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Biomedicines
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Advances in Reproductive Medicine and Health
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Advances in Reproductive Medicine and Health

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1333

Special Issue Editors

Dr. Athanasios Zikopoulos

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Guest Editor
Third Department of Obstetrics and Gynecology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece
Interests: reproductive medicine; assisted reproduction techniques; gynecological ultrasound; infertility
Dr. Sofoklis Stavros

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Guest Editor
Third Department of Obstetrics and Gynecology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece
Interests: reproductive medicine; early pregnancy; recurrent pregnancy loss; recurrent implantation failure; gynecological ultrasound; infertility
Special Issues, Collections and Topics in MDPI journals
Dr. Anastasios Potiris

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Guest Editor
Third Department of Obstetrics and Gynecology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece
Interests: reproductive medicine; assisted reproduction techniques; recurrent pregnancy loss; recurrent implantation failure; infertility

Special Issue Information

Dear Colleagues,

Infertility is a devastating, multifactorial issue affecting 12 to 15% of reproductive-age couples. This Special Issue aims to explore recent advancements in reproductive medicine and health, focusing on innovations in assisted reproductive technologies (ART), fertility preservation, and the impact of novel laboratory investigations on reproductive outcomes. This Special Issue covers topics related to in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), preimplantation genetic testing (PGT), cryopreservation techniques, recurrent implantation failures, recurrent miscarriages, early pregnancy complications after ART, use of stem cells, gene editing, gene expression, protein and miRNA expression, and their impact on reproductive and perinatal outcomes.

The objectives of the Special Issue are as follows:

  • Latest technological and clinical developments in assisted reproductive technologies (ART);
  • Efficacy and safety of modern fertility preservation and stimulation methods;
  • From gene to protein expression: Advances related to better understanding of infertility and personalized care;
  • Ethical and policy challenges associated with reproductive medicine;
  • Future trends and experimental strategies in reproductive medicine.

Ultimately, this Special Issue seeks to explore and evaluate how these advancements improve reproductive outcomes, affect perinatal outcomes, and lead towards personalized and holistic care of infertile couples.

Dr. Athanasios Zikopoulos
Dr. Sofoklis Stavros
Dr. Anastasios Potiris
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reproductive medicine
  • assisted reproductive technology
  • fertility preservation
  • IVF
  • early pregnancy
  • miscarriages
  • proteomics
  • metabolomics
  • transcriptomics
  • infertility
  • bioethics
  • cryopreservation
  • personalized medicine

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

13 pages, 1782 KB  
Article
The Detrimental Impact of Bisphenol S (BPS) on Trophoblastic Cells and the Ishikawa Cell Lines: An In Vitro Model of Cytotoxic Effect and Molecular Interactions
by Eirini Drakaki, Despoina Mavrogianni, Anastasios Potiris, Stavroula Xydi-Chrysafi, Panagiotis Kotrotsos, Nikolaos Thomakos, Alexandros Rodolakis, Georgios Daskalakis and Ekaterini Domali
Biomedicines 2025, 13(8), 1938; https://doi.org/10.3390/biomedicines13081938 - 8 Aug 2025
Viewed by 325
Abstract
Background/Objectives: Bisphenols (BPs) and especially bisphenol S (BPS), an analog of bisphenol A (BPA), are widely used and induce oxidative stress, resulting in the inhibition of cell proliferation and induction of apoptosis which all are crucial for reproduction, the progression of pregnancy, [...] Read more.
Background/Objectives: Bisphenols (BPs) and especially bisphenol S (BPS), an analog of bisphenol A (BPA), are widely used and induce oxidative stress, resulting in the inhibition of cell proliferation and induction of apoptosis which all are crucial for reproduction, the progression of pregnancy, and fertility. The present study integrates trophoblastic cells as an in vitro model to provide evidence and investigate the molecular interactions regarding placenta-related pregnancy complications after cytotoxic exposure to BPS. Methods: Human endometrial epithelial adenocarcinoma Ishikawa cell lines and trophoblastic cells were cultured. Cells obtained from the cultures were divided into plates and incubated for 24 h with different concentrations of bisphenol S (BPS). Cell viability was measured using the Countess Automated Cell Counter and the viability of Ishikawa cells was assessed after 48 h and for trophoblasts after 24 h. The effect of siRNA on NANOG expression was evaluated using qRT-PCR. Quantification of DNMT and NANOG was performed by qPCR and the G6PD gene was used as an internal control. Results: Real-time PCR results showed that the expression of the DNMT1 gene varies depending on the concentration of BPS in trophoblastic cells. In Ishikawa cell lines, real-time PCR results showed that DNMT1 gene expression was higher due to cell increase, but the measured fold change did not differ significantly. Data analysis indicated a statistically significant difference between CpDNMT1 in trophoblasts with and without BPS, where higher values were observed in the case of BPS presence (p = 0.019). The largest difference was observed between CpDNMT1 trophoblasts without BPS and CpDNMT1 Ishikawa with BPS (p < 0.001). Silencing the NANOG gene resulted in a reduced expression of DNMT1, while the G6PD gene was still detected. Conclusions: The results of this study highlight the cytotoxic effects of BPS and consequently its effect on trophoblast viability. The results of NANOG-DNMT1 gene expression related to BPS exposure reinforces our understanding of EDC-induced placental dysfunction. Full article
(This article belongs to the Special Issue Advances in Reproductive Medicine and Health)
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