Functional Analysis of Genes Related to DNA Damage
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 413
Special Issue Editors
Interests: oxidative stress; cancer and aging; DNA damage; DNA replication and genome stability
Special Issue Information
Dear Colleagues,
Since the 1970s, it has been understood that unrepaired DNA damage can increase mutagenesis and chromosomal instability. Humans have at least five broad DNA repair pathways, in addition to DNA damage tolerance pathways, and the proteins in these pathways work together on genome maintenance. The importance of these pathways is evident from clinical observation, with their mutation resulting in diseases such as Xeroderma Pigmentosum, Lynch syndrome, Fanconi anemia, etc. Accumulating evidence over the past two decades also shows that these DNA repair proteins are involved in other nuclear transactions including cell cycle control, DNA replication, immune cell diversity, epigenetics, and genome stability.
This Special Issue is a collection of research articles and reviews that highlight recent advances in how the proteins that maintain genome integrity and function are regulated. In addition to their fundamental enzymology, we will also highlight how these factors are manipulated in the context of pathologies such as cancer, premature aging, and neurodegeneration.
Dr. Ryan P. Barnes
Dr. Amy M. Whitaker
Guest Editors
Manuscript Submission Information
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Keywords
- DNA damage
- DNA repair
- genome stability
- DNA replication stress
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