Embryo Implantation: New Molecular Insights in Endometrial Receptivity, Trophoblast Invasion and Signaling

Dear Colleagues,

We are pleased to invite you to contribute to this Special Issue of Biomolecules. An impressive amount of molecular and cellular data has been accumulated in this field in recent years, making it timely to not only review these, but also achieve a better understanding of the biology of implantation. More than 30 years ago, a new approach was initiated in implantation research, transitioning from the previous dominance of endocrinology to asking cell biological questions, such as the EMT concept that was new at that time. With the advent of molecular approaches, omics technologies, sophisticated 3D in vitro models and more detailed insights into signaling processes, including those of extracellular vesicles, we believe it is time to provide a comprehensive overview, to ask what new insights can be obtained and what may be achieved in the coming decade.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following:

• The processes involved: epithelial transformation, decidual transformation, trophoblast differentiation, signaling (including extracellular vesicles), endometrial–embryo interactions, immune influence;
• Emerging technologies: endometrial organoids (assembloids) and 3D cultures, endometrial stem cells, embryo mimics/trophoblast organoids and blastoids, endometrial multi-omics key pathways, single-cell omics and interactomes, spatial omics of the endometrium and implantation site;
• Rethinking of established concepts: role of progesterone supplementation, recurrent implantation failure, ethics (using human organoids and embryoids in research), window of endometrial receptivity.

We look forward to receiving your contributions.

Prof. Dr. Hans-Werner Denker
Prof. Dr. Evdokia Dimitriadis
Prof. Dr. Lois A. Salamonsen
Guest Editors

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• embryo implantation
• endometrial receptivity
• trophoblast invasion
• signaling