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Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Uncovering the Intricate Relationship Between the Human Microbiome and Chronic Diseases

edited by

Zheng Wang

submission deadline 28 Feb 2026 | Viewed by 172 | Submission Open

Keywords: gut microbiome; oral microbiome; metabolomics; proteomics; inflammation; multi-omics; diet; cardiovascular diseases; type 2 diabetes mellitus

(This special issue belongs to the Section Medical Biology)

Algal Stress Responses: Molecular and Ecological Perspectives

edited by

Chih-Ching Chung

submission deadline 28 Feb 2026 | Viewed by 164 | Submission Open

Keywords: phytoplankton; stress; global changes

(This special issue belongs to the Section Ecology)

Effects of Ionizing Radiation on Biomolecular Systems

edited by Antonella Bertucci

submission deadline 28 Feb 2026 | Viewed by 109 | Submission Open

Keywords: biomarkers; ionizing radiation; omics; high-throughput; dose

(This special issue belongs to the Section Biophysics)

Transcription Factors and Signaling Pathways in Tooth and Craniofacial Development

edited by Devi Atukorallaya

submission deadline 28 Feb 2026 | Viewed by 81 | Submission Open

Keywords: teeth; taste buds; facial bones and cartilage; animal models; birth defects; dental hard tissue development and mineralization; regeneration; cell signaling pathways

(This special issue belongs to the Section Biochemistry and Molecular Biology)

The Biology, Ecology, and Management of Plant Pests

edited by

Lei Bian

Yu Gao

, Suli Liu and Yuxin Zhou

submission deadline 1 Mar 2026 | 5 articles | Viewed by 2831 | Submission Open

Keywords: climate change; genetic diversity; life table; population dynamic; biomathematics; insect behavior; insect physiology; pest resistance; molecular mechanism; olfactory peripheral neurons; insecticide resistance; plant– pest– natural enemy; plant– insect-vector– pathogen; integrated pest management; pest monitoring and early warning

(This special issue belongs to the Section Ecology)

Physiological and Pathophysiological Responses to Biomaterials 2.0: From Nano- to Microscale Effects and Interactions

edited by

Amilcare Barca

Marta Madaghiele

and

Stefania Scialla

submission deadline 31 Mar 2026 | 4 articles | Viewed by 11352 | Submission Open

Keywords: extracellular stimuli and physiological responses; plasma membrane interface; cell– material interactions; tissue– material interactions; tissue engineering; biomaterials; biomedical devices; in vitro models and on-chip/microfluidic systems; bioreactors; structure– function relationship

(This special issue belongs to the Section Physiology)

Proteomics and Human Diseases

edited by Lei Fang

submission deadline 31 Mar 2026 | 4 articles | Viewed by 7799 | Submission Open

Keywords: proteomics; clinical proteomics; human diseases; biomarker identification; therapeutic target; molecular mechanism; cancers; metabolic diseases; cardiovascular diseases; neurodegeneration diseases

(This special issue belongs to the Section Medical Biology)

The Emerging Role of Mitochondria in Neurobiology

edited by

Filipe V. Duarte

and

Claudia Deus

submission deadline 31 Mar 2026 | 1 articles | Viewed by 4569 | Submission Open

Keywords: mitochondrial dynamics; neurodegenerative diseases; neuronal bioenergetics; synaptic function; neurogenesis; neuronal plasticity

(This special issue belongs to the Section Neuroscience)

Pathophysiology of Testis

edited by María Susana Theas,

Mónica Beatriz Frungieri

and María Noel Galardo

submission deadline 31 Mar 2026 | 1 articles | Viewed by 3124 | Submission Open

Keywords: testis; infertility; aging; inflammation; spermatogenesis; steroidogenesis; energy balance

(This special issue belongs to the Section Physiology)

How Epigenetics Shapes the Nervous System

edited by

Andrea Stoccoro

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2916 | Submission Open

Keywords: nervous system; epigenetics; DNA methylation; histone tail modifications; non-coding RNAs; neurological disorders; neurodegenerative diseases; biomarkers; environmental epigenetics

(This special issue belongs to the Section Neuroscience)

Gene–Environment Interactions in Evolutionary Developmental Biology

edited by Alexander Shingleton

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2259 | Submission Open

Keywords: phenotypic plasticity; gene– environment interactions; genetic architecture of plasticity; mechanisms of phenotypic variation; anthropogenic stressors; evolution of plastic responses

(This special issue belongs to the Section Evolutionary Biology)

Microbial Life at the Extremes: From Environmental Diversity to Functional Insights

edited by

Ramganesh Selvarajan

and

Henry Joseph Oduor Ogola

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2019 | Submission Open

Keywords: extremophiles; microbial diversity; functional adaptation; extreme environment; synthetic extreme environments; biosignatures TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Ecology)

