Signaling Mechanisms Controlling Cell Fate in Cancer
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cell Biology".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 1147
Editors
Interests: miRNAs; epigenetics; cell signalling; biomarkers; environmental pollutants; natural products
Special Issue Information
Dear Colleagues,
We are pleased to invite you to contribute to this Special Issue titled “Signaling Mechanisms Controlling Cell Fate in Cancer”. Cancer progression fundamentally depends on dysregulated signaling pathways that control critical cellular fate decisions between survival, proliferation, differentiation, senescence, and death. Understanding these complex molecular mechanisms is essential for developing effective therapeutic strategies. The intricate interplay between classical signaling networks, epigenetic regulation, microRNA-mediated control, environmental factors, and exposure to environmental pollutants creates a sophisticated regulatory system that determines cancer cell destiny. This research area represents a cornerstone of modern cancer biology, with direct implications for personalized medicine and targeted therapy development.
This Special Issue aims to advance our understanding of how signaling networks and regulatory circuits coordinate in order to determine cancer cell fate, ultimately contributing to the development of more effective, personalized cancer treatments. We seek to compile cutting-edge research that provides mechanistic insights into cell fate control mechanisms and demonstrates clinical relevance or therapeutic potential. The scope aligns perfectly with the Journal of Biology’s focus on molecular and cellular biology, encompassing both fundamental biological processes and their applications in human health.
In this Special Issue, original research articles and reviews are welcome. Research areas may include, but are not limited to, the following:
- p53, Wnt, Notch, PI3K/AKT, MAPK, and TGF-β signaling pathways in cell fate determination.
- miRNA-mediated control of signaling pathways and cancer cell fate.
- Epigenetic regulation of cell fate decisions in cancer.
- Integrative omics and cell fate in cancer.
- Tumor microenvironment influences on cancer cell behavior.
- Environmental pollutants and their impact on cancer cell fate signaling.
- Natural products and signaling networks governing cell fate in cancer.
- Metabolic reprogramming affecting cellular destiny.
- Mechanisms of therapy resistance and cell fate plasticity.
- Cancer stem cell signaling in initiation and progression.
- Novel therapeutic targets within cell fate signaling pathways.
- Biomarkers for predicting treatment response.
We look forward to receiving your contributions.
Dr. Wittaya Chaiwangyen
Dr. Orawan Khantamat
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cell fate
- cancer signaling
- miRNA
- p53
- Wnt
- apoptosis
- proliferation
- differentiation
- therapy resistance
- biomarkers
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