Epigenetic and Genetic Control of Sperm Development and Function: From Fertility to Inheritance
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Genetics and Genomics".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 472
Special Issue Editor
Special Issue Information
Dear Colleagues,
The development of functional spermatozoa requires a tightly regulated process of gene expression and chromatin remodeling throughout spermatogenesis. In recent years, increasing evidence has highlighted the role of epigenetic mechanisms—such as DNA methylation, histone modifications, and small RNAs—in orchestrating these processes and ensuring the production of competent sperm. Aberrant epigenetic programming in male germ cells has been associated with impaired fertility, altered sperm quality, and adverse outcomes in assisted reproductive technologies. Beyond their role in male fertility, sperm-borne epigenetic marks have emerged as key players in the transmission of acquired traits and environmental information to the next generation. Studies in animal models and humans have demonstrated that paternal lifestyle, such as diet, stress, and toxic exposures, can shape the sperm epigenome and affect offspring development, health, and disease risk. This growing field of research opens new avenues for understanding the intergenerational impact of male exposures and the potential reversibility of epigenetic alterations. This Special Issue aims to gather original research articles and reviews focusing on epigenetic regulation during sperm development, the impact of environmental and lifestyle factors on the sperm epigenome, and the implications of epigenetic inheritance for offspring health. We welcome contributions exploring molecular mechanisms, model systems, and translational approaches that expand our knowledge of sperm epigenetics and its relevance in reproduction and beyond.
Dr. Candela Rocío González
Guest Editor
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Keywords
- spermatogenesis
- epigenetics
- sperm
- male fertility
- DNA methylation
- histone modifications
- small RNAs
- epigenetic inheritance
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