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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pluripotent Stem Cells: From Basic Research to Therapeutic Applications

edited by

Claudia Spits

and

Diana Al Delbany

submission deadline 31 May 2025 | Viewed by 257 | Submission Open

Keywords: pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells; organoids; differentiation; regenerative medicine; disease modeling; cell therapy; therapeutic applications

(This special issue belongs to the Section Molecular Biology)

Ion Channels in Cardiovascular and Metabolic Diseases

edited by

Shang-Zhong Xu

submission deadline 31 May 2025 | Viewed by 233 | Submission Open

Keywords: Na+ channel; Ca2+ channel; K+ channel; TRP channel; store-operated channel; Cl− channel; cation channel; ryanodine receptor; mechanosenstive channels; piezo channels; SGLT-1 transporters; membrane transporters

(This special issue belongs to the Section Biological Factors)

Advances in Molecular Therapy Targeting DNA Damage and Repair Systems

edited by

Joy Mitra

Anirban Chakraborty

and Anahita Mojiri

submission deadline 31 May 2025 | Viewed by 210 | Submission Open

Keywords: DNA repair; DNA repair inhibitors; homologous recombination; genome instability; inflammation; DNA damage; cell death; apoptosis

(This special issue belongs to the Section Biological Factors)

iPSC-Derived Model for Mitochondrial Diseases

edited by Kristina Xiao Liang

submission deadline 31 May 2025 | Viewed by 188 | Submission Open

Keywords: iPSC; mitochondrial disease; cellular remodeling; mitochondrial dysfunction; therapeutic screening

(This special issue belongs to the Section Molecular Biology)

Tissue-Specific Organelle Dynamics

edited by

Agnese De Mario

and

Marta Giacomello

submission deadline 1 Jun 2025 | Viewed by 214 | Submission Open

Keywords: organelles crosstalk; organelles contact sites; organelle dynamics

(This special issue belongs to the Section Cellular Biochemistry)

New Insights into Essential Genes and Functions

edited by

Marcella Vacca

and

Ilaria Granata

submission deadline 10 Jun 2025 | 4 articles | Viewed by 9151 | Submission Open

Keywords: gene regulation; omics data; essentiality; epigenetics; machine learning

(This special issue belongs to the Section Molecular Genetics)

Mechanisms and Kinetics of Interactions of Biomolecules at Interfaces: 2nd Edition

edited by

Monika Wasilewska

Aneta Michna

and

Maria Morga

submission deadline 15 Jun 2025 | 4 articles | Viewed by 11636 | Submission Open

Keywords: biomolecule adsorption; kinetics of biomolecule adsorption; mechanisms of biomolecule deposition; interactions of biomolecules; techniques for the detection of biomolecules at solid substrates; interactions of proteins with biomolecules/biopolymers; protein and biomolecule systems; protein and biomolecule complexes

(This special issue belongs to the Section Bio-Engineered Materials)

Antibiotic Resistance Mechanisms and Their Potential Solutions

edited by Sung-Pin Tseng,

Cheng Yen Kao

and

Tsung-Ying Yang

submission deadline 15 Jun 2025 | 4 articles | Viewed by 9770 | Submission Open

Keywords: antibiotic resistance; antimicrobial development; molecular mechanism; priority for antibiotics; newly therapeutic approach

(This special issue belongs to the Section Molecular Biology)

Role of Neuroactive Steroids in Health and Disease: 2nd Edition

edited by

Roberto Cosimo Melcangi

submission deadline 15 Jun 2025 | 5 articles | Viewed by 6701 | Submission Open

Keywords: neurosteroids; neurodegenerative disorders; psychiatric disorders; physiological effects

(This special issue belongs to the Section Molecular Biology)

New Insights into Cardiovascular Immunology

edited by Susanne Sattler, Pilar Martín and Stephen Malin

submission deadline 15 Jun 2025 | 1 articles | Viewed by 3681 | Submission Open

Keywords: inflammation; autoimmunity; atherosclerosis; myocarditis; heart failure

