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Special Issues

Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Unleashing the Power of Innovative Nanoparticles for Enhanced Radiation Therapy
edited by Fangchao Jiang
submission deadline 31 Jul 2026 | Viewed by 337 | Submission Open
Keywords: nanomedicine; drug delivery; radiation therapy; nanotheranostics; nanoparticles; cancer treatment; biomaterial
(This special issue belongs to the Section Nanomedicine and Nanobiology)
Advances in the Diagnosis and Interventional Management of Peripheral Artery Disease: Emerging Technologies, Evidence, and Clinical Pathways
edited by Ioannis Skalidis
submission deadline 31 Jul 2026 | 1 articles | Viewed by 334 | Submission Open
Keywords: peripheral artery disease; peripheral interventions; atherosclerosis; angioplasty; diagnosis and treatment
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances in Wound Healing
edited by and
submission deadline 31 Jul 2026 | Viewed by 325 | Submission Open
Keywords: wound healing; scar and keloid; diabetic ulcers; multi-omics analysis for wound healing; biomaterials for wound healing; tissue engineering for wound healing; wound infection management; clinical trials and cases of wound healing
(This special issue belongs to the Section Molecular and Translational Medicine)
Novel Strategies for Oncogene-Addicted Lung Cancers: Not Rare Anymore submission deadline 31 Jul 2026 | Viewed by 246 | Submission Open
Keywords: target therapy; EMT; biomarkers; cancer mutations; preclinical models
(This special issue belongs to the Section Cancer Biology and Oncology)
Structure-Based Drug Molecule Design and Organic Synthesis
edited by
submission deadline 31 Jul 2026 | Viewed by 168 | Submission Open
Keywords: molecular modeling; drug discovery; medicinal chemistry; structure-based (SB) drug design; artificial intelligence in drug design; software development for drug design; teaching methods in drug design
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
RNA Therapy in Cancer Treatment: From Design to Clinical Translation
edited by Zhouxiao Li
submission deadline 31 Jul 2026 | Viewed by 155 | Submission Open
Keywords: mRNA vaccines; RNA interference (siRNA/miRNA); non-coding RNA therapeutics; lipid nanoparticles (LNPs); tumor microenvironment; neoantigen targeting; combination immunotherapy; clinical translation
(This special issue belongs to the Section Gene and Cell Therapy)
Diagnostic Biomarkers and Novel Therapeutics Targets for Fragile X Syndrome, Autism Spectrum Disorders and Genetic Neurodevelopmental Diseases: Advances and Challenges, 2nd Edition
edited by Yolanda De Diego-Otero and Rocio Calvo-Medina
submission deadline 31 Jul 2026 | Viewed by 154 | Submission Open
Keywords: fragile X syndrome; autism spectrum disorders; neurodevelopmental disorders; developmental neuroscience; cognitive development
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Dopamine and Androgen Receptor Signaling: Novel Insights in Cancer Biology
edited by Srijan Acharya
submission deadline 31 Jul 2026 | Viewed by 146 | Submission Open
Keywords: dopamine signaling; androgen receptor; cancer biology; hormone-sensitive tumors; signal transduction; tumor microenvironment; neurotransmitters in cancer; prostate cancer; breast cancer; targeted therapy
(This special issue belongs to the Section Cancer Biology and Oncology)
Biomedical Applications of Microfluidics
edited by
submission deadline 31 Jul 2026 | Viewed by 143 | Submission Open
Keywords: microfluidics; organ-on-a-chip; lab-on-a-chip; disease modeling; regenerative medicine; cancer immunotherapy; biosensors; mathematical modeling; AI/ML; realtime sensing
(This special issue belongs to the Section Biomedical Engineering and Materials)
Skeletal Muscle Ageing: From Molecular Mechanism to Treatment
edited by Can Cui and
submission deadline 31 Jul 2026 | Viewed by 132 | Submission Open
Keywords: skeletal muscle aging; sarcopenia; muscle regeneration; neuromuscular degeneration; molecular mechanisms of aging; mitochondrial dysfunction; inflammation and aging; therapeutic interventions; exercise and muscle health; musculoskeletal disorders in aging
