Discovery and Design of New Antimicrobial Agents

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Novel Antimicrobial Agents".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 243

Special Issue Editor

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Guest Editor
UMR_MD1, Faculté de Pharmacie, Aix-Marseille Universite, 27 Bd Jean Moulin, CEDEX 5, 13385 Marseille, France
Interests: antimicrobial agents; antibiotic enhancers; organic chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The abuse of antibiotics has accelerated the phenomenon of antibiotic resistance and the discovery of new antimicrobials, as well as the expansion of utility of existing antibiotics, remains a priority to fight the ever-increasing antimicrobial resistance of “superbugs”, pathogenic fungi, etc. This Special Issue of Antibiotics entitled “Discovery and Design of New Antimicrobial Agents” will discuss the chemistry involved in the design and synthesis of original scaffolds, as well as biologically inspired molecules from nature. The structure–activity relationships of these molecules will be also examined to demonstrate the wide interest of chemists as well as biologists, marine scientists, and pharmacologists. The report of strategies to fight antimicrobial resistance by depicting original mechanisms of action against bacteria will be highlighted in this dedicated Special Issue.

Dr. Jean Michel Brunel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • antimicrobial agents
  • fight resistance
  • new design
  • structure–activity relationships (SAR)

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: An Insight in the Rational Drug Design: The Development of In–House Azolic Compounds with Antimicrobial Potential
Authors: Daniel Ungureanu
Affiliation: Romania
Abstract: Antimicrobial resistance poses a major threat for the global health, as the number of efficient antimicrobials decrease and the number of resistant pathogens rises. Our research group has been actively involved in the design of novel antimicrobial drugs for almost 50 years. The blueprints of these compounds were the azolic heterocycles, particularly the thiazole heterocycle. Starting from oxadiazolines, our research group explored one by one the other five-membered heterocycles, developing more or less potent compounds. As the years passed the number of assays employed for the antimicrobial evaluation grew, starting with the disk diffusion method and adding the minimal inhibitory concentration determinations and the antibiofilm potential evaluation. Finally, in the last few years, in silico methods were introduced in the design of novel compounds, providing more efficiency and reducing the necessary time for research and development. The purpose of this review is to present the development of in-house azolic compounds with antimicrobial potential, designed over the years by the research group from the department of Pharmaceutical Chemistry in Cluj-Napoca, starting from 1999.

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