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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Embryo Implantation: New Molecular Insights in Endometrial Receptivity, Trophoblast Invasion and Signaling

edited by

Hans-Werner Denker

, Evdokia Dimitriadis and Lois A. Salamonsen

submission deadline 15 Jul 2025 | 4 articles | Viewed by 6454 | Submission Open

Keywords: embryo implantation; endometrial receptivity; trophoblast invasion; signaling

(This special issue belongs to the Section Molecular Reproduction)

Muscular Dystrophy: From Molecular Basis to Therapies: 2nd Edition

edited by

Francesca Sciandra

and

Kinga I. Gawlik

submission deadline 15 Jul 2025 | Viewed by 181 | Submission Open

Keywords: muscular dystrophies; muscle regeneration; extracellular matrix; satellite cells; therapeutic approaches; animal models; clinical trials

Molecular Pathology, Diagnostics and Therapeutics of Retinal Diseases: 2nd Edition

edited by

Antonio Ferreras

submission deadline 15 Jul 2025 | Viewed by 176 | Submission Open

Keywords: retina; macula; macular edema; inflammatory mediators; optical coherence tomography; retinal imaging; biochemical marker; biomarker; pharmacological targeting

Molecular Mechanisms, Novel Diagnostics and Treatments of Gynecologic Cancer

edited by Panneerdoss Subbarayalu

submission deadline 15 Jul 2025 | Viewed by 128 | Submission Open

Keywords: biomarker; cancer biology; novel drug targets and therapeutics; cancer stem cells; tumorigenesis

(This special issue belongs to the Section Molecular Medicine)

Immune Responses in Type 1 Diabetes

edited by

Eddie A. James

and Sally C. Kent

submission deadline 20 Jul 2025 | 4 articles | Viewed by 4608 | Submission Open

Keywords: type 1 diabetes; insulitis; immune response

(This special issue belongs to the Section Molecular Biology)

Mitochondria as a Target for Tissue Repair and Regeneration

edited by

Igor A. Prudovsky

submission deadline 21 Jul 2025 | Viewed by 314 | Submission Open

Keywords: mitochondria; trauma; tissue repair; regeneration; inflammation; mitochondrial DAMPs; mitochondrial biogenesis; mitophagy

(This special issue belongs to the Section Molecular Biology)

Gametogenesis and Gamete Interaction, 2nd Edition

edited by

Hitoshi Sawada

submission deadline 25 Jul 2025 | 3 articles | Viewed by 3982 | Submission Open

Keywords: gametogenesis and meiosis; sperm attraction and activation; gamete interaction and recognition; species specificity and self/nonself-recognition in hermaphrodites; acrosome reaction sperm penetration of egg coat; gamete membrane fusion; polyspermy block; egg activation

(This special issue belongs to the Section Molecular Reproduction)

Inflammatory Mechanisms and Molecular Targets in Neurological Disorders: Effects of Neuroprotective Drugs

edited by

Jose Joaquin Merino

submission deadline 30 Jul 2025 | 1 articles | Viewed by 547 | Submission Open

Keywords: neuroinflammation; neurological disorders; molecular targets; therapeutic strategies; neuroimmunology

(This special issue belongs to the Section Molecular Medicine)

Biogenic Amines, Their Receptors and Transporters in Health and Disease: Commemorative Issue in Honor of Professor Marc G. Caron (1946–2022)

edited by

Raul Gainetdinov

Bruno Giros

, Jean Martin Beaulieu and Stephen S.G. Ferguson

submission deadline 31 Jul 2025 | 16 articles | Viewed by 47792 | Submission Open

Keywords: dopamine; serotonin; norepinephrine; epinephrine; histamine; trace amines; beta-phenylethylamine; GPCR; TAAR

(This special issue belongs to the Section Biological Factors)

