the context of pathologies such as cancer, premature aging, and neurodegeneration.
Dr. Ryan P. Barnes
Dr. Amy M. Whitaker
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- DNA damage
- DNA repair
- genome stability
- DNA replication stress
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