(This special issue belongs to the Section Molecular Medicine)

Molecular Advances in Rett Syndrome and Other Chromatin Related Disorders

edited by

Floriana Della Ragione

and Salvatore Fioriniello

submission deadline 15 Jun 2025 | 2 articles | Viewed by 2229 | Submission Open

Keywords: Rett syndrome and other chromatin disorders; epigenetic diseases; molecular alterations in Rett syndrome and other chromatin diseases; novel genes associated with chromatin disorders; MeCP2-mediated molecular mechanisms; roles of epigenetic modulators in chromatin-related diseases; preclinical studies for chromatin diseases; novel diagnostic; prognostic and therapeutic approaches for chromatin disorders

(This special issue belongs to the Section Molecular Medicine)

Epstein-Barr Virus Disease Mechanisms and Stress Responses: 2nd Edition

edited by

Marshall Vance Williams

submission deadline 15 Jun 2025 | Viewed by 409 | Submission Open

Keywords: Epstein– Barr virus (EBV); reactivation; immune modulation; stress; aging

(This special issue belongs to the Section Molecular Medicine)

Advances in Computational Biology of Intrinsically Disordered Proteins

edited by

Paul Harrison

submission deadline 15 Jun 2025 | Viewed by 168 | Submission Open

Keywords: intrinsic disorder; compositional bias; prions; protein annotation; protein simulation

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Bioinspired and Biomimicking Materials for Biomedical Applications: Second Edition

edited by

Bahman Anvari

submission deadline 20 Jun 2025 | Viewed by 386 | Submission Open

Keywords: biomedical and biological imaging; biophotonics; biosensors; cell-based therapy; delivery systems; theranostics

Alterations in D-Amino Acid Metabolism in Psychiatric and Neurological Disorders: 2nd Edition

edited by

Alessandro Usiello

and

Francesco Errico

submission deadline 20 Jun 2025 | Viewed by 141 | Submission Open

Keywords: neurological disorders; psychiatric disorders; NMDA receptors; D-aspartate; D-serine

(This special issue belongs to the Section Molecular Biology)

Biomarkers and Molecular Basis of Psychiatry

edited by

Massimo Tusconi

submission deadline 25 Jun 2025 | 1 articles | Viewed by 1036 | Submission Open

Keywords: mental health; bipolar disorders; mood; anxiety; psychosis; schizophrenia; biomarkers

(This special issue belongs to the Section Biological Factors)

State-of-the-Art Perspectives on tRNA and tRNA Aminoacylation

edited by

Tamara Hendrickson

submission deadline 26 Jun 2025 | Viewed by 129 | Submission Open

Keywords: tRNA; tRNA Aminoacylation; translation; tRNA processing and modification

(This special issue belongs to the Section Molecular Genetics)

Early Adversity and the Immune Hypothesis: Call for a Dialogue between Basic and Clinical Neuroscience

edited by Arie Kaffman, Kate Ryan Kuhlman, Bridget L. Callaghan and Christine Heim

submission deadline 30 Jun 2025 | 10 articles | Viewed by 20924 | Submission Open

Keywords: early adversity; microglia; neuroinflammation; microbiome; psychopathology

(This special issue belongs to the Section Molecular Biology)

Advances in Protein-Ligand Interactions: From Structure, Function to Applications

edited by

Mateusz Banach

submission deadline 30 Jun 2025 | 7 articles | Viewed by 18583 | Submission Open

Keywords: bioinformatics; compound libraries; computational biology; de novo drug design; drug discovery; ligand binding; machine learning; molecular docking; molecular dynamics; protein complexes

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Inositol Phosphates in Health and Disease, 2nd Edition

edited by

Ivana Vucenik

and

Abulkalam M. Shamsuddin

submission deadline 30 Jun 2025 | 6 articles | Viewed by 12750 | Submission Open

Keywords: inositol polyphosphates (IPs); IP6; inositol pyrophosphate (PP-Ips); signal transduction; energy metabolism; anticancer activity; PCOS; metabolic diseases; pathological calcification; neuropsychiatric disease

(This special issue belongs to the Section Molecular Medicine)

Harnessing Protein Design and Engineering for Therapeutic Applications

edited by Julia Shifman and Norman Metanis

submission deadline 30 Jun 2025 | 5 articles | Viewed by 10367 | Submission Open

Keywords: therapeutic peptides and proteins; protein design and engineering; chemical protein synthesis; chemoselective protein modification; posttranslational protein modification

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Mitochondrial Medicine: A Themed Issue in Honor of Prof. Dr. Carl A. Pinkert

edited by

Matthew McKenzie

submission deadline 30 Jun 2025 | 5 articles | Viewed by 9894 | Submission Open

Keywords: mitochondrial biology; mitochondrial disease; mitochondrial DNA; mitochondrial medicine; metabolism; therapeutics; oxidative phosphorylation; reactive oxygen species

(This special issue belongs to the Section Molecular Medicine)

Cutting-Edge Research on the Analysis of Small Biomolecules in Foods, Plants, and Biological Samples, 2nd Edition

edited by

Maroula Kokotou

Petros Tarantilis

and

Christos Pappas

submission deadline 30 Jun 2025 | 5 articles | Viewed by 7352 | Submission Open

Keywords: bioactive food ingredients (primary and secondary metabolites); secondary metabolites— natural products liquid chromatography-mass spectrometry; Fourier transform infrared (FTIR) and Raman spectroscopic analysis; gas chromatography-mass spectrometry; high-resolution mass spectrometry; lipids— amino acids— carbohydrates; polyphenols– terpenes

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Neuroimmune Interactions in Neuropsychiatric Diseases

edited by

Luciana Frick

submission deadline 30 Jun 2025 | 3 articles | Viewed by 7008 | Submission Open

Keywords: neurology; psychiatry; immunity; glia

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Metabolic Regulation Used by G Protein-Coupled Receptors

edited by

Hongxia Ren

and Jason M. Conley

submission deadline 30 Jun 2025 | 3 articles | Viewed by 6398 | Submission Open

Keywords: diabetes; obesity; metabolism; GPCR; signaling

(This special issue belongs to the Section Molecular Biology)

Mitochondrial Proteins: From Import and Biogenesis to Complex Functional Network

edited by

Venkatesh Sundararajan

submission deadline 30 Jun 2025 | 1 articles | Viewed by 6168 | Submission Open

Keywords: mitochondrial proteins; import; biogenesis; metabolism; functional network; oxidative stress; small molecules; mitochondrial protein quality control; mitophagy

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

The Immune System and Allergies

edited by

Marco Casciaro

submission deadline 30 Jun 2025 | 3 articles | Viewed by 6100 | Submission Open

Keywords: immune system; allergy; inflammation; hypersensitivity; immunology

(This special issue belongs to the Section Cellular Biochemistry)

The Illumination of Biophysical Mechanisms by Hydrogen Exchange: A Themed Issue in Honor of Professor S. Walter Englander

edited by

A. Joshua Wand

submission deadline 30 Jun 2025 | 3 articles | Viewed by 5519 | Submission Open

Keywords: hydrogen exchange chemistry; HX– NMR; HX-MS; protein folding; allostery; protein binding; protein thermodynamics; protein biophysics; protein function

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Cardiovascular Remodeling

edited by

Mingyi Wang

submission deadline 30 Jun 2025 | 2 articles | Viewed by 5452 | Submission Open

Keywords: vascular remodeling aging; extracellular matrix; atherosclerosis peripheral; artery disease; chronic heart failure; cardiovascular associated cognitive decline

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Wound Healing and Skin Regeneration

edited by

Hiroyuki Ijima

and Muhammad Shafiq

submission deadline 30 Jun 2025 | 2 articles | Viewed by 5412 | Submission Open

Keywords: artificial dressings; electrospun fiber-based wound dressings; artificial skin equivalents; wound healing; instructive biomaterials for in situ skin repair; microneedles for skin therapy; drug delivery systems for wound healing; cell-free approaches for skin repair; stem cell therapy for wound healing; scarless skin repair

