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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Basis of Mast Cells Activation and Medical Implications

edited by

Grzegorz Porebski

and

Matija Rijavec

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2432 | Submission Open

Keywords: mast cells; allergy; immediate hypersensitivity; molecular mechanisms

(This special issue belongs to the Section Biological Factors)

Biomolecules in Myocarditis and Inflammatory Heart Disease

edited by

Amarylis Wanschel

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2123 | Submission Open

Keywords: cardiomyocyte; macrophage; cardiac remodeling; oxidative and nitrosative stress; neutrophils

(This special issue belongs to the Section Molecular Medicine)

State-of-the-Art Molecular Structure and Dynamics and Biophysics in Asia

edited by

Xuanyu Meng

and

Ruhong Zhou

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2094 | Submission Open

Keywords: molecular modeling; molecular dynamics simulation; protein– protein interaction; protein folding; bioinformatics; molecular docking; drug design; machine learning

(This special issue belongs to the Section Chemical Biology)

Vertebrate Comparative Genomics

edited by Ya-Xiong Tao and

Shan He

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1910 | Submission Open

Keywords: vertebrate; comparative genomics; physiology; biochemistry; pathophysiology; protein structure-function; gene

(This special issue belongs to the Section Molecular Genetics)

The Value of Natural Compounds as Therapeutic Agents: 3rd Edition

edited by

Maria Beatrice Morelli

submission deadline 31 Dec 2025 | 3 articles | Viewed by 1896 | Submission Open

Keywords: natural compound; acute and chronic conditions; cell proliferation; cell death; cell differentiation

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Feature Papers in Molecular Biology Section 2025

edited by

Claudia Tanja Mierke

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1832 | Submission Open

Keywords: mechanobiology; cellular processes including metabolism; proliferation and motility; molecular motors and forces; molecular and biophysical techniques; organelle and membrane transport; exo- and endosomal trafficking; cell and biophysical signal transduction; the biomolecular synthesis of proteins; protein folding and post-translational modification of proteins and macromolecular assemblies

(This special issue belongs to the Section Molecular Biology)

Ion Channels in Cardiovascular and Metabolic Diseases

edited by

Shang-Zhong Xu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1799 | Submission Open

Keywords: Na+ channel; Ca2+ channel; K+ channel; TRP channel; store-operated channel; Cl− channel; cation channel; ryanodine receptor; mechanosenstive channels; piezo channels; SGLT-1 transporters; membrane transporters

(This special issue belongs to the Section Biological Factors)

Molecular Basis and Oxidative Stress of Thyroid Diseases

edited by

Małgorzata Karbownik-Lewińska

and

Jan Stȩpniak

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1779 | Submission Open

Keywords: thyroid diseases; oxidative stress; reactive oxygen species (ROS); thyroid hormone synthesis; molecular mechanisms; genetic mutations; epigenetic modifications; autoimmune thyroid diseases; Hashimoto thyroiditis; Graves' disease

(This special issue belongs to the Section Biological Factors)

Biomolecules and Their Impact on Biology and Translational Applications: Celebrating the Pioneering Work of Prof. Ho Jeong Kwon: 2nd Edition

edited by

Eun-Woo Lee

and Jiho Yoo

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1615 | Submission Open

Keywords: biomolecules; cancer; angiogenesis; autophagy; GPCRs; translational applications; target identification; proximity-labeling; molecular docking; molecular probe; molecular pharmacology

(This special issue belongs to the Section Cellular Biochemistry)

T Cell Ca²⁺ Signal Dynamics: An Emerging Landscape for Therapeutic Strategies

edited by David W. Thomas and

Marc André Lécuyer

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1482 | Submission Open

Keywords: T cell signaling; Ca signaling; TCR-activated signals; ER Ca release; ER Ca stores; store-operated Ca influx; ER Ca store depletion signals

(This special issue belongs to the Section Cellular Biochemistry)

Sperm Nuclear BASIC Proteins: From Chromatin Remodeling to Drug Development and Innovative Clinical Applications

edited by

Marina Piscopo

and

Carmen Di Giovanni

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1460 | Submission Open

Keywords: sperm nuclear basic proteins (SNBPs); spermatogenesis; epigenetics; drug development; chromatin remodeling; biomarkers of fertility; translational reproductive medicine

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Profiling and Identification of Molecular Signatures Associated with Natural Products: 2nd Edition

edited by

Juei-Tang Cheng

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1440 | Submission Open

Keywords: natural product; molecular mechanisms; repurposed molecules; disease model; human health

Immune Response to Allergens

edited by

Brigita Gradauskiene

submission deadline 31 Dec 2025 | Viewed by 964 | Submission Open

Keywords: allergy; immune response; allergen; sensitization; molecular allergology; diagnostics; specific immunotherapy

