Natural Product for the Interventions of Chronic Diseases: From Source to Therapy—2nd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 865

Special Issue Editor

School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China
Interests: natural products; drug discovery; pharmacognosy; inflammation; nanotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, titled "Natural Product for the Interventions of Chronic Diseases: From Source to Therapy—2nd Edition", invites innovative research works that bridge the gap between the natural world and therapeutic applications for chronic conditions. Chronic diseases, such as rheumatoid arthritis, diabetes, and various forms of cancer, represent a growing burden on global health. Natural products have historically provided a rich source of pharmacological agents, and their role in chronic disease intervention remains a rich area for exploration. This Special Issue will focus on the discovery, analysis, and application of natural compounds in the prevention and treatment of chronic diseases. Submissions should highlight advancements in the selective extraction and refinement of bioactive components, the evaluation of their therapeutic potential, and the exploration of the molecular mechanisms through which these compounds exert their effects. We welcome studies that employ state-of-the-art techniques for the identification and enhancement of the therapeutic properties of natural products, as well as research that offers insight into the pharmacodynamics and pharmacokinetics of these potential treatments. By integrating traditional understanding with modern scientific approaches, this Special Issue aims to further the development of natural products as efficacious agents in the long-term management of chronic diseases. This Special Issue only includes research “with defined molecular compound”.

Dr. Qilei Chen
Guest Editor

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Keywords

  • natural products
  • chronic diseases
  • drug discovery
  • pharmacodynamics
  • pharmacokinetics
  • nanotechnology

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Published Papers (1 paper)

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Research

21 pages, 40018 KB  
Article
D-Pinitol Mitigates Renal Senescence via Targeting the SARM1-cGAS-STING Signaling Axis to Restore Mitochondrial Function and Dampen Inflammatory Responses
by Xiaofan Yin, Kaizhi Wen, Kena Yu, Zhengxin Liu and Weiming He
Biomedicines 2026, 14(5), 1092; https://doi.org/10.3390/biomedicines14051092 - 12 May 2026
Viewed by 482
Abstract
Background: Renal aging represents a pivotal contributor to the pathogenesis and progression of age-related kidney disorders. D-Pinitol (DP), a bioactive cyclitol naturally present in food plants, exhibits multiple beneficial biological activities. Nevertheless, its role in counteracting renal aging remains unclear. Methods: [...] Read more.
Background: Renal aging represents a pivotal contributor to the pathogenesis and progression of age-related kidney disorders. D-Pinitol (DP), a bioactive cyclitol naturally present in food plants, exhibits multiple beneficial biological activities. Nevertheless, its role in counteracting renal aging remains unclear. Methods: This study employed both in vitro (HK-2 cells) and in vivo (C57BL/6J mice) models of D-galactose (DG)-induced renal aging. A panel of experimental approaches was applied to characterize the protective effects and molecular mechanisms of DP against renal aging, including Western blot, qPCR, ELISA, transcriptomic profiling, transmission electron microscopy, surface plasmon resonance (SPR), immunohistochemistry, and immunofluorescence staining. Results: DP significantly attenuated DG-induced renal aging-like changes in vitro and in vivo by preserving mitochondrial function and alleviating inflammatory responses. Transcriptomic analysis suggested SARM1 as a potential key target responsible for the beneficial effects of DP. In DG-induced aging models, SARM1 was remarkably upregulated in a tubule-specific pattern and acted as a critical mediator of mitochondrial dysfunction. Damaged mitochondria released mtDNA, which further activated the cGAS–STING innate immune signaling pathway, consequently promoting the senescence-associated secretory phenotype (SASP) and renal inflammation. Mechanistically, molecular docking and related assays suggested that DP may stabilize the auto-inhibitory conformation of SARM1, thereby potentially preventing its activation. Conclusions: DP attenuates DG-induced renal aging-like changes via suppressing the SARM1–cGAS–STING axis, thereby restoring mitochondrial homeostasis and mitigating inflammation. Given the lack of effective interventions targeting renal aging, these findings suggest SARM1 as a novel potential therapeutic target for renal aging and highlight DP as a promising food-derived anti-aging ingredient for renal protection. Full article
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