(This special issue belongs to the Section Molecular and Translational Medicine)
Esophageal Cancer: Pathogenesis and Therapeutic Strategies submission deadline 31 Jul 2026 | Viewed by 94 | Submission Open
Keywords: ESCC; EACC; biomarkers; transcription factors; signaling pathways; immune cells; metabolism; animal model; cell lineage and gender
(This special issue belongs to the Section Cancer Biology and Oncology)
Molecular Research of Chronic Kidney Disease
edited by Jingyuan Xie
submission deadline 31 Jul 2026 | Viewed by 91 | Submission Open
Keywords: chronic kidney disease; molecular mechanisms; biomarker discovery; inflammation; fibrosis; genetic kidney disease; glomerulonephritis; diabetic nephrology
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances in Cardiac Dysfunction: From Early Detection to Innovative Therapies
edited by
submission deadline 31 Jul 2026 | Viewed by 75 | Submission Open
Keywords: cardiac dysfunction; heart failure; early detection; advanced heart failure; advanced cardiac imaging; biomarkers; innovative therapies; risk stratification; precision medicine
(This special issue belongs to the Section Molecular and Translational Medicine)
Inflammatory Bowel Disease: Pathomechanisms, Diagnostics, and Novel Therapeutic Strategies
edited by
submission deadline 31 Jul 2026 | Viewed by 75 | Submission Open
Keywords: inflammatory bowel disease; Crohn’ s disease; bowel inflammation; targeted therapy
(This special issue belongs to the Section Molecular and Translational Medicine)
Advancing Precision Radiation Oncology in Head and Neck Cancers
edited by
submission deadline 31 Jul 2026 | Viewed by 73 | Submission Open
Keywords: precision radiation oncology; head and neck cancers; oncogenetics; genomic biomarkers; radiosensitivity; adaptive radiotherapy; artificial intelligence; immunotherapy integration; proton therapy; deescalation strategies
(This special issue belongs to the Section Cancer Biology and Oncology)
Metabolic Diseases—New Markers and Treatment Pathways
edited by Anna Różańska-Walędziak
submission deadline 31 Jul 2026 | Viewed by 68 | Submission Open
Keywords: metabolic diseases; diabetes; obesity; biomarkers; anti-diabetic medications
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Advanced Single-Cell Sequencing in Diseases
edited by Sedat Kacar
submission deadline 31 Jul 2026 | Viewed by 67 | Submission Open
Keywords: single-cell sequencing; bioinformatics analysis; spatial transcriptomics; cellular heterogeneity; data-driven discovery; disease biology
(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)
Cardiac Arrhythmias and Arrhythmogenic Disorders: Pathomechanisms, Diagnostics and Novel Treatment Options
edited by Michela Casella and
submission deadline 31 Jul 2026 | Viewed by 65 | Submission Open
Keywords: arrhythmias; arrhythmogenic disorders; cardiomyopathies; genetics; cardiac MRI; atrial fibrillation; premature ventricular contraction; ventricular tachycardia; catheter ablation
(This special issue belongs to the Section Molecular and Translational Medicine)
Periodontal Disease: From Pathophysiology to Novel Therapeutic Approaches—2nd Edition
edited by
submission deadline 31 Jul 2026 | Viewed by 63 | Submission Open
Keywords: periodontal disease; oral microbiome; dysbiosis; artificial intelligence (AI); personalized therapeutic interventions
(This special issue belongs to the Section Molecular and Translational Medicine)
Extracellular Vesicles for Diagnosis and Therapy of Human Diseases, 2nd Edition
edited by
submission deadline 31 Jul 2026 | Viewed by 61 | Submission Open
Keywords: human diseases; extracellular vesicles; biomarkers; diagnosis; prognosis; therapeutic targets; therapeutic applications; EV engineering; physiology; pathology
(This special issue belongs to the Section Molecular and Translational Medicine)
Insights into Musculoskeletal Diseases
edited by
submission deadline 31 Jul 2026 | Viewed by 60 | Submission Open
Keywords: musculoskeletal diseases; myopathies; tendinopathy; tissue engineering; echo-guided injection; regenerative medicine
(This special issue belongs to the Section Molecular and Translational Medicine)
