Advances in Heart–Brain Axis
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 26
Special Issue Editor
Interests: synaptic plasticity; NMDAreceptor; autism; endothelial cell; neurovascular coupling; Ca2+ signaling; nitric oxide
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The intimate and dynamic communication between the heart and brain has emerged as a crucial area of investigation in neuroscience and cardiovascular medicine. Once considered as functionally distinct organs, the heart and brain are now recognized as part of an integrated bidirectional axis, interconnected through complex neural, humoral, metabolic, and immune pathways. Disruptions in this dialogue have been implicated in a wide range of disorders, including heart failure, arrhythmias, stroke, depression, and cognitive decline. Mounting evidence demonstrates that alterations in cardiac function can profoundly affect brain structure and activity, while central nervous system dysfunction—including stress, autonomic imbalance, and neuroinflammation—can negatively impact cardiac output and rhythm stability.
This Special Issue aims to explore the multifaceted mechanisms that govern heart–brain crosstalk in both physiological and pathological conditions. Topics of interest include neurocardiology, autonomic regulation, the role of neuroinflammation, cardiac–cerebral syndromes, psychocardiology, and emerging molecular and imaging biomarkers. We are particularly interested in translational approaches that bridge basic science and clinical practice and in innovative therapeutic perspectives targeting this axis.
I am, therefore, pleased to invite all of you to contribute to this Special Issue, “Advances in Heart–Brain Axis”, by submitting your most recent research or theoretical perspectives on the mechanisms linking cardiovascular and central nervous system function. Particular emphasis will be given to the role of calcium signaling, synaptic plasticity, and ion transport in mediating heart–brain interactions under both physiological and pathological conditions. Experimental studies, comprehensive reviews, and insightful commentaries are all warmly welcome.
Dr. Teresa Soda
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- heart–brain axis
- neurocardiology
- autonomic nervous system
- neuroinflammation
- cardiac–cerebral syndromes
- psychocardiology
- calcium signaling
- synaptic plasticity
- ion transport
- translational neuroscience
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