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Biomedicines
Special Issues
Antioxidant Materials with Additional Biological Properties
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Antioxidant Materials with Additional Biological Properties

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 2035

Special Issue Editor

Dr. Nurettin Sahiner

E-Mail Website
Guest Editor
1. Department of Bioengineering, U.A. Whitaker College of Engineering, Florida Gulf Coast University, 10501 FGCU Boulevard South, Fort Myers, FL 33965, USA
2. Department of Chemistry, Faculty of Sciences, Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey
Interests: natural polymers; glycosaminoglycans; sugar alcohols; carbohydrates; polyphenolics; amino acids; peptides; nano/microparticles; antioxidant; anti-inflammatory; antimicrobial activity; ROS-scavenging effect; antiviral; antifungal; biocidal; anticancer; controlled release; drug delivery; biocompatible; blood compatible; surface; (bio)interfaces; smart surfaces; surface modification; superhydrophobic; super hydrophilic; (bio)sensor; theragnostic, biopolymeric MRI agents; injectables biopolymeric materials; hydrogel; cryogel; microgel; nanogels; super porous materials; pharmacology; wound healing; wound dressing; medical device; tissue engineering; stimuli-responsive structures; wearables; artificial skin; shape memory polymers; injectable materials; biodegradable active agent carriers; carbon particle; quantum dots, carbon dots, graphene dots, g-C3N4; lubricant, intra-articular and joints injection materials; cosmetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue will mainly focus on antioxidant materials with additional and improved biological properties. In addition to natural antioxidant compounds such as natural polyphenolics and flavonoids, the use of other compounds and structures such as amino acids, peptides, natural and synthetic polymers, enzymes, vitamins, carotenoids, carbon quantum dots, drugs, phthalocyanines, dyes, minerals, clays, metal nanoparticles, and metal ions with antioxidant properties is welcome. The improved biological properties can overcome certain barriers, such as protection from infections, enabling targetability, creating immune barriers, protection from harsh biological environments, shielding from enzymatic activity and radical attacks, and so on. The use of antioxidant materials in the innovative application of biomaterials utilizing stimuli-responsive materials, hydrogels, polymeric particles, micro/nanogels, films, fibers, discs, bio-adhesives, artificial organs, composites, etc., is welcome. Also, the combination of these materials or their modified forms to attain additional biological properties such as improved biocompatibility, blood compatibility, antibacterial, antifungal, antiviral, anti-cancer properties, enzyme inhibition ability, trigger release of certain molecules, and so on that afford and enhance bio-beneficial properties effectively are suitable for this specific Special Issue, not just for bioengineering applications but also for device and sensor applications. Additionally, the use of these materials in health-related practices involving the diagnosis, prevention, and treatment of diseases and infections is welcome. Furthermore, papers related to the use of antioxidant materials with improved biological functions in scaffolds for tissue engineering, regenerative medicine, drug delivery, 3D biomaterial fabrication to modify biological processes, and so on are welcome. Finally, the use of antioxidant materials with improved biological function may be useful in the modification of drugs, proteins, metabolites, vaccines, and/or nucleic acids and in drug delivery vehicles with a focus on enhanced biological properties that can overcome the challenges encountered in transforming biomaterials into viable and useful products.

Dr. Nurettin Sahiner
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural antioxidants, flavonoids, and polyphenols
  • biocompatible and blood compatible
  • hydrogel, microgels, nanogel, and particles
  • polymeric particles, carbon quantum dots, and g-C3N4
  • stimuli-responsive materials
  • drug delivery systems, controlled release, and targeted delivery/therapies
  • antibacterial, antifungal, antiviral, anticancer, and biocidal
  • ROS-scavenging activity
  • proteins, enzyme, peptides, and amino acids
  • activate-able materials and photodynamic therapy

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Published Papers (2 papers)

