Signaling Mechanisms Controlling Cell Fate in Cancer

Dear Colleagues,

We are pleased to invite you to contribute to this Special Issue titled “Signaling Mechanisms Controlling Cell Fate in Cancer”. Cancer progression fundamentally depends on dysregulated signaling pathways that control critical cellular fate decisions between survival, proliferation, differentiation, senescence, and death. Understanding these complex molecular mechanisms is essential for developing effective therapeutic strategies. The intricate interplay between classical signaling networks, epigenetic regulation, microRNA-mediated control, environmental factors, and exposure to environmental pollutants creates a sophisticated regulatory system that determines cancer cell destiny. This research area represents a cornerstone of modern cancer biology, with direct implications for personalized medicine and targeted therapy development.

This Special Issue aims to advance our understanding of how signaling networks and regulatory circuits coordinate in order to determine cancer cell fate, ultimately contributing to the development of more effective, personalized cancer treatments. We seek to compile cutting-edge research that provides mechanistic insights into cell fate control mechanisms and demonstrates clinical relevance or therapeutic potential. The scope aligns perfectly with the Journal of Biology’s focus on molecular and cellular biology, encompassing both fundamental biological processes and their applications in human health.

In this Special Issue, original research articles and reviews are welcome. Research areas may include, but are not limited to, the following:

• p53, Wnt, Notch, PI3K/AKT, MAPK, and TGF-β signaling pathways in cell fate determination.
• miRNA-mediated control of signaling pathways and cancer cell fate.
• Epigenetic regulation of cell fate decisions in cancer.
• Integrative omics and cell fate in cancer.
• Tumor microenvironment influences on cancer cell behavior.
• Environmental pollutants and their impact on cancer cell fate signaling.
• Natural products and signaling networks governing cell fate in cancer.
• Metabolic reprogramming affecting cellular destiny.
• Mechanisms of therapy resistance and cell fate plasticity.
• Cancer stem cell signaling in initiation and progression.
• Novel therapeutic targets within cell fate signaling pathways.
• Biomarkers for predicting treatment response.

We look forward to receiving your contributions.

Dr. Wittaya Chaiwangyen
Dr. Orawan Khantamat
Guest Editors

Manuscript Submission Information

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