(This special issue belongs to the Section Cellular Biochemistry)

Phytohormones 2024–2025

edited by Guzel Kudoyarova

submission deadline 31 Dec 2025 | Viewed by 945 | Submission Open

Keywords: plant hormones; auxins; cytokinins; gibberellins; abscisic acid; ethylene; salicylic acid; jasmonates

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Genetic Insights into Cardiomyopathy: From Mechanisms to Medicine

edited by Xiao Fan and Youngil Lee

submission deadline 31 Dec 2025 | 1 articles | Viewed by 758 | Submission Open

Keywords: cardiomyopathy; genetics; epigenetics; genomics; genotype– phenotype correlation; genetic penetrance; precision medicine; mitochondria; personalized treatment; gene therapy

(This special issue belongs to the Section Molecular Genetics)

The Role of Extracellular Vesicles (EVs) in Cell-to-Cell Communication

edited by

Yuqian Yan

submission deadline 31 Dec 2025 | Viewed by 439 | Submission Open

Keywords: extracellular vesicles (EVs); tumorigenesis; initiation; progression; metastasis

(This special issue belongs to the Section Cellular Biochemistry)

Immunofluorescent Techniques in Animal Stem Cell Research

edited by

Jaromír Vašíček

and Andrea Svoradová

submission deadline 31 Dec 2025 | Viewed by 380 | Submission Open

Keywords: animal stem cells; fluorescence/confocal microscopy; flow cytometry; fluorescence-activated cell sorting; fluorescent protein assay; stem cell markers; cell therapy; drug screening; exosomes; DNA analysis

(This special issue belongs to the Section Molecular Biology)

Recent Developments in Organometallic Syntheses for Biomedical Applications

edited by Bala Moku

submission deadline 31 Dec 2025 | Viewed by 380 | Submission Open

Keywords: advanced organometallic syntheses; biomedical applications; drug discovery; disease treatment; imaging; targeted therapy

(This special issue belongs to the Section Molecular Medicine)

Prion Biology and Disease: Molecular Mechanisms and Emerging Technologies

edited by Takashi Onodera and

Akikazu Sakudo

submission deadline 31 Dec 2025 | Viewed by 374 | Submission Open

Keywords: prions; PrPC; PrPSc; prion strain diversity; neurodegeneration; immunodetection methods; nonthermal gas plasma; protein misfolding cyclic amplification (PMCA); real-time quaking-induced conversion (RT-QuIC)

Harnessing the Immune System Against Solid Cancer: New Targets and Novel Therapeutic Approaches

edited by

Milica Perišić Nanut

submission deadline 31 Dec 2025 | Viewed by 373 | Submission Open

Keywords: immune response in cancer; molecular mechanisms of immunosuppression; cysteine proteases and their inhibitors

(This special issue belongs to the Section Molecular Biology)

Sjogren’s Syndrome: Recent Updates and Perspectives

edited by

Carlo Perricone

submission deadline 31 Dec 2025 | Viewed by 358 | Submission Open

Keywords: Sjogren’ s syndrome; autoimmune inflammatory disease; genetics; biomarkers; Toll-like receptors; inflammasome chemokines

Molecular and Cellular Mechanisms of Aortic Aneurysms

edited by Maria Giovanna Scioli

submission deadline 31 Dec 2025 | Viewed by 272 | Submission Open

Keywords: aorthopaties; thoracic and abdominal aneurysms; pathogenetic mechanisms; aortic wall degeneration; biomarkers; targeted therapies

(This special issue belongs to the Section Molecular Biology)

State-of-the-Art Perspectives on tRNA and tRNA Aminoacylation

edited by

Tamara Hendrickson

submission deadline 31 Dec 2025 | Viewed by 271 | Submission Open

Keywords: tRNA; tRNA Aminoacylation; translation; tRNA processing and modification

(This special issue belongs to the Section Molecular Genetics)

Ion Channels in Neurological and Psychological Disorders

edited by

Xiang-Ping Chu

submission deadline 31 Dec 2025 | Viewed by 249 | Submission Open

Keywords: ion channels; neurological disorders; psychological disorder; brain; therapeutic target

(This special issue belongs to the Section Molecular Biology)

Emerging Insights into the Role of Polyamines in Cellular Metabolism and Function

edited by

Cassandra E. Holbert

and

Tracy Murray Stewart

submission deadline 31 Dec 2025 | Viewed by 243 | Submission Open

Keywords: polyamine metabolism; putrescine; spermidine; spermine; polyamines in development; polyamines in health and disease; polyamines in cancer; polyamines in plant physiology

(This special issue belongs to the Section Cellular Biochemistry)

Proteogenomics in Cancer Research

edited by

Chen Huang

submission deadline 31 Dec 2025 | Viewed by 222 | Submission Open

Keywords: bioinformatics; cancer research; proteogenomics; drug resistance; functional genomics

