Lipid Signaling in Neuroinflammation and Neurodegeneration
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 20 January 2026 | Viewed by 146
Special Issue Editor
2. Steve Gleason Institute for Neuroscience, Washington State University, Spokane, WA 99202, USA
Interests: molecular mechanisms; sleep; circadian rhythms; lipid signaling; neuroinflammation; neurodegenerative disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue will explore the crucial role played by lipid signaling pathways in the mechanisms underlying neuroinflammation and neurodegenerative diseases. Lipids are essential biological molecules that serve not only as structural components of cell membranes but also as active signaling mediators influencing numerous neural processes. Alterations in lipid metabolism and signaling have been linked to various neurodegenerative conditions, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis (ALS). Understanding how lipid-derived mediators such as sphingolipids, phospholipids, eicosanoids, and endocannabinoids regulate neuroinflammatory responses will open up promising avenues for novel therapeutic strategies. This Special Issue will elucidate the molecular mechanisms through which lipid signaling modulates neural inflammation and cell survival and death, providing insights into potential lipid-based biomarkers and drug targets. Interdisciplinary research combining biochemistry, neurobiology, and molecular biology is central in advancing our knowledge of lipid functions in the diseased brain. By consolidating recent findings, this Special Issue will foster a comprehensive understanding of the influence of lipid signaling in neuroinflammation and neurodegeneration, ultimately contributing to the development of better diagnostic and therapeutic approaches.
Dr. Jason R. Gerstner
Guest Editor
Manuscript Submission Information
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Keywords
- lipid signaling
- neuroinflammation
- neurodegeneration
- sphingolipids
- eicosanoids
- phospholipids
- endocannabinoids
- lipid mediators
- molecular mechanisms
- brain health
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