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Biomedicines
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State-of-the-Art Neurobiology and Clinical Neuroscience in the United States
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State-of-the-Art Neurobiology and Clinical Neuroscience in the United States

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 463

Special Issue Editors

Dr. Justin Miller

E-Mail Website
Guest Editor
1. Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY 40536, USA
2. Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA
3. Division of Biomedical Informatics, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA
4. Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA
Interests: genetics; Alzheimer’s disease; neuroscience
Special Issues, Collections and Topics in MDPI journals
Dr. Laura Ibanez

E-Mail Website
Guest Editor
1. Department of Psychiatry, Washington University in Saint Louis School of Medicine, 4444 Forest Park, Campus Box 8134, Saint Louis, MO 63110, USA
2. NeuroGenomics and Informatics Center, Washington University in Saint Louis School of Medicine, Saint Louis, MO 63110, USA
3. Department of Neurology, Washington University in Saint Louis School of Medicine, Saint Louis, MO 63110, USA
Interests: neurodegeneration; biomarkers; Alzheimer’s disease; Parkinson’s disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advances in neurobiology and clinical neuroscience show population-specific differences in neuropathology and genetic risk for various neurodegenerative diseases. This Special Issue is part of a series of Special Issues specific to different regions of the world and is intended to help researchers better understand the current state of clinical neuroscience in their region, in this case the United States. Areas of special interest include, but are not limited to, the following:

  1. General neurobiology;
  2. Advances in classifying specific neurodegenerative diseases;
  3. Novel techniques for measuring changes in neurobiology;
  4. Clinical applications of neuroscience;
  5. Interesting case studies;
  6. Advances in artificial intelligence and machine learning related to neurobiology or neuroscience;
  7. Comparative studies of neurobiology between the United States and other regions.

We invite you to reach out to Drs. Justin Miller and Laura Ibanez if you have any questions related to this Special Issue.

Dr. Justin Miller
Dr. Laura Ibanez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurobiology
  • neuroscience
  • bioinformatics
  • Alzheimer’s disease
  • Parkinson’s disease
  • imaging
  • neurotransmitters
  • neurodegeneration
  • clinical
  • population genetics

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Published Papers (1 paper)

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Research

16 pages, 2097 KB  
Article
Amnestic Mild Cognitive Impairment Does Not Alter Cerebrocortical Oxygenation Dynamics During Acute Hypoxia–Reoxygenation in Older Adults
by Christopher Cortez, Jewelia Rattanavong, Hannah Dyson, Sarah Ross, Robert T. Mallet and Xiangrong Shi
Biomedicines 2025, 13(11), 2661; https://doi.org/10.3390/biomedicines13112661 - 30 Oct 2025
Abstract
Background: This study examined the impact of amnestic mild cognitive impairment (aMCI) on dynamic changes in cerebrocortical oxygen saturation (ScO2) and O2 extraction during acute, moderately intense, normobaric hypoxia and reoxygenation in elderly adults (71 ± 6 years old). Methods: [...] Read more.
Background: This study examined the impact of amnestic mild cognitive impairment (aMCI) on dynamic changes in cerebrocortical oxygen saturation (ScO2) and O2 extraction during acute, moderately intense, normobaric hypoxia and reoxygenation in elderly adults (71 ± 6 years old). Methods: Thirty-two aMCI and thirty-five control subjects participated. Inspired and expired fractions of O2 and CO2 (mass spectrometry), arterial O2 saturation (SaO2) and prefrontal ScO2 (near-infrared spectroscopy), heart rate, tidal volume and breathing frequency were monitored while subjects breathed hypoxic air (fractional inspired O2 0.10) for 3–5 min (aMCI: 4.5 ± 0.7 min; control: 4.5 ± 0.6 min) and recovered on room air. Values at the pre-hypoxia baseline, the first and last min of hypoxia and the first min of recovery were compared within and between groups using two-factor ANOVA. Results: Despite a similar baseline SaO2 in aMCI (97.2 ± 1.6%) and control (97.3 ± 1.3%) subjects, prefrontal ScO2 was lower (p < 0.05) in the aMCI subjects in both the left (67.0 ± 1.7% vs. 69.6 ± 4.5%) and right (66.8 ± 4.6% vs. 69.4 ± 4.1%) hemispheres. Hypoxia similarly decreased SaO2 and ScO2 in both groups (last min hypoxia, aMCI vs. control subjects: SaO2 76.6 ± 5.3% vs. 77.4 ± 6.1%, left prefrontal ScO2 54.0 ± 4.9% vs. 55.2 ± 6.4%, right prefrontal ScO2 56.0 ± 4.3% vs. 58.2 ± 4.4%). Upon the resumption of room-air breathing, ScO2 recovered at similar rates in aMCI and control subjects. Conclusions: Although it produced a greater deoxygenation in the left vs. the right prefrontal cortex, acute, normobaric, moderate hypoxia was well tolerated by elderly adults, even those with aMCI. Dynamic changes in cerebral oxygenation during hypoxia and recovery were unaltered by aMCI. Brief, moderate hypoxia does not impose more intense cerebrocortical oxygen depletion in elderly adults with aMCI, despite pre-hypoxic cerebrocortical oxygenation below that of their non-MCI counterparts. Full article
(This article belongs to the Special Issue State-of-the-Art Neurobiology and Clinical Neuroscience in the United States)
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