Rewiring Immune Fate: Immunometabolic and Epigenetic Mechanisms in Therapeutic Immunomodulation in Inflammation, Aging, and Cancer submission deadline 31 Jul 2026 | Viewed by 60 | Submission Open
Keywords: immunotherapy; cell therapy; immunometabolism; epigenetic reprogramming; chronic inflammation; immunosenescence; anti-cancer immunity; regeneration of the immune system; system biology of immunometabolism; tumor microenvironment; neuroimmune communication; graft versus host diseases; stromal regulation of structure and function of lymphoid organs
(This special issue belongs to the Section Immunology and Immunotherapy)
Molecular Diagnosis and Genomic Insights in Cancer
edited by Jingjing Hu
submission deadline 31 Jul 2026 | Viewed by 60 | Submission Open
Keywords: oncogenes; gene therapy; next-generation sequencing (NGS); targeted therapy; personalized medicine; cancer diagnosis; cancer therapy
(This special issue belongs to the Section Cancer Biology and Oncology)
Multidisciplinary Approaches in Complex Ear, Nose and Throat Pathology submission deadline 31 Jul 2026 | Viewed by 59 | Submission Open
Keywords: complex ENT pathology; head and neck cancer; cancer; personalized therapy; trauma; sleep disorders; immune ENT diseases; artificial intelligence
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances in Radiological and Optical Imaging for Clinical Oncology
edited by and
submission deadline 31 Jul 2026 | Viewed by 59 | Submission Open
Keywords: clinical oncology; medical imaging; artificial intelligence; deep learning; radiomics; image-guided therapy; treatment response; prognosis; optical imaging; precision medicine
(This special issue belongs to the Section Cancer Biology and Oncology)
Multiple Sclerosis: Neuro-Technology and New Approaches for Treatment, Diagnosis and Symptom Monitoring
edited by and Letizia Leocani
submission deadline 31 Jul 2026 | Viewed by 58 | Submission Open
Keywords: multiple sclerosis; treatment; neuromodulation; digital biomarkers; digital tools; artificial intelligence; wearable sensors; eHealth
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Advanced Molecular Diagnosis and Treatment of Biliary Cancer
edited by Jing Han Hong
submission deadline 31 Jul 2026 | Viewed by 53 | Submission Open
Keywords: biliary tract cancer; cholangiocarcinoma; epigenetics; rare cancers; molecular characterisation; precision medicine; drug development; molecular heterogeneity; precision oncology; therapy; biomarkers; diagnosis; molecular mechanisms
(This special issue belongs to the Section Cancer Biology and Oncology)
Connections Between Diabetes Mellitus, Other Metabolic and Endocrine Dysfunctions and Cardiovascular Pathologies—Third Edition
edited by Dragos Cozma, Cristina Tudoran and Claudiu Stoicescu
submission deadline 31 Jul 2026 | Viewed by 52 | Submission Open
Keywords: diabetes mellitus; insulin resistance; metabolic syndrome; obesity thyroid; dysfunction hormonal; alterations endothelial; dysfunction coronary; artery disease; hypertension peripheric; arterial disease
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Multidisciplinary Advances in Cancer Care—Innovations in Early Detection, Precision Medicine, and AI Driven Strategies
edited by Eva Y W Cheung, and Ellie S.M. Chu
submission deadline 31 Jul 2026 | Viewed by 51 | Submission Open
Keywords: cancer early detection; multi-cancer screening; liquid biopsy; cancer biomarkers; tumor imaging and prognostics radiomics and artificial intelligence; precision oncology; targeted therapies; immunotherapy and tumor microenvironment; cancer prevention
(This special issue belongs to the Section Cancer Biology and Oncology)
Innovative Approaches in In Vitro Models: From Design to Application
edited by
submission deadline 31 Jul 2026 | Viewed by 49 | Submission Open
Keywords: in vitro disease models; human cell isolation and characterization; organ-on-a-chip and microfluidic systems; 3D bioprinting and tissue engineering; translational biomedical research
(This special issue belongs to the Section Biomedical Engineering and Materials)
Natural Products in Cancer Research: From Traditional Medicine to Modern Drugs
