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Biomedicines
Special Issues
SARS-CoV-2 Infection: Focus on Pathophysiological Characteristics, Complications and Effects of...
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SARS-CoV-2 Infection: Focus on Pathophysiological Characteristics, Complications and Effects of Vaccinations

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Microbiology in Human Health and Disease".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 16802

Special Issue Editors

Dr. Barbara Brogna

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Guest Editor
Unit Interventional and Emergency Radiology, AORN, San Giuseppe Moscati Hospital, Contrada Amoretta, 83100 Avellino, Italy
Interests: chest imaging; COVID-19; gastrointestinal imaging; emergency
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Marina Piscopo

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Guest Editor
Department of Biology, University of Naples Federico II, 80138 Napoli, NA, Italy
Interests: histones; sperm proteins; environmental pollution; heavy metals; reproductive health; sperm chromatin; epigenetic modifications; marine organisms; human spermatogenesis
Special Issues, Collections and Topics in MDPI journals
Dr. Carlo Brogna

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Guest Editor
Department of Research, Craniomed Group Facility Srl., 20091 Bresso, Italy
Interests: acetylcholine; bacteriophage; toxin; viruses; coronavirus; bacteria

Special Issue Information

Dear Colleagues,

This Special Issue aims to include high-quality works on both the pathophysiological characteristics and complications of SARS-CoV-2 infections during the different phases of the pandemic, with particular emphasis on pandemic risk assessment, the role of predictive and prognostic biomarkers, if there is a link between autoimmunity and long COVID, the role of the gut and lung microbiome, and the role of imaging and artificial intelligence.

Dr. Barbara Brogna
Prof. Dr. Marina Piscopo
Dr. Carlo Brogna
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • SARS-CoV-2 complications
  • SARS-CoV2 prognostic and predictive biomarkers
  • long COVID-19 and autoimmune disease
  • COVID-19 and microbiome
  • artificial intelligence

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Published Papers (1 paper)

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Research

19 pages, 852 KiB  
Article
Autoantibodies Targeting G-Protein-Coupled Receptors and RAS-Related Molecules in Post-Acute COVID Vaccination Syndrome: A Retrospective Case Series Study
by Mauro Mantovani, Paolo Bellavite, Serafino Fazio, Giuseppe Di Fede, Marco Tomasi, Daniele Belli and Elisabetta Zanolin
Biomedicines 2024, 12(12), 2852; https://doi.org/10.3390/biomedicines12122852 - 15 Dec 2024
Viewed by 16375
Abstract
Background/Objectives: While post-acute COVID-19 syndrome is well known and extensively studied, the post-acute COVID vaccination syndrome (PACVS) is a more recent nosological entity that is poorly defined at the immunopathological level, although it shares many symptoms with the sequelae of viral infections. [...] Read more.
Background/Objectives: While post-acute COVID-19 syndrome is well known and extensively studied, the post-acute COVID vaccination syndrome (PACVS) is a more recent nosological entity that is poorly defined at the immunopathological level, although it shares many symptoms with the sequelae of viral infections. Methods: This single-center retrospective study reports a case series of 17 subjects vaccinated with mRNA or adenoviral vector vaccines who were healthy before vaccination and had never been infected with SARS-CoV-2 but who presented with symptoms similar to PACVS for a median time of 20 months (min 4, max 32). The medical records of all patients referred to our outpatient clinic over a one-year period were retrospectively analyzed. Results: In this group, serological tests showed that, in addition to positivity for anti-spike protein antibodies, a high percentage of subjects were positive for antibodies against G protein-coupled receptors and molecules involved in the response to SARS-CoV-2. In a panel of 16 autoantibodies tested, a few were positively associated with some of the symptoms reported by patients: anti-ATR1 with lymphadenopathy and/or tonsillitis; anti-ACE2 with skin symptoms such as ecchymosis, skin oedema, and rash; anti-MAS1 with widespread burning sensation; and anti-STAB1 with skin oedema and rash. Anti-ADRA2A were negatively associated with memory loss and/or mental fog. ACE2 correlated with the serum levels of anti-S antibodies, supporting the hypothesis of an anti-idiotype mechanism in the immunopathogenesis of PACVS. Conclusions: This exploratory analysis suggests that the levels of autoantibodies directed against ACE2, and probably also MAS1 and STAB1, may serve as biomarkers for PACVS. Full article
(This article belongs to the Special Issue SARS-CoV-2 Infection: Focus on Pathophysiological Characteristics, Complications and Effects of Vaccinations)
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