Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Approaches to Harness Neuropathic Pain: Modulation of Glial Cells as a Therapeutic Strategy submission deadline 6 Dec 2026 | Viewed by 484 | Submission Open
Keywords: neuropathic pain; neuroinflammation; descending pain modulation; glial cells; pharmacological therapies; non-pharmacological therapies; microglia; astrocytes
Transcription Factors in Hematopoiesis and Immunity: From Development to Therapeutic Targeting
edited by Amiya Kumar Patra
submission deadline 7 Dec 2026 | 3 articles | Viewed by 5005 | Submission Open
Keywords: transcription factors; immune regulation; epigenetics; cytokines and chemokines; molecular interaction; immunodeficiency; allergy; leukemia and lymphoma; small molecule inhibitors; hematopoietic disorders
(This special issue belongs to the Section Molecular Biology)
Recent Molecular Research on Protein Structure and Function
edited by
submission deadline 15 Dec 2026 | 3 articles | Viewed by 4954 | Submission Open
Keywords: protein structure; protein function; molecular mechanisms; protein folding; structural biology
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Therapeutic Innovations in Musculoskeletal Disorders
edited by Fackson Mwale and Michael P. Grant
submission deadline 15 Dec 2026 | 1 articles | Viewed by 833 | Submission Open
Keywords: musculoskeletal; disorders; therapeutics; inflammation; degeneration
(This special issue belongs to the Section Molecular Medicine)
Innovative Approaches and New Directions in Drug Design and Chemical Biology
edited by Arshad Ansari and Avinash Gothwal
submission deadline 15 Dec 2026 | Viewed by 293 | Submission Open
Keywords: drug design; chemical biology; medicinal chemistry; protein–ligand interactions; chemical probes; target validation; computational drug discovery; drug discovery; structure-based design; novel therapeutics
(This special issue belongs to the Section Chemical Biology)
Molecular Mechanisms and Regulation of Kidney Disease
edited by
submission deadline 15 Dec 2026 | Viewed by 279 | Submission Open
Keywords: chronic kidney disease; acute kidney injury; inflammation; renal repair and regeneration; gene expression; epigenetic mechanisms; systems biology; mathematical modeling
(This special issue belongs to the Section Biological Factors)
Adenosine and Its Receptors: Emerging Targets in Neurodegenerative Diseases
edited by
submission deadline 15 Dec 2026 | Viewed by 240 | Submission Open
Keywords: adenosine; adenosine receptors; neuroinflammation; neurodegenerative diseases
(This special issue belongs to the Section Molecular Biology)
Neuromodulation of Hippocampal Circuits in Health and Disease
edited by Costas Papatheodoropoulos
submission deadline 15 Dec 2026 | Viewed by 222 | Submission Open
Keywords: neuromodulation; hippocampus; dopamine; serotonin; acetylcholine; norepinephrine; endocannabinoids; adenosine; oxytocin; opioids; brain rhythms; synaptic transmission; synaptic plasticity; behavior; neuropsychiatric disorders; neurological diseases
(This special issue belongs to the Section Biological Factors)
Helicases in DNA Repair: From Molecular Mechanisms to Medical and Biotechnological Applications
edited by Li Fan
submission deadline 16 Dec 2026 | 1 articles | Viewed by 2116 | Submission Open
Keywords: DNA unwinding; DNA damage response; damage verification; genetic disease; premature aging; cancer; chemotherapy; gene therapy
(This special issue belongs to the Section Molecular Genetics)
The Role of Scavenger Receptors in Health and Disease
edited by and Mihail E. Hinescu
submission deadline 16 Dec 2026 | 2 articles | Viewed by 2001 | Submission Open
Keywords: scavenger receptor; CD36; lipid scavenger; cell-to-matrix adhesion; metastasis; neoangiogenesis; biomarker
(This special issue belongs to the Section Biological Factors)
Ion Homeostasis and Metal Biology in Diseases
edited by and Zhenglin Yang