Recent Developments in Mesenchymal Stem Cells

edited by

Antonietta Rosa Silini

and

Enrico Ragni

submission deadline 31 Jul 2025 | 8 articles | Viewed by 19577 | Submission Open

Keywords: mesenchymal stromal cell; regenerative medicine; secretome

(This special issue belongs to the Section Cellular Biochemistry)

Recent Advances in Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases: 2nd Edition

edited by

Adriana Georgescu

submission deadline 31 Jul 2025 | 6 articles | Viewed by 14873 | Submission Open

Keywords: cardiovascular disease; dyslipidemia; diabetes; obesity; inflammation; oxidative stress; biomarkers; microRNA; extracellular vesicles; cardiopulmonary disease

(This special issue belongs to the Section Molecular Biology)

Mitochondrial ROS in Health and Disease

edited by

Frank Krause

submission deadline 31 Jul 2025 | 5 articles | Viewed by 14081 | Submission Open

Keywords: aging; apoptosis; respiratory chain; redox signaling; paclitaxel

(This special issue belongs to the Section Chemical Biology)

Therapeutic Potential of Natural Products in Metabolic Diseases

edited by

Atanas G. Atanasov

Ronan Lordan

and

Ren-You Gan

submission deadline 31 Jul 2025 | 4 articles | Viewed by 12800 | Submission Open

Keywords: natural products; metabolic disorders; diabetes mellitus; dietary constituents; phytotherapy; integrative medicine; obesity; dyslipidemia; non-alcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated steatohepatitis (MASH); nutraceuticals; supplements

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular, Cellular, and Blood Biomarkers in Diagnosis, Prognosis, Monitoring, and Treatment

edited by

Jordi Camps

, Isabel Fort Gallifa and Xavier Gabaldó Barrios

submission deadline 31 Jul 2025 | 7 articles | Viewed by 11084 | Submission Open

Keywords: biomarkers; infectious diseases; laboratory medicine; non-communicable diseases

(This special issue belongs to the Section Molecular Biology)

Computational Analysis and Conformational Modeling for Protein Structure and Interaction

edited by

Clement Agoni

and

Indrani Bera

submission deadline 31 Jul 2025 | 8 articles | Viewed by 9155 | Submission Open

Keywords: protein structure prediction; drug discovery targeting proteins; structural bioinformatics; molecular dynamics simulations; protein– protein interactions; protein– ligand binding; conformational dynamics; molecular docking studies

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Insights into the Mechanism of Antipsychotic Drugs

edited by Serdar Dursun and

Massimo Tusconi

submission deadline 31 Jul 2025 | 2 articles | Viewed by 7201 | Submission Open

Keywords: psychotropic medications; antipsychotic drugs; schizophrenia; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

Cannabinoids in Neurobehavioral Modulation

edited by

Francisco Navarrete

and

María S. García Gutiérrez

submission deadline 31 Jul 2025 | 3 articles | Viewed by 5984 | Submission Open

Keywords: cannabinoids; neurobehavior; brain diseases; therapeutic; translational

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Inflammatory Bowel Disease

edited by

Antonietta Gerarda Gravina

and

Raffaele Pellegrino

submission deadline 31 Jul 2025 | 2 articles | Viewed by 5279 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; biologics; quality of life; diagnostic markers; prognostic markers; drug monitoring; antibodies

(This special issue belongs to the Section Molecular Medicine)

Omics Data Integration: Focusing on Molecular Biomarkers for Cancers and Diseases

edited by Cinzia Franchin

submission deadline 31 Jul 2025 | 3 articles | Viewed by 4977 | Submission Open

Keywords: omics data analysis; omics data integration; biomarker discovery; bioinformatics; cancers

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Advances in Cardiometabolic Health

edited by

Pamela Senesi

and

Anna Ferrulli

submission deadline 31 Jul 2025 | 2 articles | Viewed by 4038 | Submission Open

Keywords: obesity; cardiovascular diseases; biomarkers; lifestyle interventions; personalized medicine

(This special issue belongs to the Section Cellular Biochemistry)

