Glomerular Disease and Cystic Kidney Disease: From Pathogenesis to Novel Therapeutic Approaches—2nd Edition
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 1262
Special Issue Editors
Interests: polycystic kidney disease; glomerular disease; kidney transplantation; immunology
Special Issues, Collections and Topics in MDPI journals
Interests: Glomerular disease, kidney transplantation; acute kidney injury
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue aims to gather publications related to both primary and secondary glomerular disease, as well as cystic kidney disease, especially polycystic kidney disease, which is the most common hereditary kidney disease. Glomerular disease describes a variety of relatively rare immune-mediated diseases characterized by damage to the glomerular compartment of the kidney. If not properly treated, glomerular disease can lead to chronic kidney disease and irreversible kidney failure. On the other hand, cystic kidney disease represents multisystemic disorders that can develop due to genetic or non-genetic causes in children and adults and may have serious renal and extrarenal complications. Both of these entities have shown notable progress in their complex pathophysiology, and various potential therapeutic targets are available for which novel treatments are being developed or repurposed. The growing awareness of the immunopathogenesis of glomerular diseases and the improvements in immune phenotyping for the classification of patients have facilitated the choice of targeted immunotherapies. Regarding polycystic kidney disease, tolvaptan, a selective vasopressin V2 antagonist, has been proven to attenuate disease progression, and several other disease-modifying therapies are currently being investigated in clinical trials. Furthermore, extended genetic testing, with next-generation sequencing, is another evolving diagnostic tool to ultimately define a molecular diagnosis and appears extremely useful in both of these entities.
This Special Issue welcomes original articles and reviews focused on the pathogenesis and treatment of glomerular diseases and cystic kidney diseases.
Dr. Vassilis Filiopoulos
Dr. Chrysanthi Skalioti
Guest Editors
Manuscript Submission Information
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Keywords
- glomerular disease
- glomerulonephritis
- glomerulopathy
- podocytopathies
- ciliopathies
- cystic kidney disease
- polycystic kidney disease
- tolvaptan
- vasopressin
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