Natural Compound–Drug Interactions Related to Metabolizing Enzymes and Transporters
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 42
Special Issue Editor
2. Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, South China Agricultural University, Guangzhou 510642, China
Interests: transporters; structure-function relationship; post-translational modifications; radiobiology
Special Issue Information
Dear Colleagues,
Natural compounds derived from plants have long been recognized to possess bio/pharmacological activities. These compounds serve not only as traditional medicine or complementary and alternative medicine to treat various diseases, but they are also increasingly popular for self-medication and as part of a healthy daily diet. While natural compounds are often seen as having fewer side effects than synthetic substances, research has shown that many of these compounds can influence the function and expression of metabolizing enzymes and transporters. As a result, the potential interactions between natural compounds and over-the-counter or prescription medications have become a growing concern in recent years. Most previous studies have concentrated on how natural compounds directly affect protein function. However, many natural products act as modulators of regulatory proteins, such as nuclear receptors and kinases, which play a role in regulating metabolizing enzymes and drug transporters. These compounds can not only change the activity of these proteins but also influence their expression levels, localization, and/or conformation. Information on this type of regulation is limited and should be explored more thoroughly to provide a comprehensive understanding of natural product-drug interactions and their potential clinical implications.
Prof. Dr. Mei Hong
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- drug transporters
- drug-metabolizing enzymes
- natural products
- herb–drug interactions
- food–drug interactions
- nuclear receptors
- kinases
- expression regulation
- protein targeting
- functional regulation
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
