Mechanism of Mesenchymal Stromal Cells and Their Derivatives in Regenerative Medicine
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 3
Special Issue Editors
Interests: extracellular vesicles; cartilage repair; tissue engineering and regenerative medicine; stem cell and cell therapy; biomaterials; stem cell biology; wound healing
Special Issue Information
Dear Colleagues,
Mesenchymal stromal cells (MSCs) and their derivatives have garnered considerable attention for their therapeutic potential in regenerative medicine. Beyond their multipotent differentiation capacity, MSCs exhibit profound immunomodulatory, anti-inflammatory, and trophic effects that contribute to tissue repair and regeneration. Increasing evidence is highlighting the significance of MSC-derived extracellular vesicles (EVs), including exosomes and microvesicles, as key mediators of these effects, offering a cell-free alternative with reduced safety concerns and logistical barriers. Despite promising preclinical and early clinical outcomes, the precise mechanisms by which MSCs and their derivatives exert therapeutic actions remain incompletely understood. This Special Issue will explore the cellular and molecular underpinnings of MSC-based therapies, encompassing paracrine signalling pathways, immunomodulation, homing and engraftment behaviours, and the bioactive cargo carried by EVs. By shedding light on these mechanisms, we will bridge current knowledge gaps, optimise therapeutic strategies, and enhance the translation of MSC-based approaches into clinical applications. We welcome original research articles, reviews, and perspectives that provide mechanistic insights or novel methodological approaches to studying MSCs and their derivatives in the context of tissue repair, immune regulation, and disease modulation.
Dr. Jia Xian Law
Dr. Kok Lun Pang
Guest Editors
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Keywords
- mesenchymal stromal cell
- regenerative medicine
- stem cell
- extracellular vesicle
- mechanism of action
- paracrine factor
- secretome
- tissue engineering
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