How Epigenetics Shapes the Nervous System
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Neuroscience".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 63
Special Issue Editor
Interests: neurobiology; neurodegeneration; epigenetic biomarkers; environmental factors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs, regulate gene expression, influencing neural differentiation, synaptic remodeling, and cognitive processes. These mechanisms play a crucial role in the development, function, and plasticity of the nervous system. Emerging evidence also links altered epigenetic regulation to neurological disorders, neurodegenerative diseases, and psychiatric conditions, offering novel insights into disease pathogenesis and potential therapeutic strategies. Notably, neurodevelopmental disorders caused by germline mutations in genes encoding epigenetic regulators, known as chromatinopathies, underscore the profound impact of epigenetic mechanisms on central nervous system function.
This Special Issue aims to bring together cutting-edge research and reviews exploring the diverse roles of epigenetic modifications in neural development, function, and disease. We welcome contributions exploring the fundamental mechanisms of neuro-epigenetics and translational research investigating altered epigenetic mechanisms underlying neurological disorders, as well as studies exploring the therapeutic potential of targeting the epigenome. Additionally, we encourage contributions examining the impact of environmental and early-life factors on epigenetic modifications in the nervous system, along with updated reviews and systematic reviews on specific aspects of neuro-epigenetics. By assembling a comprehensive collection of studies, we seek to advance our understanding of how epigenetics shapes nervous system biology and contributes to neuropathology, paving the way for novel diagnostic and therapeutic strategies.
We look forward to receiving your contributions.
Dr. Andrea Stoccoro
Guest Editor
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Keywords
- nervous system
- epigenetics
- DNA methylation
- histone tail modifications
- non-coding RNAs
- neurological disorders
- neurodegenerative diseases
- biomarkers
- environmental epigenetics
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