submission deadline 17 Dec 2026 | Viewed by 178 | Submission Open
Keywords: metal ion homeostasis; metal biology; metalloproteins; metal-protein interactions; ion signaling and redox regulation; multi-metal crosstalk; bioinorganic mechanisms in metal biology; metal-targeted therapeutics; metal sensing methods; metals as medicines
(This special issue belongs to the Section Biological Factors)
Metagenomics and Genomics of Marine Organisms submission deadline 18 Dec 2026 | 1 articles | Viewed by 1547 | Submission Open
Keywords:
  • metagenomics
  • genomics
  • viruses
  • bacteria
  • symbiosis
  • microbiome
Melanin Biosynthesis and Degradation: Molecular Mechanisms and Pathophysiological Roles
edited by Kazumasa Wakamatsu
submission deadline 18 Dec 2026 | Viewed by 205 | Submission Open
Keywords: melanogenesis; tyrosinase-related proteins (TRPs); melanosomal turnover; autophagy-mediated degradation; pigmentary homeostasis; molecular signalling pathways; pathophysiological dysregulation
(This special issue belongs to the Section Chemical Biology)
Inflammation and Immunity in Lung Disease
edited by
submission deadline 20 Dec 2026 | 7 articles | Viewed by 5717 | Submission Open
Keywords: lung; infection; inflammation; host defense; cytokine release syndrome; genetic deficiency
(This special issue belongs to the Section Cellular Biochemistry)
The Urokinase System in Cancer: From Stress Responses to Therapeutic Targeting
edited by and
submission deadline 20 Dec 2026 | 2 articles | Viewed by 3519 | Submission Open
Keywords: urokinase plasminogen activator; PAI1; urokinase plasminogen activator receptor; transcription; regulation; cancer; migration; invasion; stress
Recent Advances in Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases: 3rd Edition
edited by
submission deadline 20 Dec 2026 | Viewed by 436 | Submission Open
Keywords: cardiovascular disease; dyslipidemia; diabetes; obesity; inflammation; oxidative stress; biomarkers; microRNA; extracellular vesicles; cardiopulmonary disease
Molecular Mechanism of Viral Infection and Host Immunity in Transplantation
edited by Eva Mischak Weissinger
submission deadline 20 Dec 2026 | Viewed by 302 | Submission Open
Keywords: allogeneic stem cell/or solid organ transplantation; immunosuppressed host; immune reconstitution; virus reactive/specific cytotoxic T-/NK-cells; immune reconstitution post-transplantation
(This special issue belongs to the Section Molecular Medicine)
Structural Biology of Protein, 2nd Edition
edited by
submission deadline 20 Dec 2026 | Viewed by 76 | Submission Open
Keywords: structural characterization; protein structure–function paradigm; biophysical techniques; computational methods; conformational dynamics; drug discovery; protein–protein interactions
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Impact of Lifestyle Changes on Biomolecular Profiles Across the Lifespan submission deadline 30 Dec 2026 | 1 articles | Viewed by 1641 | Submission Open
Keywords: lifestyle; microRNAs; disease
(This special issue belongs to the Section Chemical Biology)
Lung Diseases: From Molecular Mechanisms to Therapeutics
edited by
submission deadline 30 Dec 2026 | 1 articles | Viewed by 860 | Submission Open
Keywords: interstitial pneumonia; COPD; lung diseases; lung cancer; therapeutic targets; lifestyle factors; immunology; epigenetics; biomarkers
(This special issue belongs to the Section Molecular Medicine)
Linking Excess Adiposity to Cancer: Molecular and Cellular Perspectives
edited by Marion Korach-André and Amena Archer
submission deadline 30 Dec 2026 | Viewed by 274 | Submission Open
Keywords: obesity; cancer; tumor microenvironment; adipose tissue; liver; inflammation; microbiota; metabolic reprogramming; novel therapeutic; omics
(This special issue belongs to the Section Cellular Biochemistry)
Feature Papers in the Natural and Bio-Derived Molecules Section submission deadline 31 Dec 2026 | 14 articles | Viewed by 98276 | Submission Open