The Role of Scaffold Proteins in Human Diseases

edited by László Buday and

Virag Vas

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3834 | Submission Open

Keywords: scaffold proteins; cellular signalling; protein– protein interactions; protein domains; human diseases; drug targets; protein complex formation; pathogenic alterations

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Genetic and Genomic Biomarkers in Cancer Diagnosis, Prognosis, and Treatment Prediction

edited by

Jianli Dong

submission deadline 31 Jul 2025 | 3 articles | Viewed by 2075 | Submission Open

Keywords: laboratory genetics and genomics; genetic and genomic biomarkers; diagnostic; prognostic; predictive; companion diagnosis; targeted therapy; nucleic acid

(This special issue belongs to the Section Molecular Biomarkers)

Artificial Intelligence (AI) in Biomedicine: 2nd Edition

edited by

Le Nguyen Quoc Khanh

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1868 | Submission Open

Keywords: bioinformatics and biomedical informatics; biomedical image processing; cancer genomics; data analysis and big data; data mining and text mining; e-Health machine learning and deep learning; molecular biology and medicine; natural language processing; single-cell sequencing analysis

(This special issue belongs to the Section Molecular Medicine)

Advanced Biomaterials for Healing Oral Tissues

edited by Miki Taketomi Saito and

Rafael R. Lima

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1857 | Submission Open

Keywords: biocompatible materials; biopolymers; dental implants; materials testing; pharmaceutical preparations; regeneration; regenerative medicine; tissue scaffolds; wound healing

(This special issue belongs to the Section Bio-Engineered Materials)

Chronic Heart Failure: From Molecular Mechanisms to Therapies Strategies

edited by

Josep Comín-Colet

and

Marta Tajes

submission deadline 31 Jul 2025 | 2 articles | Viewed by 1560 | Submission Open

Keywords: chronic heart failure; pathophysiology; comorbidities; new therapies; molecular pathways

(This special issue belongs to the Section Molecular Medicine)

Advancing Molecular Regulation in Brain Injury Research: Mechanisms, Diagnosis, and Rehabilitation

edited by Guanglin Zhang and

Pavan Thapak

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1247 | Submission Open

Keywords: brain injury; biomarkers; neurodegeneration; neuroplasticity; neuroimaging; microbial dysbiosis; gut– brain axis; cognitive rehabilitation

(This special issue belongs to the Section Molecular Biology)

Single-Molecule Protein Electronics

edited by

Stuart Lindsay

and Bintian Zhang

submission deadline 31 Jul 2025 | 2 articles | Viewed by 1079 | Submission Open

Keywords: protein electronics; molecular electronics; single-molecule conductance; protein detection; protein sensing; label-free detection; conductance gating in proteins; electron transport mechanisms in proteins; coherence and dephasing in proteins; role of water in protein conductance; extended electronic states in proteins; hopping conductance in proteins; long-range hopping in proteins; electrode– protein interfaces; charge injection barriers at protein– electrode interfaces; proteins as electronic devices; protein assemblies as electronic devices; DNA electronics; electron transport in DNA; DNA– electrode interfaces; charge injection at a DNA– electrode interface; barrier to charge injection at a DNA– electrode interface

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Mechanisms and Novel Treatments of Stroke

edited by Saif Ahmad and Naseem Akhter

submission deadline 31 Jul 2025 | Viewed by 1036 | Submission Open

Keywords: ischemic stroke; molecular mechanisms; neuroinflammation; signaling pathways; therapeutic approaches

(This special issue belongs to the Section Molecular Biology)

Developmental Biology of the Kidney: From Molecular Mechanisms to Congenital Disorders

edited by

Katarina Vukojević

and Anita Racetin

submission deadline 31 Jul 2025 | 1 articles | Viewed by 519 | Submission Open

Keywords: kidney development; renal physiology; kidney disease; molecular mechanisms; cellular signaling; gene expression; biomarkers; renal pathophysiology; therapeutic targets

