Integrative Immunology of the Skin: Unraveling Molecular Networks in Allergy, Autoimmunity, and Inflammation
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 302
Special Issue Editors
Interests: skin barrier; antimicrobial peptide; atopic dermatitis; allergy; skin inflammation
Special Issue Information
Dear Colleagues,
Immune-mediated skin diseases encompass a broad spectrum of allergic, autoimmune, and chronic inflammatory conditions in which dysregulated immune responses interact with epithelial, stromal, neural, and microbial components of the skin. Advances in single-cell technologies, spatial transcriptomics, and multi-omics integration have transformed our understanding of these disorders, revealing complex molecular networks that transcend traditional diagnostic categories. These approaches are uncovering shared immune circuits—such as type 2 inflammation, IL-17/IL-23 signaling, interferon pathways, and neuroimmune crosstalk—as well as disease-specific programs that shape heterogeneity, clinical phenotype, and therapeutic responses.
Despite rapid progress, key challenges remain unresolved. The mechanisms driving inter- and intra-disease variability, the determinants of chronicity and flare dynamics, and the interaction between environmental exposures, microbiota, and tissue-resident immunity are still poorly understood. Bridging these gaps requires an integrative, systems-level perspective that unites insights across allergy, autoimmunity, and inflammatory skin disorders.
This Special Issue, Integrative Immunology of the Skin: Unraveling Molecular Networks in Allergy, Autoimmunity, and Inflammation, invites contributions that advance mechanistic understanding and highlight innovative methodologies. We welcome reviews, perspectives, and original research that elucidate molecular pathways, tissue responses, and cross-disciplinary approaches shaping the future of skin immunology.
We warmly invite your contributions.
Dr. Ge Peng
Prof. Dr. Francois Niyonsaba
Guest Editors
Manuscript Submission Information
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Keywords
- skin immunology
- allergy and autoimmunity
- chronic inflammation
- cytokine and molecular networks
- neuroimmune and microbiome interactions
- systems immunology
- multi-omics and spatial biology
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