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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Computational Intelligence in Structure and Function Prediction and Modeling of Proteins—2nd Edition

edited by

Jian Zhang

Bi Zhao

and Haiting Chai

submission deadline 15 Jun 2026 | 4 articles | Viewed by 8370 | Submission Open

Keywords: protein tertiary structure; protein folding; protein functions; intrinsic disorder; drug discovery; protein– drug interaction; computational intelligent algorithms; artificial intelligence for proteomics; high-throughput proteomics

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Epigenetic Drivers of Cancer Metastasis: From Methylation to Non-Coding RNAs

edited by

Toshifumi Hara

submission deadline 19 Jun 2026 | 2 articles | Viewed by 1970 | Submission Open

Keywords: epigenetics; metastasis; DNA methylation; RNA methylation; non-coding RNAs

Cellular Stress Responses in Oncogenesis and Metabolic Reprogramming

edited by

Kuo Hui Su

submission deadline 19 Jun 2026 | Viewed by 152 | Submission Open

Keywords: cellular stress response; metabolic reprogramming; oncogenesis; lipid metabolism; tumor adaptation; mitochondrial metabolism

(This special issue belongs to the Section Cellular Biochemistry)

Advances in p53 Research

edited by

Gabriella D’Orazi

submission deadline 20 Jun 2026 | 3 articles | Viewed by 15895 | Submission Open

Keywords: p53; small molecules; tumor suppressor; apoptosis; tumor– host interaction; targeted therapies; tumor microenvironment (TME)

(This special issue belongs to the Section Molecular Biology)

Molecular Biomarkers of Epileptogenesis

edited by

Pedro J. Serrano-Castro

submission deadline 20 Jun 2026 | 4 articles | Viewed by 14347 | Submission Open

Keywords: epileptogenesis; neuroinflammation; biomarkers; drug-resistant epilepsy; personalized neurology

(This special issue belongs to the Section Molecular Biomarkers)

Biochemistry and Molecular Biology of Vitamin D and Its Analog, 3rd Edition

edited by

Toshiyuki Sakaki

and Naoko Tsugawa

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1529 | Submission Open

Keywords: vitamin D; vitamin D receptor; vitamin D analog; genomic action; non-genomic action; bone formation; immune response; cancer; rickets; osteoporosis; psoriasis; drug discovery; disease prevention; nutrition improvement metabolism of vitamin D or its analogs cytochrome P450

(This special issue belongs to the Section Chemical Biology)

The Structure and Function of MHC Class I Molecules in Health and Disease: Implications in Aging and Neuro-Immune Crosstalk

edited by

Elsa Maria Cardoso

and

Fernando Arosa

submission deadline 20 Jun 2026 | Viewed by 110 | Submission Open

Keywords: classical MHC-I molecules; human leukocyte antigen (HLA) class I; soluble HLA class I; immunological and non-immunological functions; neuro-immune crosstalk; aging and brain cognition

(This special issue belongs to the Section Cellular Biochemistry)

South American Native Species as Sources of Bioactive Compounds: Opportunities and Challenges

edited by Andressa Mara Baseggio and Maurício Ariel Rostagno

submission deadline 20 Jun 2026 | Viewed by 96 | Submission Open

Keywords: South American biodiversity; bioactive compounds; chemical characterization; health properties

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Oral Cancer: New Advances in Therapies

edited by

Daniela Adamo

Gennaro Musella

and Nicola Cirillo

submission deadline 20 Jun 2026 | Viewed by 95 | Submission Open

Keywords: oral cancer; targeted therapy; immunotherapy; biomarkers; tumor microenvironment; radiotherapy; chemotherapy; gene therapy; precision medicine; translational research

(This special issue belongs to the Section Molecular Medicine)

Advances in Cellular and Molecular Mechanisms in Immuno-Oncology and Onco-Hematology: 2nd Edition

edited by

Paolo Fagone

submission deadline 20 Jun 2026 | Viewed by 93 | Submission Open

Keywords: cancer immunotherapy; inhibitory immune checkpoints; CAR T cells; tumor immune evasion; cancer target therapy

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Mechanisms and Therapeutic Potential of Extracellular Vesicles in Neurovascular Diseases

edited by

Ji Chen Bihl

submission deadline 20 Jun 2026 | Viewed by 85 | Submission Open

Keywords: extracellular vesicles; neurovascular diseases; cellular communications; biomarkers; therapeutic targets