edited by Chih-Jui Chang and
submission deadline 31 Jul 2026 | Viewed by 48 | Submission Open
Keywords: natural products; cancer therapy; tranditional Chinese medicine (TCM); pharmacology; precision oncology; tanslational research
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
The Development of Cancer Immunotherapy (2nd Edition)
edited by
submission deadline 31 Jul 2026 | Viewed by 48 | Submission Open
Keywords: cancer immunotherapy; immune checkpoint inhibitors; genetically modified T-cell therapy; hematological cancers; solid tumors
(This special issue belongs to the Section Cancer Biology and Oncology)
Acute and Chronic Heart Failure: Pathophysiology and New Therapeutic Developments, 3rd Edition
edited by and Valentina Mercurio
submission deadline 31 Jul 2026 | Viewed by 47 | Submission Open
Keywords: heart failure with reduced ejection fraction; heart failure with preserved ejection fraction; pathophysiological novelties; treatment advances; pulmonary arterial hypertension; at-home follow-up of patients with heart failure
(This special issue belongs to the Section Molecular and Translational Medicine)
The Role of Immunity and Inflammation in Cardiovascular Diseases submission deadline 31 Jul 2026 | Viewed by 46 | Submission Open
Keywords: cardiovascular diseases; immunity; inflammation; atherosclerosis; vascular remodeling; biomarkers; microbiome; immunomodulation; targeted therapies
(This special issue belongs to the Section Immunology and Immunotherapy)
Precision Microbiome Modulation for Metabolic and Inflammatory Diseases
edited by
submission deadline 31 Jul 2026 | Viewed by 43 | Submission Open
Keywords: gut microbiome; systemic inflammation; insulin resistance; non-alcoholic fatty liver disease (NAFLD); neuroinflammation; metabolic syndrome
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Modern Approaches to Breast Cancer Biology and Therapy
edited by Zofia Łapińska and Anna Szewczyk
submission deadline 31 Jul 2026 | Viewed by 43 | Submission Open
Keywords: breast cancer; molecular pathology; hormonal therapy; estrogen receptor signaling; targeted therapies; immunotherapy; electric pulse-based therapies; precision oncology; biomarkers (ER/PR/HER2); multigene testing; combination therapies; therapeutic resistance; novel treatment strategies
(This special issue belongs to the Section Cancer Biology and Oncology)
State of the Art on Demyelinating Diseases in Latin America
edited by and Liliana Patrucco
submission deadline 31 Jul 2026 | Viewed by 43 | Submission Open
Keywords: demyelinating disorders; multiple sclerosis; neuromyelitis optica spectrum disorder; MOG antibody-associated disease; IgG-Aquarin-4 antibody; anti-MOG antibody; acute disseminated encephalomyeloitis; MRI; cerebrospinal fluid; steroids; disease modifying therapies
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Bridging Advanced Research and Clinical Applications: AI and Molecular Insights in Gynecologic Oncology submission deadline 31 Jul 2026 | Viewed by 42 | Submission Open
Keywords: gynecologic cancer biomarkers; AI-driven molecular analysis; machine learning models; ovarian cancer gene signatures; endometrial cancer profiling; cervical cancer prediction; multi-omics integration; prognostic and predictive algorithms; precision gynecologic oncology; translational bioinformatics
(This special issue belongs to the Section Cancer Biology and Oncology)
Glaucoma: The Mechanisms and Novel Therapeutic Approaches
edited by Samantha Sze Wan Shan
submission deadline 31 Jul 2026 | Viewed by 41 | Submission Open
Keywords: intraocular pressure; ocular hypertension; outflow facility; gene-editing; epigenetic modifications; small RNAs; translational studies; biomarkers
(This special issue belongs to the Section Molecular and Translational Medicine)
State-of-the-Art Cancer Biology, Biodiagnostics and Therapeutics in Japan—Second Edition
edited by , and Hideshi Ishii
submission deadline 31 Jul 2026 | Viewed by 41 | Submission Open
Keywords: cancer biology; epigenetics; early detection; diagnosis; biodiagnosis; novel therapeutics; new paradigms
(This special issue belongs to the Section Cancer Biology and Oncology)
