Uncovering the Intricate Relationship Between the Human Microbiome and Chronic Diseases
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 83
Special Issue Editor
Special Issue Information
Dear Colleagues,
Recent advancements in high-throughput omics techniques have greatly enhanced our understanding of the human microbiome’s role in the development of chronic diseases, including cardiovascular diseases, inflammatory bowel disease, chronic kidney disease, obesity, and diabetes. Emerging evidence indicates that microbial communities across multiple body sites — such as the gut microbiome, oral microbiome, and other microbiomes—may play pivotal roles in chronic disease pathogenesis. The potential mechanisms by which the human microbiome influences these conditions span systemic inflammation, immune responses, microbial translocation, and the impact of microbial-derived products such as microbial metabolites and specific toxins.
This current Special Issue of the journal Biology, entitled “Uncovering the Intricate Relationship Between the Human Microbiome and Chronic Diseases”, invites you to contribute original research and review papers that showcase the use of cutting-edge microbiome and omics technologies to explore the dynamic crosstalk between the human microbiome and chronic diseases. In addition, this Special Issue will also investigate the diet–microbiome–physiology axis. The goal of this Special Issue is to synthesize current knowledge on microbiome–disease connections and identify critical microbial and biochemical targets. By collating innovative findings, we hope to reveal the potential underlying mechanisms and shed light on microbiome-related diagnostic, preventive, and therapeutic strategies for chronic disease management.
Dr. Zheng Wang
Guest Editor
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Keywords
- gut microbiome
- oral microbiome
- metabolomics
- proteomics
- inflammation
- multi-omics
- diet
- cardiovascular diseases
- type 2 diabetes mellitus
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