Advances in Cell Division and Chromosome Segregation Mechanisms

Dear Colleagues,

Cell division and chromosome segregation are fundamental processes that ensure the faithful inheritance of genetic material across all domains of life. In bacteria and mammalian cells alike, these events must be tightly coordinated to achieve accurate DNA replication, chromosome partitioning, and cell cycle progression. Errors in these processes compromise genome stability and can lead to developmental abnormalities, chromosomal instability, and severe diseases, including cancer.

Recent advances have uncovered remarkable insights into how diverse organisms organize and regulate division and segregation. In bacteria, studies continue to reveal the dynamic interplay between cytoskeletal elements, DNA organization, and cell envelope remodeling. In mammalian cells, extensive work has defined complex regulatory networks that govern mitosis, chromosome condensation, and checkpoint control. Together, these discoveries highlight both conserved strategies and unique adaptations across life forms.

This Special Issue, “Advances in Cell Division and Chromosome Segregation Mechanisms”, aims to showcase progress in this critical area by bringing together original research and reviews. Cutting-edge approaches such as single-molecule imaging, super-resolution microscopy, cryo-electron microscopy, and computational modeling are also featured, providing fresh insights into the organization and regulation of these complex systems. By integrating bacterial and mammalian perspectives, this collection seeks to foster cross-disciplinary exchange, inspire new collaborations, and advance our understanding of how these essential processes shape health and disease.

Dr. Zhixin (Jason) Lyu
Guest Editor

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