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanism and Detection of SARS-CoV-2

edited by

Zaki A. Sherif

submission deadline 31 Jul 2025 | 1 articles | Viewed by 461 | Submission Open

Keywords: SARS-CoV-2 spike protein; ACE2 receptor; viral pathogenesis; host-viral protein interactions; molecular diagnostics; RNA virus replication; immune response; viral structural proteins; pathobiology; RT-PCR detection

(This special issue belongs to the Section Molecular Biology)

Role of Glutathione Peroxidase in Health and Disease

edited by R Steve Esworthy

submission deadline 31 Jul 2025 | Viewed by 435 | Submission Open

Keywords: GPX1; GPX2; GPX3; GPX4; GPX5; GPX6; GPX7; GPX8; selenium; cancer; pathology

(This special issue belongs to the Section Molecular Medicine)

Molecular and Cellular Mechanisms of Megakaryocyte and Platelet Production

edited by Pedro J. Real and

Laura Gutiérrez

submission deadline 31 Jul 2025 | Viewed by 408 | Submission Open

Keywords: megakaryocytes; platelets; omics; platelet disorders; inflammation

(This special issue belongs to the Section Cellular Biochemistry)

The Production and Destruction of Phytohormones by Microorganisms: Their Roles in the Promotion of Plant Growth and Resistance

edited by Guzel Kudoyarova

submission deadline 31 Jul 2025 | Viewed by 405 | Submission Open

Keywords: plant-growth-promoting bacteria (PGPB); mycorrhizae; auxins; cytokines; ethylene; abscisic acid; gibberellins; jasmonates; brassinolides; water relations; mineral nutrition; antioxidant system; protection against pathogens; salicylic acid; ethylene

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Obesity-Related Diseases in Children: Molecular Basis and Therapeutic Approaches

edited by

Dénes Molnár

and

Szilvia Bokor

submission deadline 31 Jul 2025 | Viewed by 325 | Submission Open

Keywords: childhood obesity; causes; therapy; epigenetics; biomolecules

(This special issue belongs to the Section Molecular Medicine)

Elucidating the Roles of Chromatin in Genomic Processes

edited by

Daniel M. Czajkowsky

and Meijun Liu

submission deadline 31 Jul 2025 | Viewed by 324 | Submission Open

Keywords: nucleosome positioning and occupancy; histone modifications; histone variants; nucleosome chaperones; nucleosome remodelers; insulator proteins; CTCF and cohesin; cis-regulatory elements; 3D genome structure; chromatin dynamics

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Recent Advances in Chromatin and Chromosome Molecular Research

edited by Xin Bi

submission deadline 31 Jul 2025 | Viewed by 316 | Submission Open

Keywords: chromatin; chromosome; genome; molecular mechanisms; regulation

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Advances in Liver Transplantation and Hepatocellular Carcinoma

edited by

Paolo De Simone

submission deadline 31 Jul 2025 | Viewed by 302 | Submission Open

Keywords: biomolecular markers of liver graft quality; the prediction role of biomolecular markers in liver transplantation; biomolecular markers of graft viability in the setting of machine perfusion technology; biomolecular markers of liver graft dysfunction; HCC biomarkers: AFP; PIVKA; and SPIK; the role of inflammation and immunity; standards of biomolecular HCC diagnosis; biomolecular-based diagnostic algorithms for HCC; biomolecular-based screening and prevention algorithms; advantages and pitfalls of existing biomolecular diagnosis

(This special issue belongs to the Section Molecular Biomarkers)

Exploring Novel Molecular Pathways and Emerging Treatments for Neuromuscular Disorders

edited by

Arturo Lopez-Castel

submission deadline 31 Jul 2025 | Viewed by 288 | Submission Open

Keywords: gene therapy; repurposing; therapeutic oligonucleotides; personalized medicine; biomarkers

(This special issue belongs to the Section Molecular Medicine)

