Recent Therapeutic Advances in Parkinson’s Disease

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 975

Special Issue Editor


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Guest Editor
Department of Neurology, Changhua Christian Hospital, Changhua 50006, Taiwan
Interests: Parkinson’s disease; tremor; dystonia; chorea; ataxia; mitochondria disease; big data analytics; machine learning

Special Issue Information

Dear Colleagues,

Parkinson's disease (PD) is a progressive neurological disorder associated with a number of motor, cognitive and psychomotor symptoms. Medication is primarily used as the current treatment to modify neurotransmitters and treat symptoms. The gold standard for PD treatment is dopamine replacement therapy with levodopa. Nevertheless, the treatment for PD is aimed at improving symptoms and cannot slow the progression of the disease. New laboratory medicine research, translation medicinal research, and preclinical studies are providing new directions for treating this disease. The understanding of the mechanism of PD and the development of treatments that influence the fundamental pathology of the condition are advancing.

This Special Issue aims to assemble high-quality original articles and reviews on the current treatments and recent therapeutic developments in PD and related disorders.

Dr. Chieh-Sen Chuang
Guest Editor

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Keywords

  • Parkinson's disease
  • disease-modifying therapy
  • continuous dopaminergic stimulation
  • non-dopaminergic drugs
  • deep brain stimulation
  • drug repurposing
  • immunotherapies
  • gene therapies

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Published Papers (1 paper)

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Research

11 pages, 677 KiB  
Communication
Inefficacy of Repetitive Transcranial Magnetic Stimulation in Parkinson’s Disease Patients with Levodopa-Induced Dyskinesias: Results from a Pilot Study
by Alma Medrano-Hernández, Gabriel Neri-Nani, Mayela Rodríguez-Violante, René Drucker-Colín and Anahí Chavarría
Biomedicines 2025, 13(7), 1663; https://doi.org/10.3390/biomedicines13071663 - 8 Jul 2025
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Abstract
Background: Parkinson’s disease (PD) presents a significant challenge due to its wide range of motor, non-motor, and treatment-related symptoms. Non-invasive interventions like transcranial magnetic stimulation (TMS) are being explored for potential therapeutic benefits. This study aimed to assess if a high-frequency repetitive TMS [...] Read more.
Background: Parkinson’s disease (PD) presents a significant challenge due to its wide range of motor, non-motor, and treatment-related symptoms. Non-invasive interventions like transcranial magnetic stimulation (TMS) are being explored for potential therapeutic benefits. This study aimed to assess if a high-frequency repetitive TMS protocol (HF-rTMS) consisting of 10 trains of 100 pulses of rTMS at 25 Hz over the motor cortex (M1) at 80% of the resting motor threshold could be effective in treating motor or non-motor symptoms in patients with PD with levodopa-induced dyskinesias. Methods: A randomized, single-blinded, placebo-controlled pilot trial was conducted with eleven PD patients. Nine patients received HF-rTMS, while two received sham stimulation. Patients were exhaustively evaluated using validated clinical scales to assess motor and non-motor symptoms. The study followed a rigorous protocol to avoid bias, with assessments conducted by a neurologist specialized in single-blinded movement disorder. Results: The HF-rTMS group experienced a statistically significant slight worsening in both motor and non-motor symptoms, particularly in the mood/cognition and gastrointestinal domains. However, positive effects were observed in some non-motor symptoms, specifically reduced excessive sweating and weight. No adverse effects were reported. Conclusions: Although HF-rTMS did not produce significant motor improvements, its potential benefit on specific non-motor symptoms, such as autonomic regulation, warrants further investigation. Full article
(This article belongs to the Special Issue Recent Therapeutic Advances in Parkinson’s Disease)
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