The Role of Telomere and Telomerase in Human Disease-2nd Edition
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 6
Special Issue Editor
2. Sackler School of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel
3. Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petah Tikva 49100, Israel
Interests: telomeres; telomerase; cancer research; exosomes; microenvironment
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Telomeres and telomerase are receiving ever-increasing interest from the scientific community. The telomere/telomerase complex is the key element that determines unlimited replicative potential. Telomere shortening occurs at each round of cell division and, accompanied by DNA synthesis, restricts cell proliferation and induces cell senescence and apoptosis in checkpoint-proficient normal somatic cells. Telomerase is a reverse transcriptase that maintains the length of the telomere, endowing cells with the ability to proliferate indefinitely. Thus, the telomere/telomerase interaction plays a key role in the initiation and progression of diseases such as cancer and aging, making this complex an attractive therapeutic target.
This Special Issue welcomes original studies and review articles presenting novel findings at the basic and translational levels of research in this field. Specifically, we are interested in the following issues: 1. the roles of shelterin and other proteins in telomere lengths regulation; 2. telomerase as an anticancer drug target; 3. extracurricular activities of telomerase; and 4. the role of telomerase in various diseases.
Dr. Orit Uziel
Guest Editor
Manuscript Submission Information
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Keywords
- telomere
- telomerase
- cancer
- aging
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Related Special Issue
- The Role of Telomere and Telomerase in Human Disease in Biomedicines (5 articles)