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Insights from the Editorial Board Members
edited by
submission deadline 31 Dec 2026 | 13 articles | Viewed by 51024 | Submission Open
Keywords: structure and function; bioactive and biogenic substances; molecular mechanisms; biomaterials
Cell Biology and Biomedical Application of Galectins submission deadline 31 Dec 2026 | 7 articles | Viewed by 23025 | Submission Open
Keywords: galectins; cell differentiation; stem cells; apoptosis; autophagy; cell adhesion; glycobiology; post-translational modifications; transmembrane signaling; protein trafficking; cancer; heart diseases; fibrosis; inflammation; targeted therapeutics; galectin inhibitors
(This special issue belongs to the Section Chemical Biology)
Antitumor Agents from Natural Sources 2026 submission deadline 31 Dec 2026 | 6 articles | Viewed by 20340 | Submission Open
Keywords: antitumor agents; natural sources; cancer prevention and therapy
(This special issue belongs to the Section Natural and Bio-derived Molecules)
State of the Art and Perspectives in Retinal Pigment Epithelium submission deadline 31 Dec 2026 | 4 articles | Viewed by 17319 | Submission Open
Keywords: retinal pigment epithelium; innovative treatments/therapeutic approaches; retinal diseases; bioactive molecules; eye delivery strategy
(This special issue belongs to the Section Cellular Biochemistry)
Antimicrobial Peptides in Nature: Inspiration for Rationally Designed Antimicrobials
edited by and
submission deadline 31 Dec 2026 | 6 articles | Viewed by 14817 | Submission Open
Keywords: antimicrobial resistance; antimicrobial peptides; rational design of peptides; antimicrobial peptide synthesis; peptidomimetic antimicrobial agents
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Matrix Metalloproteinases: Mechanisms, Functions and Therapeutic Potential
edited by and Muhammad Faheem
submission deadline 31 Dec 2026 | 2 articles | Viewed by 14058 | Submission Open
Keywords: matrix metalloproteinases; endopeptidases; MMP inhibitor; tissue homeostasis; disease progression
(This special issue belongs to the Section Enzymology)
Mechanisms of Kidney Injury and Treatment Modalities
edited by Utpal Sen
submission deadline 31 Dec 2026 | 3 articles | Viewed by 13588 | Submission Open
Keywords: acute and chronic kidney injury; autophagy and mitophagy; bioenergetics, mitochondrial damage, and biogenesis; current therapeutic modalities and future strategies; epigenetic DNA methylation, histone modification, and non-coding RNAs and miRNAs; gaseous molecules and signaling pathways; gender differences, aging, and kidney dysfunction; glomerulosclerosis and renovascular remodelling following injury; gut–kidney axis and health; hypertensive, diabetic, and IgA nephropathy; inflammatory vs. reparatory macrophages and renal repair; ischemia and reperfusion injury; matrix protein, metalloproteinases, and their inhibitors; necrosis, necroptosis, apoptosis, pyroptosis, and ferroptosis; renal repair and regeneration
(This special issue belongs to the Section Molecular Biology)
Molecular Biomarkers in Cardiology 2026
edited by
submission deadline 31 Dec 2026 | 4 articles | Viewed by 12773 | Submission Open
Keywords: cardiovascular diseases; cardiovascular pathology and histology; carotid plaques and histology; endothelium and endothelial dysfunction; veins diseases; arrhythmias; heart
(This special issue belongs to the Section Molecular Biomarkers)
Unraveling the Complexity of Autoimmune and Autoinflammatory Skin Diseases: From Molecular Pathways to Targeted Therapies submission deadline 31 Dec 2026 | 1 articles | Viewed by 10369 | Submission Open
Keywords: autoimmune/autoinflammatory skin diseases; omics; bioinformatics; pathogenesis; tailored medicine
(This special issue belongs to the Section Molecular Genetics)
Molecular Advances in Rett Syndrome and Other Chromatin Related Disorders