Animal Models of Gastrointestinal Diseases

edited by Yan Hu

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1908 | Submission Open

Keywords: gastrointestinal diseases; animal models; digestive system; inflammatory bowel diseases; colorectal cancer; disease pathology; research methodologies; therapeutic interventions; clinical applications; translational research

(This special issue belongs to the Section Physiology)

Advances in Biological Research of Chiroptera

edited by Jiang Feng, Ying Liu and

Hui Wang

submission deadline 31 Mar 2026 | 4 articles | Viewed by 1853 | Submission Open

Keywords: individual development; ecolocation; powered flight; high-frequency hearing; pest control; bat ecosystem service; habitat suitability; evolutionary adaptations

(This special issue belongs to the Section Zoology)

Gene Editing and Genetic Regulation: New Insight in Insect Sex Determination, Reproductive Development and Pest Control

edited by Honglun Bi

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1730 | Submission Open

Keywords: insect gene editing; genetic regulation ; CRISPR/Cas ; gene drive ; pest control; sex determination ; reproductive development; insect sterile technique

(This special issue belongs to the Section Zoology)

Biological Control and Molecular Biology of Bacterial Plant Diseases

edited by Lei Li and Xiaofeng Zhou

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1698 | Submission Open

Keywords: bacterial plant diseases; biological control; plant pathogens; endophytes; genomic; transcriptomic; and proteomic studies of antagonistic or pathogenic bacteria interactions; pathogenic mechanism

(This special issue belongs to the Section Plant Science)

Exploring the Biodiversity, Taxonomy, Ecology and Genomics of Fungi

edited by

Chitrabhanu S. Bhunjun

Chayanard Phukhamsakda

and

Sajeewa Maharachchikumbura

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1568 | Submission Open

Keywords: biodiversity; ecological roles of fungi; fungal communities; genomics; polyphasic approaches; metabolomics

Aquatic Animal Pathogens and Immunity

edited by

Myung-hwa Jung

and Junsoung Kwak

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1311 | Submission Open

Keywords: disease mechanism; diagnosis methods for emerging diseases; host– pathogen interaction; immune defense mechanism; vaccines; immunostimulants; disease control and prevention; therapy

(This special issue belongs to the Section Microbiology)

In Vitro 2.0—Improving the Cell Culture Environment for Biology

edited by

Marcus Krüger

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1043 | Submission Open

Keywords: in vitro technologies; microfluids; bioreactors; organoids; tissue engineering; lab-on-a-chip; life-support systems; symbioses

(This special issue belongs to the Section Cell Biology)

Cardiovascular Autonomic Function: From Bench to Bedside—2nd Edition

edited by

Vera Geraldes

and

Isabel Rocha

submission deadline 31 Mar 2026 | 1 articles | Viewed by 910 | Submission Open

Keywords: dysautonomia; heart rate variability; autonomic function testing; cardiovascular autonomic function; autonomic neuroscience; syncope; orthostatic hypotension; baroreflex; autonomic molecular mechanisms

Biodiversity, Conservation, and Application of Crustaceans

edited by

Laorsri Sanoamuang

and Alejandro M. Maeda-Martinez

submission deadline 31 Mar 2026 | 1 articles | Viewed by 847 | Submission Open

Keywords: application; aquaculture; aquatic ecology; biodiversity and conservation; crustaceans; evolutionary biology; experimental toxicology; genetic diversity; phylogenetic relationships; taxonomy and classification

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Decoding the Molecular Landscape of Atopic Dermatitis: Bridging Mechanisms, Biomarkers, and Therapeutics

edited by

Ge Peng

and

Francois Niyonsaba

submission deadline 31 Mar 2026 | Viewed by 234 | Submission Open

Keywords: atopic dermatitis; molecular pathogenesis; immune dysregulation; epidermal barrier dysfunction; skin microbiome; cytokine signaling; JAK-STAT pathway; therapeutic biomarkers; precision dermatology; neuroimmune interactions

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Latest Biological Advances in Neuromuscular Diseases

edited by James P. Orengo

submission deadline 31 Mar 2026 | Viewed by 215 | Submission Open

Keywords: neuromuscular medicine; muscle disease; neuropathy; neurogenetics; neurological disorders; neurodegeneration; neurology

(This special issue belongs to the Section Neuroscience)

Molecular Insights into the Immune Contexture of Tumors

edited by

Leonardo Oliveira Reis

and Guilherme Zweig Rocha

submission deadline 31 Mar 2026 | Viewed by 148 | Submission Open

Keywords: immunology; immune oncology; cancer; molecular biology; biomarkers; inflammation

(This special issue belongs to the Section Cancer Biology)

