HIV Therapy: The Latest Developments in Antiviral Drugs

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1136

Special Issue Editor


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Guest Editor
Infectious Diseases Unit, Hospital Universitario Son Espases, Palma de Mallorca, Spain
Interests: HIV; infectious diseases; COPD

Special Issue Information

Dear Colleagues,

This Special Issue, "HIV Therapy: The Latest Developments in Antiviral Drugs", aims to collate cutting-edge experimental and laboratory research on HIV treatments. Despite significant advancements in antiretroviral therapy (ART), challenges such as drug resistance, long-term toxicity, and the quest for a functional cure or eradication necessitate continuous innovation.

We invite contributions that delve into novel antiviral agents, including small molecules and biologics; their mechanisms of action; and innovative therapeutic strategies. Emphasis will be placed on preclinical studies, in vitro and ex vivo models, the virological and immunological mechanisms underlying new therapies, novel drug delivery systems explored at the laboratory level, and approaches to understanding and targeting HIV reservoirs.

This Special Issue will highlight basic and translational research that underpins the development of next-generation HIV therapies, focusing on the molecular, cellular, and immunological insights that will pave the way for future clinical applications. We welcome original research articles and comprehensive reviews that fit within this experimental medicine framework.

Dr. Francisco Javier Fanjul Losa
Guest Editor

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Keywords

  • HIV
  • antiviral drugs
  • experimental therapeutics
  • drug discovery
  • viral reservoirs
  • mechanism of action
  • preclinical models
  • novel HIV targets
  • antiretroviral therapy (ART)
  • immunotherapy (experimental aspects)

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Published Papers (1 paper)

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Review

11 pages, 604 KB  
Review
HIV Therapy: The Latest Developments in Antiviral Drugs—A Scoping Review
by Francisco Fanjul, Meritxell Gavalda, Antoni Campins, Adria Ferré, Luisa Martín, María Peñaranda, Mari Ángeles Ribas, Elena Pastor-Ramon, Sophia Pinecki and Melchor Riera
Biomedicines 2025, 13(11), 2629; https://doi.org/10.3390/biomedicines13112629 - 27 Oct 2025
Viewed by 953
Abstract
Background: Major advances in antiretroviral therapy (ART) have transformed HIV into a chronic condition, yet drug resistance, long-term toxicities, adherence challenges, and persistent viral reservoirs continue to drive innovation. Objectives: To map and synthesize recent developments in anti-HIV drugs and delivery platforms with [...] Read more.
Background: Major advances in antiretroviral therapy (ART) have transformed HIV into a chronic condition, yet drug resistance, long-term toxicities, adherence challenges, and persistent viral reservoirs continue to drive innovation. Objectives: To map and synthesize recent developments in anti-HIV drugs and delivery platforms with a focus on (i) new molecules in clinical development and (ii) novel mechanisms of action, following a scoping review framework aligned with PRISMA-ScR. Sources: We interrogated PubMed, Embase.com, Web of Science, and Scopus (January 2020–September 2025) and screened abstracts from CROI, IAS/AIDS, IDWeek, and HIV Glasgow (2023–2025). Content: The evidence base underscores capsid inhibition (lenacapavir) for multidrug-resistant HIV and its expansion into prevention, long-acting intramuscular maintenance with cabotegravir/rilpivirine, maturation inhibitors (zabofiravir), and attachment inhibition with fostemsavir. Broadly neutralizing antibodies (bNAbs) can sustain ART-free suppression in selected individuals. Ultra-long-acting delivery systems are advancing toward translational evaluation. Summary: The pipeline is diversifying toward less frequent dosing, new targets, and combination strategies. Successful and ethical implementation will require resistance-informed selection, equitable access, and reimagined healthcare delivery models that accommodate long-acting technologies. Full article
(This article belongs to the Special Issue HIV Therapy: The Latest Developments in Antiviral Drugs)
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