Molecular Mechanisms of Metabolic Regulation Used by G Protein-Coupled Receptors
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 6300
Special Issue Editors
2. Stark Neurosciences Research Institute, Indianapolis, IN, USA
3. Department of Biochemistry & Molecular Biology; Department of Pharmacology & Toxicology; Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Interests: diabetes; obesity; metabolism; glucose metabolism; insulin; feeding; G protein-coupled receptor (GPCR); metabolic disease; signaling; cyclic AMP (cAMP); calcium; central nervous system (CNS); intestine; glucagon-like peptide-1 (GLP-1); glucose-stimulated insulin secretion (GSIS); enteroendocrine cell (EEC); inducible knockout
Interests: G protein-coupled receptor (GPCR); cyclic AMP (cAMP); gut peptide; diabetes; obesity; metabolism
Special Issue Information
Dear Colleagues,
We are pleased to announce a Special Issue on the molecular mechanisms of metabolic regulation used by G protein-coupled receptors. Metabolic diseases such as obesity and type 2 diabetes are global health challenges. The G protein-coupled receptors (GPCRs) are seven transmembrane-domain proteins that regulate metabolism within many tissues in the central nervous system, gastrointestinal tract, liver, adipose tissue, and pancreatic islets. GPCRs transduce physiological cues, including those from hormones, neurotransmitters, ions, metabolites, peptides, fatty acids, odorants, and photons, into cellular signaling cascades. Though GPCRs are emerging therapeutic targets for diabetes and obesity drug development, we do not yet fully understand their molecular regulation of signaling activities and physiological functions. This Special Issue of Biomolecules aims to gather a collection of original research articles and reviews pertaining to the most recent advances in our understanding of G protein-coupled receptors’ regulation of metabolism. The topics of successful submissions may include in vitro and/or in vivo investigations of the endocrine mechanisms behind metabolic regulation and pathophysiology.
We welcome both original research articles and reviews. Their research areas may include (but are not limited to) the following:
- The actions of GPCRs in metabolic organs (e.g., the central nervous system, gut, liver, fat, islets);
- GPCR signaling;
- GPCR-derived chemical probes for metabolic regulation;
- The pathophysiology of GPCRs in metabolic regulation;
- GPCR-based drug development for diabetes and obesity;
- The metabolic function of GPCR ligands;
- Receptor genetic variants associated with metabolic diseases;
- GPCR studies using knockout or other transgenic approaches;
- The interplay between intestinal GPCRs and the gut microbiome;
- GPCRs’ structure and function;
- GPCR chemical probe development using HTS or medicinal chemistry approaches.
We look forward to receiving your contributions.
Dr. Hongxia Ren
Dr. Jason M. Conley
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- diabetes
- obesity
- metabolism
- GPCR
- signaling
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