Advances in the Molecular Evolution of Free-Living and Plant Parasitic Nematodes

edited by

Francesca De Luca

submission deadline 31 Mar 2026 | Viewed by 134 | Submission Open

Keywords: biodiversity; biogeography; criptic species; phylogenetics; sequencing

(This special issue belongs to the Section Zoology)

Signaling Mechanisms Controlling Cell Fate in Cancer

edited by Wittaya Chaiwangyen and

Orawan Khantamat

submission deadline 31 Mar 2026 | Viewed by 88 | Submission Open

Keywords: cell fate; cancer signaling; miRNA; p53; Wnt; apoptosis; proliferation; differentiation; therapy resistance; biomarkers

(This special issue belongs to the Section Cell Biology)

Bird Biology and Conservation

edited by

Alessandro Ferrarini

submission deadline 15 Apr 2026 | 12 articles | Viewed by 16141 | Submission Open

Keywords: avian conservation; ecological modeling; GIS; spatial ecology; telemetry

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Mitochondria: The Signaling Organelle

edited by

Nathan Lanning

submission deadline 15 Apr 2026 | 3 articles | Viewed by 6560 | Submission Open

Keywords: mitochondria; signal transduction; homeostasis; metabolism; apoptosis; redox biology; organelle communication

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Maternal Adaptation in Physiological and Pathological Pregnancy (2nd Edition)

edited by

Qi Chen

and

Yunhui Tang

submission deadline 15 Apr 2026 | Viewed by 170 | Submission Open

Keywords: pregnancy; maternal adaptation; placenta; cardiovascular system; immune system; complications of preg-nancy; early prediction

(This special issue belongs to the Section Developmental and Reproductive Biology)

Microbial Drivers of Aquatic Ecosystem Function: From Genomes to Biogeochemical Cycles

edited by

Ji Li

and Jinjun Kan

submission deadline 15 Apr 2026 | Viewed by 93 | Submission Open

Keywords: aquatic microbial ecology; harmful algal blooms; nutrient cycling; trophic interactions; omics technologies; ecosystem resilience; bioremediation; population dynamics in aquatic ecosystems

(This special issue belongs to the Section Marine Biology)

Biology, Ecology, Management and Conservation of Canidae

edited by Alberto Meriggi and

Francesco Maria Angelici

submission deadline 30 Apr 2026 | 8 articles | Viewed by 17775 | Submission Open

Keywords: Canidae; biology; ecology; management; conservation; ecosystem; habitats; niches; biodiversity; physiology; reproduction

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Zoonotic Diseases

edited by

Francesca Mancianti

and

Valentina Virginia Ebani

submission deadline 30 Apr 2026 | 6 articles | Viewed by 7548 | Submission Open

Keywords: zoonoses; zoonotic agents; bacteria; viruses; fungi; protozoa; helminths

(This special issue belongs to the Section Infection Biology)

Application of Metabolomics and Integrated Computing in Chemical Biology

edited by

Saheed Sabiu

submission deadline 30 Apr 2026 | 3 articles | Viewed by 5378 | Submission Open

Keywords: chemical biology; computational biology; metabolomics; computational modeling; new chemical entities (NCE); active pharmaceutical ingredients (API); characterization; metabolite profiling

Machine Learning Applications in Biology—2nd Edition

edited by

Georgios K. Georgakilas

submission deadline 30 Apr 2026 | 3 articles | Viewed by 4325 | Submission Open

Keywords: machine learning; genomics; epigenomics; genetic variation and the environment; gene regulatory networks; integration of multipurpose NGS data

(This special issue belongs to the Section Bioinformatics)

Advances in Systems Metabolic Engineering for Biochemicals Production

edited by

Huan Liu

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3473 | Submission Open

Keywords: systems metabolic engineering; biochemicals; synthetic biology; bioprocess engineering; pathway modification; strain development

(This special issue belongs to the Section Microbiology)

Advancing Translational Science Using Bioinformatics and Big Data-Driven Approaches

edited by

Zongliang Yue

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3018 | Submission Open

Keywords: bioinformatics; big data analytics; artificial intelligence (AI); machine learning; deep learning; translational science; computational biology; drug repositioning; biomarker discovery; genomics; medical imaging; digital pathology; integrative analysis; disease mechanisms; functional genomics analysis; computational tool application; ethical and safety considerations; data-driven approaches

(This special issue belongs to the Section Bioinformatics)

Molecular Basis of Seed Germination and Dormancy

edited by

Yifeng Wang

Jiezheng Ying

Xiaohong Tong

and Yu Cheng

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2745 | Submission Open

Keywords: molecular mechanism; genetic basis; seed germination; dormancy; genetic improvement

(This special issue belongs to the Section Plant Science)

Epigenetic and Genetic Control of Sperm Development and Function: From Fertility to Inheritance

edited by

Candela Rocío González

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2342 | Submission Open

Keywords: spermatogenesis; epigenetics; sperm; male fertility; DNA methylation; histone modifications; small RNAs; epigenetic inheritance

