Maternal Adaptation in Physiological and Pathological Pregnancy (2nd Edition)
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Developmental and Reproductive Biology".
Deadline for manuscript submissions: 15 April 2026 | Viewed by 48
Special Issue Editors
Interests: placenta; pregnancy; complications of pregnancy; endothelial cells; extracellular vesicles; gynaecological cancers
Special Issues, Collections and Topics in MDPI journals
Interests: placenta; placental development and metabolism; placenta extracellular vesicles; complicated pregnancies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
To achieve a successful pregnancy, without damage to maternal or foetal health, a number of maternal adaptive changes are required in response to the induced reset of various cardiovascular and immune regulatory receptors. These natural changes include increased cardiac output, expanded blood volume, and reduced systemic vascular resistance, blood pressure, and immune tolerance. The importance of these adaptive changes is clear, as failure in maternal adaptation could result in the development of complications, including preeclampsia, miscarriage, and foetal growth restriction. However, it is clear that our current insights into normal and defective adaptation to pregnancy are incomplete, and the triggers for this reset are largely unknown. Currently, increasing evidence suggests that the placenta plays an important role in the process of maternal adaptation in the early stages. This is because several complications are collectively referred to as placental dysfunction or placental syndrome, resulting in a maladaptive maternal response. A better understanding of maternal adaptation between physiological and pathological conditions during pregnancy could pave the way for the development of strategies for early prediction, intervention, and prevention if needed.
The purpose of the Special Issue is to better understand the mechanisms underlying the development of maternal adaptation. This Special Issue will focus on (1) maternal adaptation in physiological and pathological conditions during pregnancy and (2) the early prediction of pathological pregnancies potentially resulting from a maladaptive maternal response. We welcome papers on topics including, but not limited to, placenta-tion, placental metabolism, placental development, placental pathology, clinical aspects of maternal cardio-vascular changes, and the assessment of biomarkers of placental disorders.
Dr. Qi Chen
Dr. Yunhui Tang
Guest Editors
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Keywords
- pregnancy
- maternal adaptation
- placenta
- cardiovascular system
- immune system
- complications of preg-nancy
- early prediction
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