(This special issue belongs to the Section Biological Factors)

Human Reproductive Biology: Uncertainties and Controversies

edited by

Giuseppe Benagiano

Marwan Habiba

and Paola Bianchi

submission deadline 30 Jun 2025 | 2 articles | Viewed by 5094 | Submission Open

Keywords: molecular reproduction; endometriosis; endometrium; implantation; decidualization; placenta; cellular senescence; prostaglandin; inflammation; pregnancy; reproduction; implantation; decidualization; endometriosis; assisted reproductive technology; molecular reproductive biology; reproductive biology; reproductive immunology; reproductive medicine; reproductive endocrinology; molecular regulation of reproductive processes; embryo development; reproductive biology; gametogenesis and fertilization

(This special issue belongs to the Section Molecular Reproduction)

Advances in Liver X Receptors

edited by Kaori Endo-Umeda and

Makoto Makishima

submission deadline 30 Jun 2025 | 3 articles | Viewed by 4897 | Submission Open

Keywords: liver X receptor; lipid metabolism; cholesterol; oxysterol; atherosclerosis; non-alcoholic steatohepatitis; inflammation; tumor immunity

(This special issue belongs to the Section Molecular Biology)

Feature Papers in Cellular Biochemistry

edited by

Anna Rita Franco Migliaccio

submission deadline 30 Jun 2025 | 4 articles | Viewed by 4283 | Submission Open

Keywords: cell signalling; cell death; intracellular trafficking (protein; lipids; cytoskeleton; etc.); host– pathogen interactions; extracellular vesicle biology; intercellular communication; autophagy; cellular metabolism; inter-organelle communication; membrane transport; mitochondrial dynamics and function; cell polarity

(This special issue belongs to the Section Cellular Biochemistry)

Neurodevelopmental Disorders: Genetic Studies and Therapeutic Strategies

edited by

Susanna Pietropaolo

and Bruno Bontempi

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3536 | Submission Open

Keywords: mouse models; Autism Spectrum disorder; transgenic rodents; pharmacological treatments; gene-environment interactions; neurodevelopmental disorders; rare diseases

(This special issue belongs to the Section Molecular Genetics)

Molecular Basis of Stress- and Trauma-Related Disorders

edited by Vanessa Nieratschker

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3311 | Submission Open

Keywords: stress; trauma; epigenetics; genetics; molecular mechanisms; transgenerational transmission; neuronal adaptations; transcriptomics; proteomics; metabolomics

(This special issue belongs to the Section Molecular Medicine)

Chemical Biology and Biotechnology of Nucleosides, Nucleotides, and Nucleic Acids

edited by

Xingguo Liang

and

Xinjing Tang

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3040 | Submission Open

Keywords: nucleosides; nucleotides; nanostructure; circular ssDNA; circular RNA; quadruplex; conjugate; lncRNA; DNAzyme; ribozyme

(This special issue belongs to the Section Chemical Biology)

The Next Generation of Proteomics for Precision Medicine: Second Edition

edited by

Towia Libermann

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3016 | Submission Open

Keywords: proteomics; biomarkers; next-generation protein sequencing; diagnostics; protein quantitative trait locus; systems biology; precision medicine

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Neuron–Astrocyte Interactions in Neurological Function and Disease

edited by Micaela Zonta and Alessandro Di Spiezio

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2875 | Submission Open

Keywords: astrocytes; neuron-astrocyte communication; brain function; neurological disease

Innovative Biomolecular Structure Analysis Techniques

edited by Tzanko I. Doukov

submission deadline 30 Jun 2025 | 3 articles | Viewed by 2757 | Submission Open

Keywords: macromolecular crystallography; room temperature crystallography; protein ensembles; NMR; MD simulations

