New Challenges in the Study of Liver Diseases: From Molecular Pathogenesis to Therapeutic Approaches—4th Edition
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 160
Special Issue Editor
Interests: liver diseases; genetics; metabolism; molecular biology; NAFLD; NASH; insulin resistance; genetics; biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The liver plays an essential role in all metabolic processes, acting as a hub that integrates hormone and nutrient stimuli, as well as catabolic responses. It has a peculiar structure and anatomical localization that possess the ability to network with the entire digestive system. Alterations in hepatic homeostasis are particularly harmful; hence, the increasing number of patients affected represents a global concern.
The term liver diseases embraces an umbrella of hepatic disorders, including viral and toxic hepatitis, inherited and acquired cholestatic injuries, non-alcoholic fatty liver disease (NAFLD), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). These disorders are usually complex in their molecular pathogenesis, and multiple risk factors may intervene in these processes. Among them, genetics and epigenetic factors have a primary impact on their development. Likewise, liver disorders are usually related to extrahepatic comorbidities, such as cardiovascular and intestinal complications. Since the gold standard for their diagnosis is still invasive and no therapeutic consensus exists for their management, this Special Issue aims to focus on new horizons in the discovery of noninvasive biomarkers and novel perspectives in the definition of the precise molecular mechanisms that precipitate liver damage towards end-stage conditions.
Dr. Marica Meroni
Guest Editor
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Keywords
- liver diseases and related pathologies
- non-alcoholic fatty liver diseases (NAFLDs)
- obesity
- type 2 diabetes
- cardiovascular diseases
- gut–liver axis
- viral hepatitis
- alcoholic liver diseases (ALDs)
- cholestatic disorders
- personalized medicine
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