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Research

22 pages, 7554 KiB  
Article
Bioactive Carbon Dots from Clove Residue: Synthesis, Characterization, and Osteogenic Properties
by Hye-Sun Hong, Hee-Jung Park, Ji-Min Lee, Zu-Yu Chen, Tae-Woo Kim, Yong-Seok Seo, Jun-Won Kang and Young-Kwon Seo
Biomedicines 2025, 13(2), 527; https://doi.org/10.3390/biomedicines13020527 - 19 Feb 2025
Viewed by 638
Abstract
Background/Objectives: Bone regeneration using nanomaterial-based approaches shows promise for treating critical bone defects. However, developing sustainable and cost-effective therapeutic materials remains challenging. This study investigates the osteogenic potential of clove-derived carbon dots (C-CDs) for bone regeneration applications. Methods: C-CDs were synthesized [...] Read more.
Background/Objectives: Bone regeneration using nanomaterial-based approaches shows promise for treating critical bone defects. However, developing sustainable and cost-effective therapeutic materials remains challenging. This study investigates the osteogenic potential of clove-derived carbon dots (C-CDs) for bone regeneration applications. Methods: C-CDs were synthesized using a green hydrothermal method. The osteogenic potential was evaluated in human bone marrow-derived mesenchymal stem cells (hBM-MSCs) and validated using ectopic bone formation and calvarial defect models. Results: C-CDs demonstrated uniform morphology (~10 nm) with efficient cellular uptake. In vitro studies showed successful osteogenic differentiation through the upregulation of RUNX2, ALP, COL1A1, and BMP-2 mediated by Wnt/β-catenin/GSK3β and BMP signaling pathways. In vivo models have also demonstrated that C-CDs are effective in promoting bone regeneration. Conclusions: These findings establish C-CDs as promising candidates for bone regeneration therapy, offering a sustainable alternative to current treatments. While optimization is needed, their demonstrated osteogenic properties warrant further development for regenerative medicine applications. Full article
(This article belongs to the Special Issue Antioxidant Materials with Additional Biological Properties)
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15 pages, 3889 KiB  
Article
Nanoparticles for Biomedical Use Derived from Natural Biomolecules: Tannic Acid and Arginine
by Mehtap Sahiner, Selin S. Suner and Nurettin Sahiner
Biomedicines 2025, 13(1), 209; https://doi.org/10.3390/biomedicines13010209 - 16 Jan 2025
Cited by 1 | Viewed by 901
Abstract
Background/Objectives: Tannic acid (TA) is a well-known natural phenolic acid composed of ten gallic acids linked to each other with ester bonding possessing excellent antioxidant properties in addition to antimicrobial and anticancer characteristics. Arginine (ARG) is a positively charged amino acid at [...] Read more.
Background/Objectives: Tannic acid (TA) is a well-known natural phenolic acid composed of ten gallic acids linked to each other with ester bonding possessing excellent antioxidant properties in addition to antimicrobial and anticancer characteristics. Arginine (ARG) is a positively charged amino acid at physiological pH because of nitrogen-rich side chain. Method: Here, poly(tannic acid-co-arginine) (p(TA-co-ARG)) particles at three mole ratios, TA:ARG = 1:1, 1:2, and 1:3, were prepared via a Mannich condensation reaction between TA and ARG by utilizing formaldehyde as a linking agent. Results: The p(TA-co-ARG) particles in 300–1000 nm size range with smooth surfaces visualized via SEM analysis were attained. Abundant numbers of functional groups, -OH, -NH2, and -COOH stemming from TA and ARG constituent confirmed by FT-IR analysis. The isoelectric point (IEP) of the particles increased from pH 4.98 to pH 7.30 by increasing the ARG ratios in p(TA-co-ARG) particles. The antioxidant capacity of p(TA-co-ARG) particles via gallic acid (GA) and rosmarinic acid (RA) equivalents tests revealed that particles possess concentration-dependent antioxidant potency and increased by TA content. The α-glucosidase inhibition of p(TA-co-ARG) particles (2 mg/mL) 1:1 and 1:2 mole ratios revealed significant enzyme inhibition ability, e.g., 91.3 ± 3.1% and 77.6 ± 12.0%. Interestingly, p(TA-co-ARG) (1:3 ratio) possessed significant antibacterial effectiveness against Escherichia coli (ATCC 8739) and Staphylococcus aureus (ATCC 6538) bacteria. Furthermore, all p(TA-co-ARG) particles at 1000 mg/mL concentration showed >80% toxicity on L929 fibroblast cells and increased as ARG content of p(TA-co-ARG) particles is increased. Conclusions: p(TA-co-ARG) showed significant potential as natural biomaterials for biomedical use. Full article
(This article belongs to the Special Issue Antioxidant Materials with Additional Biological Properties)
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