(This special issue belongs to the Section Cellular Biochemistry)

Novel Signaling Pathways in Cardiometabolic Diseases

edited by

Wei Liu

submission deadline 20 Jun 2026 | Viewed by 64 | Submission Open

Keywords: metabolic disorder; hypertension; stroke; cardiovascular disease; molecular mechanisms; hypertrophy; fibrosis; lipotoxiocity; mitochondrial function; inflammation

(This special issue belongs to the Section Biological Factors)

WDFY1 in Immune Regulation and Disease: From Molecular Mechanisms to Therapeutic Applications

edited by Wenhai Shao

submission deadline 20 Jun 2026 | Viewed by 61 | Submission Open

Keywords: WDFY1; membrane tracking; TLR3; TLR4; autophagy; ubiquitination; lupus

(This special issue belongs to the Section Molecular Medicine)

The Role of Nanoparticles in Tumor Treatment

edited by

Carla Vitorino

submission deadline 25 Jun 2026 | 3 articles | Viewed by 11607 | Submission Open

Keywords: nanoparticles; cancer therapy; nanotechnology

(This special issue belongs to the Section Chemical Biology)

Pulmonary Fibrosis: From Molecular Mechanism to Therapeutic Targets

edited by Santosh Yadav, Muralidharan Anbalagan and Renat Shaykhiev

submission deadline 25 Jun 2026 | Viewed by 109 | Submission Open

Keywords: idiopathic pulmonary fibrosis; DNA damage response; senescence; immune checkpoint inhibitors

(This special issue belongs to the Section Molecular Medicine)

Intercellular Communication in Differentiation

edited by

Alvin Liu

submission deadline 25 Jun 2026 | Viewed by 39 | Submission Open

Keywords: intercellular communication; cellular differentiation; transcription factors; signaling hormone molecules

Plant Molecular Stress Physiology—Elucidation of Plant Responses and Defense Mechanisms Against Stress

edited by

Hakim Manghwar

submission deadline 26 Jun 2026 | 2 articles | Viewed by 1391 | Submission Open

Keywords: plant stress responses; biotic and abiotic stresses; molecular mechanisms of plant stress; plant defense mechanisms; stress tolerance in plants; signaling pathways in plant stress; gene-expression changes under stress; genomic tools for plant stress research; biotechnological approaches for stress-tolerant plants; adaptation strategies of plants to stress; physiological changes in plants under stress; crop resilience to stress; horticultural plant stress physiology; stress-related signaling molecules in plants; practical agricultural applications of stress research

(This special issue belongs to the Section Molecular Biology)

Molecular Genetics and Molecular Breeding in Plants: Advances, Applications, and Future Directions

edited by Yurong Xie and Hongbin Wei

submission deadline 26 Jun 2026 | 2 articles | Viewed by 1156 | Submission Open

Keywords: molecular genetics; molecular breeding; genome editing (CRISPR); omics technologies; stress resilience; trait discovery; genomic selection; sustainable agriculture; crop improvement; artificial intelligence in breeding

(This special issue belongs to the Section Molecular Genetics)

Design, Synthesis, and Therapeutic Applications of Heterocycles for Major and Neglected Diseases

edited by

Balraj Gopula

Tamal Kanti Das

and Arun Raja

submission deadline 26 Jun 2026 | Viewed by 209 | Submission Open

Keywords: heterocyclic compounds; medicinal chemistry; drug design; synthetic methodology; structure– activity relationship (SAR); major diseases; neglected tropical diseases; pharmacology

(This special issue belongs to the Section Chemical Biology)

Spotlight on Hot Cancer Biological Biomarkers

edited by

Dania Cioni

and

Salvatore Claudio Fanni

submission deadline 30 Jun 2026 | 4 articles | Viewed by 9732 | Submission Open

Keywords: cancer biomarkers; precision medicine; liquid biopsy; imaging biomarkers; translational oncology

(This special issue belongs to the Section Molecular Biomarkers)

