Precision Approaches in the Diagnosis and Management of Inflammatory Bowel Disease
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 19
Special Issue Editor
Interests: Inflammatory Bowel Disease (IBD); integrating systems biology; microbiome–immune interactions; immunometabolism; dietary and pharmacologic interventions
Special Issue Information
Dear Colleagues,
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is a chronic immune-mediated disorder of the gastrointestinal tract, marked by relapsing inflammation, unpredictable symptom patterns, and heterogeneous treatment responses. While current therapies have improved disease control, many patients experience only partial remission or develop treatment-related complications that affect long-term outcomes. In addition to intestinal inflammation, growing evidence highlights the broader systemic impact of IBD and its therapies, including increased risk of metabolic dysfunction, weight gain, insulin resistance, and hepatobiliary disease. These complications not only affect overall health but may also contribute to disease progression. Addressing these challenges requires more integrative and personalized approaches to care. Recent advances in noninvasive diagnostics, microbiome-targeted therapies, dietary interventions, and multi-omics profiling are transforming how we understand and manage IBD. Alongside these, clinical strategies such as therapeutic repurposing, combination treatments, personalized dosing, and biomarker-based decision-making are helping to drive a broader shift toward precision medicine. This Special Issue aims to highlight the latest research in the diagnosis, monitoring, and treatment of IBD, with a focus on individualized, mechanistically guided strategies. We welcome contributions from researchers and clinicians working across disciplines to advance understanding of IBD pathophysiology and improve patient-centered outcomes.
Dr. Jiayu Ye
Guest Editor
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Keywords
- inflammatory bowel disease
- ulcerative colitis
- Crohn’s disease
- precision medicine
- microbiome-based therapy
- noninvasive diagnostics
- stratified therapeutic response
- immunometabolism
- system immunology
- therapeutic repurposing
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