Lung Cancer: From Molecular Basis to Therapy

edited by

Paolo Borghetti

submission deadline 31 Dec 2025 | Viewed by 205 | Submission Open

Keywords: biomarkers; prognostic factors; predictive factors; genetic mutations and oncogenes; tumor suppressor genes; immune checkpoints and PD-L1; proteomic; genomic; radiomic

(This special issue belongs to the Section Molecular Biology)

Antituberculous Drugs: Progress and Challenges

edited by

Ana Cristina Faria Ribeiro

and Ana Maria Telmo Dias Pereira Vicente Cabral

submission deadline 31 Dec 2025 | Viewed by 156 | Submission Open

Keywords: antituberculostatic drugs; carriers; bioavailability; delivery systems

(This special issue belongs to the Section Chemical Biology)

The Role of DNA Methylation, Histone Modifications and MicroRNA in Cancer

edited by

Joanna Szczepanek

submission deadline 31 Dec 2025 | Viewed by 155 | Submission Open

Keywords: epigenetic regulation; DNA methylation; histone modifications; microRNA; cancer progression; therapeutic resistance; tumor suppressor genes; oncogenic reprogramming; personalized cancer therapy; epigenetic therapy

(This special issue belongs to the Section Molecular Genetics)

Nutritional Intervention and Molecular Mechanism of Liver Cancer

edited by

Xian-Yang Qin

and Yohei Shirakami

submission deadline 31 Dec 2025 | Viewed by 139 | Submission Open

Keywords: liver cancer; nutrient signaling; inflammation and metabolism; cancer stem cells; precision nutrition

(This special issue belongs to the Section Molecular Medicine)

Embryo Implantation: New Molecular Insights in Endometrial Receptivity, Trophoblast Invasion and Signaling

edited by

Hans-Werner Denker

, Evdokia Dimitriadis and Lois A. Salamonsen

submission deadline 15 Jan 2026 | 8 articles | Viewed by 27234 | Submission Open

Keywords: embryo implantation; endometrial receptivity; trophoblast invasion; signaling

(This special issue belongs to the Section Molecular Reproduction)

Updates on Mitochondria and Cancer

edited by

Antonella Cormio

and

Clara Musicco

submission deadline 15 Jan 2026 | 1 articles | Viewed by 946 | Submission Open

Keywords: mitochondrial dysfunction in cancer; mitochondrial metabolomics; mitochondria and cancer therapy; mitochondria and cancer drug resistance; prognostic/predictive mitochondrial markers in cancer tissues and body fluids

(This special issue belongs to the Section Biological Factors)

Muscular Dystrophy: From Molecular Basis to Therapies: 2nd Edition

edited by

Francesca Sciandra

and

Kinga I. Gawlik

submission deadline 15 Jan 2026 | Viewed by 363 | Submission Open

Keywords: muscular dystrophies; muscle regeneration; extracellular matrix; satellite cells; therapeutic approaches; animal models; clinical trials

Molecular Pathology, Diagnostics and Therapeutics of Retinal Diseases: 2nd Edition

edited by

Antonio Ferreras

submission deadline 15 Jan 2026 | Viewed by 344 | Submission Open

Keywords: retina; macula; macular edema; inflammatory mediators; optical coherence tomography; retinal imaging; biochemical marker; biomarker; pharmacological targeting

Inflammation and Immunity in Lung Disease

edited by

Xuexian Yang

submission deadline 15 Jan 2026 | Viewed by 149 | Submission Open

Keywords: lung; infection; inflammation; host defense; cytokine release syndrome; genetic deficiency

(This special issue belongs to the Section Cellular Biochemistry)

Skeletal Muscle Homeostasis and Regeneration: 2nd Edition

edited by

Ernő Zádor

submission deadline 15 Jan 2026 | Viewed by 107 | Submission Open

Keywords: skeletal muscle; homeostasis; regeneration; satellite cells; fiber type

(This special issue belongs to the Section Molecular Medicine)

Lipid Signaling in Neuroinflammation and Neurodegeneration

edited by

Jason R. Gerstner

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2203 | Submission Open

Keywords: lipid signaling; neuroinflammation; neurodegeneration; sphingolipids; eicosanoids; phospholipids; endocannabinoids; lipid mediators; molecular mechanisms; brain health

Mitochondrial ROS in Health and Disease

edited by

Frank Krause

submission deadline 31 Jan 2026 | 8 articles | Viewed by 32371 | Submission Open

Keywords: aging; apoptosis; respiratory chain; redox signaling; paclitaxel

(This special issue belongs to the Section Chemical Biology)