Mechanisms of Kidney Injury and Treatment Modalities

edited by Utpal Sen

submission deadline 30 Jun 2026 | 2 articles | Viewed by 8073 | Submission Open

Keywords: acute and chronic kidney injury; autophagy and mitophagy; bioenergetics; mitochondrial damage; and biogenesis; current therapeutic modalities and future strategies; epigenetic DNA methylation; histone modification; and non-coding RNAs and miRNAs; gaseous molecules and signaling pathways; gender differences; aging; and kidney dysfunction; glomerulosclerosis and renovascular remodelling following injury; gut– kidney axis and health; hypertensive; diabetic; and IgA nephropathy; inflammatory vs. reparatory macrophages and renal repair; ischemia and reperfusion injury; matrix protein; metalloproteinases; and their inhibitors; necrosis; necroptosis; apoptosis; pyroptosis; and ferroptosis; renal repair and regeneration

(This special issue belongs to the Section Molecular Biology)

Molecular Pathology, Diagnostics, and Therapeutics of Lung Disease

edited by

Toshimitsu Yamaoka

submission deadline 30 Jun 2026 | 4 articles | Viewed by 4713 | Submission Open

Keywords: pulmonary diseases; diagnostics; therapeutics

(This special issue belongs to the Section Molecular Medicine)

New Insights into Protein Aggregation in Condensed and Amyloid States

edited by

Eva Žerovnik

and

Veronika Stoka

submission deadline 30 Jun 2026 | 2 articles | Viewed by 4303 | Submission Open

Keywords: proteinopathies; protein aggregation; physico-chemical and biological properties of amyloid fibrils and protein condensates; signal and light transduction; interaction with lipid membranes; aggregating protein interactomes; bioinformatics and machine learning; molecular dynamics

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Mechanisms of Formation of Biomolecule Complexes: Theory, Experiment, Applications

edited by

Agata Pomorska

Aneta Michna

and

Maria Morga

submission deadline 30 Jun 2026 | 2 articles | Viewed by 4208 | Submission Open

Keywords: biomolecule complexes; biomolecule coacervates; complex stability; mechanisms of formation of biomolecule complexes; phase separation; application of biomolecule complexes in biomedical industry

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

The Biomarkers in Renal Diseases

edited by

Rosemary Wangensteen

and María Carmen Ruiz Fuentes

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3583 | Submission Open

Keywords: biomarkers; acute kidney injury; chronic kidney disease; microvesicles; exosomes

(This special issue belongs to the Section Molecular Biomarkers)

Advances in Pharmacognosy and Phytochemistry: From Molecular to Pre-Clinical Insights

edited by

Hilal Zaid

Zipora Tietel

and

Akhilesh K. Tamrakar

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3425 | Submission Open

Keywords: metabolomics; drug discovery; phytopharmacology; medicinal plants

(This special issue belongs to the Section Natural and Bio-derived Molecules)

New Insights into Stem Cell-Derived Exosomes in Human Health and Disease

edited by

Lubos Danisovic

submission deadline 30 Jun 2026 | 1 articles | Viewed by 3185 | Submission Open

Keywords: stem cells; exosomes; regenerative medicine; diagnostics

(This special issue belongs to the Section Cellular Biochemistry)

Impact of Exercise Physiology and Diet on Adipokines in Health and Diseases

edited by Aurora Daniele and

Ersilia Nigro

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2816 | Submission Open

Keywords: adipose tissue; adiponectin; adiponectin receptors; physical exercise; exercise; health; disease

(This special issue belongs to the Section Biological Factors)

Molecular Basis and Novel Treatment of Epilepsy

edited by

Fang Zheng

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2737 | Submission Open

Keywords: epilepsy; genetic basis; epileptogenesis; antiseizure drugs; novel treatment; translational research

(This special issue belongs to the Section Molecular Biology)

Bionanomaterials: Synthesis, Characterization, Toxicity and Biomedical Applications, 3rd Edition

edited by

Simona Clichici

and

Adriana Gabriela Filip

submission deadline 30 Jun 2026 | 3 articles | Viewed by 2712 | Submission Open

Keywords: nanoparticles; nano-alloys; graphene; nanotubes; hybrid nanomaterials; green synthesis; cytotoxicity; systemic toxicity; modulation of the biological impact; nanomaterials as diagnostic and therapeutic platforms; potential applications in medicine

(This special issue belongs to the Section Bio-Engineered Materials)