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Retinal Diseases: Molecular Mechanisms and Therapies

edited by

Ana Raquel Santiago

and Raquel Boia

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2726 | Submission Open

Keywords: retinal diseases; molecular mechanisms; therapeutic strategies; vision impairment; gene therapy; retinal degeneration; neuroprotection; innovative treatments

(This special issue belongs to the Section Cellular Biochemistry)

The Role of Modulating Intracellular Signaling in Immune System

edited by

Jian Song

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2678 | Submission Open

Keywords: signaling pathway; inflammation; autoimmune disease; treatment

(This special issue belongs to the Section Molecular Biology)

Recent Advances in the Enzymatic Synthesis of Bioactive Compounds

edited by

Bartłomiej Zieniuk

submission deadline 30 Jun 2025 | 3 articles | Viewed by 2646 | Submission Open

Keywords: biocatalysis; biotransformation; enzyme-catalyzed reactions; whole-cell catalysis; green chemistry; enzymes; phenolic compounds; polyphenols; lipases; lipophilization; enzymatic synthesis; esterification; transesterification; green and sustainable chemistry approaches; lipid modification

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Cellular Signaling in Cancer

edited by

Avisek Majumder

, Shabana Bano and Kasturi Nayak

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2540 | Submission Open

Keywords: signaling pathways; cancer; anti-cancer

(This special issue belongs to the Section Cellular Biochemistry)

Ligamentum Flavum Fibrosis and Hypertrophy

edited by

Prashanta Silwal

and Peter G. Alexander

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2319 | Submission Open

Keywords: lumbar spinal stenosis; ligamentum flavum hypertophy; fibrosus; stem cells; cell signaling; immunoregulation; aging and senescence; magnetic resonance imaging

Immune Modulation and Atherosclerosis

edited by Xinjie Lu

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2062 | Submission Open

Keywords: atherosclerosis; cardiovascular disease; immune modulatory therapy; vaccinations

(This special issue belongs to the Section Molecular Medicine)

Barrier Formation and Homeostasis in the Vertebrate Brain

edited by

Ramani Ramchandran

Karthikeyan Thirugnanam

and

Ankan Gupta

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2010 | Submission Open

Keywords: brain endothelial cell; pericytes; choroid plexus; retina; lymphatic; blood; astrocytes; oligodendrocytes; brain ventricle; microglia

(This special issue belongs to the Section Cellular Biochemistry)

Biomarkers in Metabolic Diseases, 2nd Edition

edited by

Anna Tylki-Szymańska

and

Patryk Lipiński

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1961 | Submission Open

Keywords: metabolic disorders; inborn errors of metabolism; surrogate biomarkers; biochemical markers; diagnostic markers; newborn screening; molecular analyses; metabolomics; disease progression; treatment efficacy

(This special issue belongs to the Section Molecular Biomarkers)

Cellular and Molecular Biology of Neurodevelopment

edited by

David M. Feliciano

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1876 | Submission Open

Keywords: neural stem cells; neuroblasts; neurons; glia; microglia; molecular pathways; genes; mutations; pharmacology; toxicology; neurodevelopment; neurodevelopmental disorders

(This special issue belongs to the Section Molecular Biology)

New Insights into Protein Aggregation in Condensed and Amyloid States

edited by

Eva Žerovnik

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1757 | Submission Open

Keywords: proteinopathies; protein aggregation; physico-chemical and biological properties of amyloid fibrils and protein condensates; signal and light transduction; interaction with lipid membranes; aggregating protein interactomes; bioinformatics and machine learning; molecular dynamics

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

New Discoveries in the Field of Neuropharmacology

edited by

Beatrice Mihaela Radu

and Bogdan Amuzescu

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1677 | Submission Open

Keywords: neurologic and psychiatric diseases pharmacology; in silico drug screening; in vitro pharmacology assays; animal models; neuropharmacogenomics; drug safety; blood brain barrier; electrophysiology; patch-clamp

(This special issue belongs to the Section Molecular Medicine)

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