Clinical Genetics and Genomics of Neurodegenerative Diseases
edited by and
submission deadline 31 Jul 2026 | Viewed by 40 | Submission Open
Keywords: dementia; neurodegeneration; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; ALS; genetics; genomics; translational medicine; frontotemporal dementia; LATE; prion disease; neurocognitive impairment; GWAS; polygenic risk
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Advances in Heart Failure Pharmacotherapy submission deadline 31 Jul 2026 | Viewed by 39 | Submission Open
Keywords: heart failure; pharmacotherapy; precision medicine; pharmacogenomics; pharmacokinetics; pharmacodynamics
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Advances in Infectious and Inflammatory Diseases
edited by
submission deadline 31 Jul 2026 | Viewed by 35 | Submission Open
Keywords: infectious diseases; inflammatory pathology; systemic and organ-specific pathology; diagnostic and comparative pathology; histopathology and tissue-based diagnosis; molecular and immunohistochemical diagnostics; host– pathogen interactions; emerging and re-emerging pathogens; clinical– pathological correlations
(This special issue belongs to the Section Molecular and Translational Medicine)
Macrophages and Immune Modulation in Cancer Therapy
edited by
submission deadline 31 Jul 2026 | Viewed by 35 | Submission Open
Keywords: tumor-associated macrophages; macrophage plasticity; macrophage reprogramming; immune modulation; macrophage-targeted therapies; macrophage– stromal interactions
(This special issue belongs to the Section Cancer Biology and Oncology)
Bioinformatics Analysis of RNA for Human Health and Disease—2nd Edition
edited by
submission deadline 31 Jul 2026 | Viewed by 33 | Submission Open
Keywords: bioinformatics; computational biology; machine learning; multi-omics data analysis; biomarker detection; biomedical AI convergence; medical and public health informatics; RNA sequencing (RNA-Seq); functional genomics; RNA-protein interactions; experimental validation of biomarkers; RNA structural biology; transcriptome-wide association studies (TWAS); gene expression profiling; RNA modifications (e.g.; m6A; pseudouridylation); in vitro and in vivo RNA functional studies; single-cell RNA analysis; RNA therapeutics development
(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)
New Insights into Bone and Cartilage Biology (2nd Edition)
edited by Vincent Yuan
submission deadline 31 Jul 2026 | Viewed by 32 | Submission Open
Keywords: bone remodeling; cartilage degeneration; osteoporosis osteoarthritis; mitochondrial function; protein modifications; immune signaling; therapeutic strategies
(This special issue belongs to the Section Molecular and Translational Medicine)
Osteoblast Differentiation in Skeletal Disease States
edited by and
submission deadline 31 Jul 2026 | Viewed by 32 | Submission Open
Keywords: osteoblast differentiation; bone remodeling; skeletal diseases; inflammation and bone metabolism; cellular stress pathways; mesenchymal stem cells
(This special issue belongs to the Section Cell Biology and Pathology)
New Diagnostic and Therapeutic Approaches in Diabetic Microvascular Complications, 3rd Edition submission deadline 31 Jul 2026 | Viewed by 31 | Submission Open
Keywords: diabetic retinopathy; diabetic foot ulcer; inflammatory biomarkers; microbiota; novel therapies
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Epigenetic Regulation and Its Impact for Medicine (3rd Edition)
edited by
submission deadline 31 Jul 2026 | Viewed by 31 | Submission Open
Keywords: gene expression; DNA methylation; histone modifications; non-coding RNAs; biomarkers
(This special issue belongs to the Section Molecular and Translational Medicine)
Mechanism and Clinical Perspective: Pathogens of Infectious Respiratory Diseases
edited by
submission deadline 31 Jul 2026 | Viewed by 30 | Submission Open
Keywords: pathogenesis; respiratory diseases; sepsis; mechanism; clinical perspectives; host– pathogen interactions
(This special issue belongs to the Section Immunology and Immunotherapy)
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