Mitochondria as a Target for Tissue Repair and Regeneration

edited by

Igor A. Prudovsky

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1852 | Submission Open

Keywords: mitochondria; trauma; tissue repair; regeneration; inflammation; mitochondrial DAMPs; mitochondrial biogenesis; mitophagy

(This special issue belongs to the Section Molecular Biology)

T Cell Ca²⁺ Signal Dynamics: An Emerging Landscape for Therapeutic Strategies

edited by David W. Thomas and

Marc André Lécuyer

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1632 | Submission Open

Keywords: T cell signaling; Ca signaling; TCR-activated signals; ER Ca release; ER Ca stores; store-operated Ca influx; ER Ca store depletion signals

(This special issue belongs to the Section Cellular Biochemistry)

Sperm Nuclear BASIC Proteins: From Chromatin Remodeling to Drug Development and Innovative Clinical Applications

edited by

Marina Piscopo

and

Carmen Di Giovanni

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1599 | Submission Open

Keywords: sperm nuclear basic proteins (SNBPs); spermatogenesis; epigenetics; drug development; chromatin remodeling; biomarkers of fertility; translational reproductive medicine

(This special issue belongs to the Section Cellular Biochemistry)

Lipid Signaling in Human Disease

edited by

Berit Johansen

and Felicity Ashcroft

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1465 | Submission Open

Keywords: lipid signaling pathways; membrane-derived lipid signaling molecules; inflammation mechanisms; cellular disease mechanisms; phospholipids; phospholipases; glycerophospholipids; sphingolipids

(This special issue belongs to the Section Lipids)

Design, Synthesis, and Evaluation of New Anticancer Substances and Radiopharmaceuticals

edited by

Monika Pitucha

and

Marta Rusek

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1312 | Submission Open

Keywords: synthesis; anticancer activity; radiopharamceuticals; organic compounds; medicinal chemistry

(This special issue belongs to the Section Chemical Biology)

Immune Response to Allergens

edited by

Brigita Gradauskiene

and

Sandra Sakalauskaite

submission deadline 30 Jun 2026 | Viewed by 1003 | Submission Open

Keywords: allergy; immune response; allergen; sensitization; molecular allergology; diagnostics; specific immunotherapy

(This special issue belongs to the Section Cellular Biochemistry)

Genetic Insights into Cardiomyopathy: From Mechanisms to Medicine

edited by Xiao Fan and Youngil Lee

submission deadline 30 Jun 2026 | 1 articles | Viewed by 856 | Submission Open

Keywords: cardiomyopathy; genetics; epigenetics; genomics; genotype– phenotype correlation; genetic penetrance; precision medicine; mitochondria; personalized treatment; gene therapy

(This special issue belongs to the Section Molecular Genetics)

Ocular Surface and Corneal Diseases: From Cellular and Molecular Biology to Therapeutic Strategies

edited by

Anat Galor

and Pragnya Rao Donthineni

submission deadline 30 Jun 2026 | 1 articles | Viewed by 701 | Submission Open

Keywords: dry eye disease; dry eye; aqueous tear deficiency; evaporative deficiency; ocular surface inflammation; tear osmolarity; epidemiology; limbal stem cell deficiency; neuropathic ocular pain; neurotrophic keratitis

(This special issue belongs to the Section Cellular Biochemistry)

Emerging Insights into the Role of Polyamines in Cellular Metabolism and Function

edited by

Cassandra E. Holbert

and

Tracy Murray Stewart

submission deadline 30 Jun 2026 | Viewed by 292 | Submission Open

Keywords: polyamine metabolism; putrescine; spermidine; spermine; polyamines in development; polyamines in health and disease; polyamines in cancer; polyamines in plant physiology

(This special issue belongs to the Section Cellular Biochemistry)

Soft Matter and Self-Assembly: From Biomaterials to Nanomaterials

edited by Caterina Ricci and

Maria Grazia Ortore

submission deadline 30 Jun 2026 | Viewed by 244 | Submission Open

Keywords: soft matter; self-assembly; biomaterials; nanomaterials; bioinspired materials; drug delivery; responsive materials; tissue engineering; nanotechnology; molecular organization