(This special issue belongs to the Section Genetics and Genomics)

Recent Advances in Animal Anatomy

edited by

Korakot Nganvongpanit

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2331 | Submission Open

Keywords: animal anatomy; comparative morphology; imaging anatomy; molecular anatomy; veterinary anatomy; functional morphology; evolutionary biology; wildlife conservation; developmental anatomy; anatomical adaptations

(This special issue belongs to the Section Zoology)

Natural Compounds Targeting 12 Hallmarks of Aging: A Path to Longevity Intervention

edited by

Tawin Iempridee

and

Wannita Klinngam

submission deadline 30 Apr 2026 | Viewed by 885 | Submission Open

Keywords: natural compounds; antiaging interventions; hallmarks of aging; telomere; epigenetics; autophagy; cellular senescence; pharmaceuticals

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Advances in Cell and Experimental Biology: Cellular Organelle Stress and Homeostasis in Physiology and Diseases

edited by

Wen-Xing Ding

submission deadline 30 Apr 2026 | 1 articles | Viewed by 669 | Submission Open

Keywords: autophagy; integrated stress response; proteotoxic stress response; organelle homeostasis; ubiquitination

(This special issue belongs to the Section Cell Biology)

The Molecular Mechanisms of Chronic Inflammation Occurrence and Development

edited by Meixiu Jiang

submission deadline 30 Apr 2026 | 1 articles | Viewed by 543 | Submission Open

Keywords: atherosclerosis; vascular calcification; neointima; macrophage; inflammation; phenotypic transformation of smooth muscle cell; endothelial dysfunction

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Germplasm Resources and Molecular Breeding for Sustainable Aquatic Species Improvement

edited by

Falin Zhou

submission deadline 30 Apr 2026 | 1 articles | Viewed by 382 | Submission Open

Keywords: germplasm resource evaluation; molecular marker; genomics; gene editing; selective breeding; environment adaptation

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Machine Learning in Pathogen Discovery

edited by

Hong Li

submission deadline 30 Apr 2026 | Viewed by 363 | Submission Open

Keywords: pathogen; machine learning; disease; antibiotic; virulence

(This special issue belongs to the Section Bioinformatics)

Effects of Aquatic Sediments on Marine Ecosystems

edited by Ehui Tan and Sibo Zhang

submission deadline 30 Apr 2026 | Viewed by 344 | Submission Open

Keywords: biogeochemical cycling processes; microbial activity; sediment– water interface; benthic organisms; pollutants; global change; nutrients; environmental issues

(This special issue belongs to the Section Ecology)

Animal Models for Disease Mechanisms (2nd Edition)

edited by

Isabel R. Dias

submission deadline 30 Apr 2026 | Viewed by 165 | Submission Open

Keywords: animal models; spontaneous models; induced models; disease mechanisms; pathogenesis research

(This special issue belongs to the Section Zoology)

Research Progress in Microbial Genetics and Genomics

edited by

Rapee Thummeepak

and Udomluk Leungtongkam

submission deadline 30 Apr 2026 | Viewed by 153 | Submission Open

Keywords: antimicrobial resistance (AMR); microbial genetics and genomics; high-throughput DNA sequencing; comparative genomics and pan-genome; metagenomics and microbiome; mobilome; resistome and virulome; medical microbiology; environmental and food microbiology; probiotic genomics; bacteriology; mycology and virology

(This special issue belongs to the Section Microbiology)

Natural Compound–Drug Interactions Related to Metabolizing Enzymes and Transporters

edited by

Mei Hong

submission deadline 30 Apr 2026 | Viewed by 137 | Submission Open

Keywords: drug transporters; drug-metabolizing enzymes; natural products; herb– drug interactions; food– drug interactions; nuclear receptors; kinases; expression regulation; protein targeting; functional regulation

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Cutting-Edge Biomechanics: Unlocking the Future of Biomedical Engineering

edited by

Ye Zeng

submission deadline 30 Apr 2026 | Viewed by 123 | Submission Open

Keywords: computational biomechanics; experimental biomechanics; cellular and molecular biomechanics; tissue biomechanics and regenerative engineering; cardiovascular biomechanics; musculoskeletal biomechanics; sports and injury biomechanics; biomaterials and medical device innovation; medical robotics and haptics; AI and machine learning in biomechanics

(This special issue belongs to the Section Biophysics)

Advances in Cell Division and Chromosome Segregation Mechanisms

edited by

Zhixin (Jason) Lyu

submission deadline 30 Apr 2026 | Viewed by 91 | Submission Open

Keywords: cell division; chromosome segregation; bacterial cell biology; mammalian cell cycle; genome stability; cytoskeletal dynamics; structural biology; advanced imaging

(This special issue belongs to the Section Cell Biology)

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