edited by and Salvatore Fioriniello
submission deadline 31 Dec 2026 | 3 articles | Viewed by 9952 | Submission Open
Keywords: Rett syndrome and other chromatin disorders; epigenetic diseases; molecular alterations in Rett syndrome and other chromatin diseases; novel genes associated with chromatin disorders; MeCP2-mediated molecular mechanisms; roles of epigenetic modulators in chromatin-related diseases; preclinical studies for chromatin diseases; novel diagnostic, prognostic and therapeutic approaches for chromatin disorders
(This special issue belongs to the Section Molecular Medicine)
Feature Papers in "Molecular Biology" Section 2026 submission deadline 31 Dec 2026 | 7 articles | Viewed by 9088 | Submission Open
Keywords: mechanobiology; cellular processes including metabolism, proliferation and motility; molecular motors and forces; molecular and biophysical techniques; organelle and membrane transport; exo- and endosomal trafficking; cell and biophysical signal transduction; the biomolecular synthesis of proteins, protein folding and post-translational modification of proteins and macromolecular assemblies
(This special issue belongs to the Section Molecular Biology)
Advances in Galectins
edited by Anu Paul and Diyoly Ayona
submission deadline 31 Dec 2026 | 3 articles | Viewed by 8927 | Submission Open
Keywords: galectins; carbohydrate-binding proteins; galectin–microbe
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Industrial Microorganisms and Enzyme Technologies
edited by
submission deadline 31 Dec 2026 | 5 articles | Viewed by 7424 | Submission Open
Keywords: enzyme engineering; enzyme kinetics and optimization; industrial biotechnology; industrial microbiology; microbial metabolism
(This special issue belongs to the Section Enzymology)
Pluripotent Stem Cells: From Basic Research to Therapeutic Applications submission deadline 31 Dec 2026 | 2 articles | Viewed by 7401 | Submission Open
Keywords: pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells; organoids; differentiation; regenerative medicine; disease modeling; cell therapy; therapeutic applications
(This special issue belongs to the Section Molecular Biology)
Vertebrate Comparative Genomics
edited by Ya-Xiong Tao and
submission deadline 31 Dec 2026 | 9 articles | Viewed by 6903 | Submission Open
Keywords: vertebrate; comparative genomics; physiology; biochemistry; pathophysiology; protein structure-function; gene
(This special issue belongs to the Section Molecular Genetics)
Studies of Protein Dynamics, Interactions, and Concentration by Fluorescence Fluctuation Correlation Spectroscopy (FFCS)
edited by Jieqiong Lou and Elvis Pandžić
submission deadline 31 Dec 2026 | 6 articles | Viewed by 6890 | Submission Open
Keywords: fluorescence fluctuation correlation spectroscopy (FFCS); fluorescence correlation spectroscopy (FCS); image correlation spectroscopy (ICS); pair correlation function (pCF) analysis; line-scan correlation; protein dynamics; molecular diffusion; molecular flow; confinement dynamics; protein–protein interactions; membrane organization; intracellular transport; molecular crowding; spatiotemporal fluctuations; concentration heterogeneity; live-cell imaging; single-molecule analysis; quantitative fluorescence microscopy; biophysics; super-resolution fluctuation analysis
Epigenetic Regulation of Cell Differentiation During Development and Disease: From Vascular Plasticity to Immune Signaling submission deadline 31 Dec 2026 | 3 articles | Viewed by 6795 | Submission Open
Keywords: vascular smooth muscle cells; cell phenotypic change; epigenetics; gene expression regulation; cell differentiation
(This special issue belongs to the Section Molecular Biology)
Advances in Pharmacognosy and Phytochemistry: From Molecular to Pre-Clinical Insights submission deadline 31 Dec 2026 | 2 articles | Viewed by 6772 | Submission Open
Keywords: metabolomics; drug discovery; phytopharmacology; medicinal plants