Unraveling the Mysteries of Muscle: Advances in Myogenesis, Physiology, and Wasting Disorders

edited by

Wan Lee

submission deadline 30 Jun 2026 | Viewed by 225 | Submission Open

Keywords: muscle biology; molecular mechanism; myogenesis; muscle physiology; muscle wasting; sarcopenia; cachexia; muscle-related pathologies

Exercise Immunology: Molecular Mechanisms and Health Applications

edited by

Dorota Kostrzewa-Nowak

Robert Nowak

, Michał Sławiński and

Patrizia Proia

submission deadline 30 Jun 2026 | Viewed by 194 | Submission Open

Keywords: post-effort immune response; lifestyle-associated molecular patterns; damage-associated molecular patterns; immune cell; cell signaling; cell death; growth factor; chemokines; cytokines; transcription factors

(This special issue belongs to the Section Molecular Biology)

Bacterial Molecular Biology: Stress Responses and Adaptation

edited by Alba Blesa, Lucía García Pastor and Mercedes Sánchez-Costa

submission deadline 30 Jun 2026 | Viewed by 189 | Submission Open

Keywords: bacterial stress response; adaptation; antimicrobial resistance; virulence; microbial persistence; extremophiles; environmental signalling; phenotypic plasticity; HGT; regulation networks

(This special issue belongs to the Section Molecular Biology)

Role of Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles in the Regenerative Medicine of Musculoskeletal System

edited by

Dimitrios Kouroupis

and

Enrico Ragni

submission deadline 30 Jun 2026 | Viewed by 155 | Submission Open

Keywords: mesenchymal stem/stromal cells; extracellular vesicles ; musculoskeletal regeneration ; immunomodulation ; anabolism ; cell therapy ; cell-free therapy ; secretome

Novel Biomarkers in Breast Cancer: Leveraging Multi-Omics and AI for Discovery and Validation

edited by Konstantinos Venetis,

Nicola Fusco

and Marianna D'Ercole

submission deadline 30 Jun 2026 | Viewed by 147 | Submission Open

Keywords: breast cancer; biomarkers; liquid biopsy; multi-omics; digital pathology

(This special issue belongs to the Section Molecular Biomarkers)

Recent Advances in Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases: 3rd Edition

edited by

Adriana Georgescu

submission deadline 30 Jun 2026 | Viewed by 143 | Submission Open

Keywords: cardiovascular disease; dyslipidemia; diabetes; obesity; inflammation; oxidative stress; biomarkers; microRNA; extracellular vesicles; cardiopulmonary disease

Non-Invasive Biomarker Screening in Cancer

edited by

Iqbal Mahmud

and F. G. Pinto

submission deadline 30 Jun 2026 | Viewed by 142 | Submission Open

Keywords: non-invasive biomarkers; cancer screening; metabolomics; lipidomics; proteomics; liquid biopsy; early detection; multiomics; precision oncology; diagnostic technologies

(This special issue belongs to the Section Molecular Biomarkers)

Molecular and Physiological Regulation of Biomechanical Signalling

edited by

Lars Kaestner

submission deadline 30 Jun 2026 | Viewed by 129 | Submission Open

Keywords: biomechanics; molecular signalling; mechanosensitive ion channels; Piezo1& 2; microfluidics

Endocrine, Immune and Molecular Biomarkers in Pain and Psychosomatic Disorders: Bridging Mechanisms and Medical Application

edited by

Nebojsa Nick Knezevic

and

Aleksandar Sič

submission deadline 30 Jun 2026 | Viewed by 125 | Submission Open

Keywords: personalized pain medicine; systems biology of pain; neuroendocrine regulation; molecular biomarkers; psychosomatic disorders

(This special issue belongs to the Section Biological Factors)

Forces Driving Macromolecular Recognition: Role in Drug Design and Discovery

edited by David P. Remeta and

Conceição A. Minetti

submission deadline 30 Jun 2026 | Viewed by 122 | Submission Open

Keywords: macromolecular recognition; drug design and discovery; biomolecular structure and dynamics; computational modeling; ligand– receptor binding energetics; drug-target interactions; thermodynamic forces; protein-ligand binding; drug discovery and optimization; protein-nucleic acid interactions; intrinsically disordered proteins; protein aggregation and disease

(This special issue belongs to the Section Chemical Biology)

Displaying special issue 301-350 on page 7 of 11.

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