Feature Papers in Cellular Biochemistry

edited by

Anna Rita Franco Migliaccio

submission deadline 31 Jan 2026 | 9 articles | Viewed by 28887 | Submission Open

Keywords: cell signalling; cell death; intracellular trafficking (protein; lipids; cytoskeleton; etc.); host– pathogen interactions; extracellular vesicle biology; intercellular communication; autophagy; cellular metabolism; inter-organelle communication; membrane transport; mitochondrial dynamics and function; cell polarity

(This special issue belongs to the Section Cellular Biochemistry)

Inositol Phosphates in Health and Disease, 2nd Edition

edited by

Ivana Vucenik

and

Abulkalam M. Shamsuddin

submission deadline 31 Jan 2026 | 8 articles | Viewed by 25736 | Submission Open

Keywords: inositol polyphosphates (IPs); IP6; inositol pyrophosphate (PP-Ips); signal transduction; energy metabolism; anticancer activity; PCOS; metabolic diseases; pathological calcification; neuropsychiatric disease

(This special issue belongs to the Section Molecular Medicine)

Mitochondrial Medicine: A Themed Issue in Honor of Prof. Dr. Carl A. Pinkert

edited by

Matthew McKenzie

submission deadline 31 Jan 2026 | 5 articles | Viewed by 25411 | Submission Open

Keywords: mitochondrial biology; mitochondrial disease; mitochondrial DNA; mitochondrial medicine; metabolism; therapeutics; oxidative phosphorylation; reactive oxygen species

(This special issue belongs to the Section Molecular Medicine)

Harnessing Protein Design and Engineering for Therapeutic Applications

edited by Julia Shifman and Norman Metanis

submission deadline 31 Jan 2026 | 6 articles | Viewed by 19991 | Submission Open

Keywords: therapeutic peptides and proteins; protein design and engineering; chemical protein synthesis; chemoselective protein modification; posttranslational protein modification

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

New Insights into Kidney Disease Development and Therapy Strategies

edited by

José I. López

and

Claudia Manini

submission deadline 31 Jan 2026 | 7 articles | Viewed by 19648 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

The Immune System and Allergies

edited by

Marco Casciaro

submission deadline 31 Jan 2026 | 4 articles | Viewed by 14396 | Submission Open

Keywords: immune system; allergy; inflammation; hypersensitivity; immunology

(This special issue belongs to the Section Cellular Biochemistry)

Cellular and Molecular Mechanisms in Cardiopathy and Therapeutic Strategies

edited by Ying-Hsi Lin and Shengjie Lu

submission deadline 31 Jan 2026 | 8 articles | Viewed by 12622 | Submission Open

Keywords: heart failure; cardiac remodelling; contractile dysfunction; bioenergetics; gene replacement or editing

(This special issue belongs to the Section Molecular Medicine)

Digestive Enzymes in Health and Disease

edited by Stefan G. Pierzynowski, Kateryna Pierzynowska,

Piotr Wychowański

and

Janine Donaldson

submission deadline 31 Jan 2026 | 6 articles | Viewed by 12050 | Submission Open

Keywords: digestive enzymes; gastrointestinal health; enzyme replacement therapy; gut microbiome; metabolic disorders; enzyme regulation; disease biomarkers; inflammatory diseases; nutrient absorption; therapeutic enzymes

(This special issue belongs to the Section Enzymology)

Advances in Metabolites Produced by Microbiota

edited by

Arancha Llama-Palacios

submission deadline 31 Jan 2026 | 3 articles | Viewed by 11236 | Submission Open

Keywords: microbiota; metabolites; short-chain fatty acids; amino acids; vitamins

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Mechanisms of Metabolic Regulation Used by G Protein-Coupled Receptors

edited by

Hongxia Ren

and Jason M. Conley

submission deadline 31 Jan 2026 | 4 articles | Viewed by 11022 | Submission Open

Keywords: diabetes; obesity; metabolism; GPCR; signaling

(This special issue belongs to the Section Molecular Biology)

Advanced Biomaterials for Healing Oral Tissues

edited by Miki Taketomi Saito and

Rafael R. Lima

submission deadline 31 Jan 2026 | 1 articles | Viewed by 8997 | Submission Open

Keywords: biocompatible materials; biopolymers; dental implants; materials testing; pharmaceutical preparations; regeneration; regenerative medicine; tissue scaffolds; wound healing

(This special issue belongs to the Section Bio-Engineered Materials)

The Illumination of Biophysical Mechanisms by Hydrogen Exchange: A Themed Issue in Honor of Professor S. Walter Englander

edited by

A. Joshua Wand

submission deadline 31 Jan 2026 | 4 articles | Viewed by 8735 | Submission Open

Keywords: hydrogen exchange chemistry; HX– NMR; HX-MS; protein folding; allostery; protein binding; protein thermodynamics; protein biophysics; protein function

(This special issue belongs to the Section Molecular Biology)

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