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Iron Metabolism in Cells submission deadline 31 Dec 2026 | 5 articles | Viewed by 6667 | Submission Open
Keywords: iron metabolism; iron-related proteins; iron uptake; iron storage; mitochondrial iron metabolism; iron sensing mechanism; ferroptosis
(This special issue belongs to the Section Cellular Biochemistry)
Molecular Basis of Pathogenesis in Autoimmune Diseases submission deadline 31 Dec 2026 | 1 articles | Viewed by 5766 | Submission Open
Keywords: autoimmune diseases; molecular pathogenesis; genetic determinants; signaling pathways; immunopathology; therapeutic targets; novel molecular targets
(This special issue belongs to the Section Molecular Medicine)
Metal-Based Complexes in Medicine: From Therapeutics to Diagnostics and Theranostics submission deadline 31 Dec 2026 | 4 articles | Viewed by 5548 | Submission Open
Keywords: anticancer metal complexes; antitumor metallodrugs; antimicrobial agents; antiviral metallodrugs; medicinal inorganic chemistry; bioinorganic chemistry; computational design; molecular dynamics; docking; spectroscopic methods; NMR; mechanistic studies; rational drug development; synthesis; biological evaluation; drug delivery; experimental; in vitro; in vivo; theranostics; medicinal imaging
Advances in Membrane Proteins: From Structure to Function and Molecular Engineering
edited by and Renhong Yan
submission deadline 31 Dec 2026 | 3 articles | Viewed by 5489 | Submission Open
Keywords: membrane transport; transmembrane signaling; membrane protein complex; membrane-based reactions; membrane and protein interaction; regulation of membrane proteins; membrane protein design; membrane protein engineering
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Ocular Surface and Corneal Diseases: From Cellular and Molecular Biology to Therapeutic Strategies
edited by and Pragnya Rao Donthineni
submission deadline 31 Dec 2026 | 3 articles | Viewed by 5333 | Submission Open
Keywords: dry eye disease; dry eye; aqueous tear deficiency; evaporative deficiency; ocular surface inflammation; tear osmolarity; epidemiology; limbal stem cell deficiency; neuropathic ocular pain; neurotrophic keratitis
(This special issue belongs to the Section Cellular Biochemistry)
DNA Damage Repair and Cancer Therapeutics
edited by
submission deadline 31 Dec 2026 | 3 articles | Viewed by 4819 | Submission Open
Keywords: DNA damage repair; cancer therapy; genomic stability; targeted therapy; biomarkers
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Recent Advances in Fluorescent Probes: From Structure Design to Biological Applications
edited by Yalin Qi
submission deadline 31 Dec 2026 | 2 articles | Viewed by 4237 | Submission Open
Keywords: fluorescent probes; organic small molecule fluorescent probes; drug discovery; disease detection
(This special issue belongs to the Section Chemical Biology)
Molecular, Cellular, and Blood Biomarkers in Diagnosis, Prognosis, Monitoring, and Treatment: 2nd Edition
edited by , and Xavier Gabaldó Barrios
submission deadline 31 Dec 2026 | 3 articles | Viewed by 4047 | Submission Open
Keywords: biomarkers; infectious diseases; laboratory medicine; non-communicable diseases
(This special issue belongs to the Section Molecular Biology)
Biomolecular Sciences and Precision Medicine in Vascular Disease
edited by
submission deadline 31 Dec 2026 | 3 articles | Viewed by 3952 | Submission Open
Keywords: precision medicine; vascular disease; vascular surgery
(This special issue belongs to the Section Molecular Medicine)
Genomic Instability: Insights into Molecular Mechanisms, Human Diseases, and Therapies
edited by
submission deadline 31 Dec 2026 | 2 articles | Viewed by 3383 | Submission Open
Keywords: genome instability; DNA damage response; cancer; therapy; diagnosis
(This special issue belongs to the Section Molecular Genetics)
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