Digestive Enzymes in Health and Disease

edited by Stefan G. Pierzynowski, Kateryna Pierzynowska,

Piotr Wychowański

and

Janine Donaldson

submission deadline 31 Jul 2025 | Viewed by 272 | Submission Open

Keywords: digestive enzymes; gastrointestinal health; enzyme replacement therapy; gut microbiome; metabolic disorders; enzyme regulation; disease biomarkers; inflammatory diseases; nutrient absorption; therapeutic enzymes

(This special issue belongs to the Section Enzymology)

Key Molecules Regulating Plant Response to Abiotic Stress: Transcription Factors and Stress-Induced Proteins

edited by

Fei Gao

submission deadline 31 Jul 2025 | Viewed by 254 | Submission Open

Keywords: abiotic stress response; transcription factors; stress-induced proteins; molecular mechanisms; transcriptomics; omics; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Mechanisms of Gene Regulation in Embryos

edited by

Jo Qian

and Adam Davis

submission deadline 31 Jul 2025 | Viewed by 236 | Submission Open

Keywords: embryonic development; gene regulation; epigenetics; transcriptional control; post-transcriptional control; translational control; post-translational modification; signaling pathways; developmental disorders

(This special issue belongs to the Section Molecular Biology)

Cellular and Molecular Mechanisms in Cardiopathy and Therapeutic Strategies

edited by Ying-Hsi Lin and Shengjie Lu

submission deadline 31 Jul 2025 | Viewed by 222 | Submission Open

Keywords: heart failure; cardiac remodelling; contractile dysfunction; bioenergetics; gene replacement or editing

(This special issue belongs to the Section Molecular Medicine)

Recent Developments in Organometallic Syntheses for Biomedical Applications

edited by Bala Krishna Moku

submission deadline 31 Jul 2025 | Viewed by 221 | Submission Open

Keywords: advanced organometallic syntheses; biomedical applications; drug discovery; disease treatment; imaging; targeted therapy

(This special issue belongs to the Section Molecular Medicine)

Reactive Oxygen Species (ROS) Signaling in Response to Environmental Stressors

edited by Haoran Yu and

Samuel Dudley

submission deadline 31 Jul 2025 | Viewed by 194 | Submission Open

Keywords: ROS signaling; oxidative stress; mitochondrial function; environmental stressors; cellular signaling pathways; inflammation; toxicity endpoint; cell viability; gene expression; cytokine production

(This special issue belongs to the Section Cellular Biochemistry)

Focus on Perineural Invasion in Pancreatic Cancer

edited by

Ingrid Garajová

submission deadline 31 Jul 2025 | Viewed by 193 | Submission Open

Keywords: pancreatic cancer; perineural invasion; pain; NGF; neutrophins

(This special issue belongs to the Section Molecular Medicine)

Molecular Biology of Age-Related Macular Degeneration: From Pathogenesis to Therapeutic Strategies

edited by

Serena Fragiotta

, Pier Luigi Grenga and Chiara Ciancimino

submission deadline 31 Jul 2025 | Viewed by 177 | Submission Open

Keywords: age-related macular degeneration; vascular endothelial growth factor (VEGF); inflammation; neurodegeneration; single-nucleotide polymorphisms (SNP)

(This special issue belongs to the Section Molecular Biology)

Genomics and Molecular Biology of Solid Tumors

edited by Dragoş Creţoiu and Silviu Cristian Voinea

submission deadline 31 Jul 2025 | Viewed by 155 | Submission Open

Keywords: solid tumors; tumor microenvironment; genomic instability; cancer stem cells; liquid biopsy

(This special issue belongs to the Section Molecular Biology)

Genomic Insights into Microbial Infections

edited by

Weihua Huang

submission deadline 31 Jul 2025 | Viewed by 149 | Submission Open

Keywords: emerging pathogens; microbial evolution; pathogen– host interactions; infection prevention and treatment

(This special issue belongs to the Section Bioinformatics and Systems Biology)