Cellular Senescence in Age-Related Diseases: Pathophysiology and Therapeutic Approaches

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 305

Special Issue Editor


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Guest Editor
Stritch School of Medicine, Core Microscopy Facility and Department of Microbiology and Immunology, Loyola University Chicago, Chicago, IL USA
Interests: neurodegenerative disease; addiction; microscopy; senescence; therapeutics
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Special Issue Information

Dear Colleagues,

Cellular senescence, discovered in the 1960s, is a homeostatic response triggered by aging-associated insults, such as genomic instability and telomere attrition. It is characterized by a stable cell cycle arrest, which prevents the proliferation of damaged cells, and profound phenotypic changes, such as the production of a complex mixture of biologically active secreted factors, referred to as the senescence-associated secretory phenotype (SASP). As cellular senescence, a central hallmark of aging, plays an important role in age-related diseases including diabetes, cardiovascular disease, cancer, and neurodegenerative diseases, interventions targeting senescence are potential therapies for these diseases. The finding of an increased life span in murine models after the removal of senescent cells underscored the utility of targeting senescence for therapeutic benefits. Several therapeutic approaches have been developed. These include the development of drugs that selectively eliminate senescent cells,  known as senolytics, the development of drugs that modulate the SASP, known as senomorphics, and the development of drugs that revert senescence to allow senescent cells to enter the cell cycle, known as senoreverters. This Special Issue welcomes articles that clarify the molecular and physiological properties of senescent cells, shed light on the role of cellular senescence in the pathophysiology of age-related diseases, or describe the development of novel therapeutic approaches targeting cellular senescence.

Dr. David J. Rademacher
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cellular senescence
  • senescence-associated secretory phenotype
  • aging
  • senolytics
  • senomorphics
  • senoreverters
  • therapeutics

Published Papers

This special issue is now open for submission.
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