Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.8
3.9
Journals
Biomedicines
Special Issues
Obesity and Obesity-Related Pathology
share announcement

Obesity and Obesity-Related Pathology

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 798

Special Issue Editor

Dr. Adriana Grigoraș

E-Mail Website
Guest Editor
Department of Morphofunctional Sciences, “Grigore T. Popa” University of Medicine and Pharmacy, University Street No. 16, Iasi, Romania
Interests: obesity-related pathology; tumor pathology; histology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Currently, obesity is defined as a chronic, complex disease characterized by excessive fat deposits. The prevalence of obesity and obesity-associated conditions has continued to increase over the last few decades, negatively impacting societies and economies. Obesity and its associated chronic diseases can also affect quality of life and lead to increased mortality, primarily due to cardiovascular diseases and malignancies. Dysfunctional expanded adipose tissue has been shown to play a pivotal role in obesity-related pathology development. Consequently, a main research priority in obesity is the development of new therapeutic tools targeting the dysfunctional adipose tissue that occurs in patients who are obese.

This Special Issue aims to provide a platform for updated studies on obesity and obesity-related pathologies, ranging from diabetes mellitus, depression, cardiovascular diseases, and chronic kidney diseases to cancer. Reviews and research exploring the cellular and molecular factors that modulate obesity and obesity-related pathologies are welcome for submission.

Dr. Adriana Grigoraș
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • obesity-related cardiovascular diseases
  • obesity-related chronic kidney diseases
  • diabetes mellitus
  • depression
  • obesity-related cancer
  • adipose tissue
  • adipocytes
  • cancer-associated adipocytes
  • obesity therapies

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

15 pages, 847 KB  
Article
Selective Mid-Wall Cardiac Dysfunction in Obesity: The Role of Muscle-to-Fat Balance
by Karolina Angela Sieradzka Uchnár, Ingrid Schusterová, Štefan Tóth, Tibor Porubän, Mariana Dvorožňáková and Pavol Fülöp
Biomedicines 2025, 13(12), 3083; https://doi.org/10.3390/biomedicines13123083 - 14 Dec 2025
Viewed by 418
Abstract
Objective: This study aims to analyze relationships between body composition, biochemical parameters, and cardiac function in young adults to identify mechanisms of cardiac dysfunction in obesity. Methods: This is a cross-sectional study of 60 young adults (mean age 20.4 years) divided into healthy [...] Read more.
Objective: This study aims to analyze relationships between body composition, biochemical parameters, and cardiac function in young adults to identify mechanisms of cardiac dysfunction in obesity. Methods: This is a cross-sectional study of 60 young adults (mean age 20.4 years) divided into healthy (n = 29) and overweight/obese (n = 31) groups. Body composition was assessed using bioelectrical impedance analysis. We calculated the SMM-to-Fat ratio (skeletal muscle mass %/body fat %) as a continuous composite metric. Cardiac function was evaluated using 3D speckle-tracking echocardiography, with a 3D global circumferential strain pre-specified as the primary endpoint. Results: The obese group showed unfavorable body composition with lower SMM% (38.0 ± 10.8 vs. 47.1 ± 5.6%), higher body fat% (28.3 ± 12.6 vs. 16.0 ± 8.3%), and lower SMM-to-Fat ratio (2.1 ± 2.3 vs. 4.8 ± 5.1; all p < 0.001). C-peptide was 75% higher (p < 0.001), indicating compensatory hyperinsulinemia. The primary endpoint showed impairment in the obese group (−19.8 ± 4.7 vs. −22.2 ± 2.9%; p = 0.023, d = 0.61), while longitudinal strain was preserved, indicating selective mid-wall dysfunction. The SMM-to-Fat ratio demonstrated a stronger association with circumferential strain (r = −0.467, p = 0.008) than SMM% alone (r = −0.414, p = 0.021) and remained an independent predictor in multivariable analysis (β = −0.88, p = 0.019), whereas SMM% did not achieve significance (p = 0.159). Comprehensive analysis revealed correlation reversal across all body composition parameters between groups, with minerals% and total body water% emerging as additional independent predictors. Conclusions: Young obese adults exhibit selective mid-wall cardiac dysfunction. The SMM-to-Fat ratio, representing muscle–adiposity balance, is superior to SMM% alone for predicting cardiac dysfunction. Our findings suggest that the relative balance, rather than absolute muscle mass, determines cardiac health in obesity, with implications for body composition assessment and intervention strategies. Full article
(This article belongs to the Special Issue Obesity and Obesity-Related Pathology)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop