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Antibiotics
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Antimicrobial Activity of Different Plant Extracts, Plant-Derived Compounds and Synthetic...
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Antimicrobial Activity of Different Plant Extracts, Plant-Derived Compounds and Synthetic Derivatives of Natural Compounds on Pathogenic Microorganisms, 3rd Edition

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Plant-Derived Antibiotics".

Deadline for manuscript submissions: closed (28 February 2026) | Viewed by 1495

Special Issue Editors

Dr. Anna Duda-Madej

E-Mail Website
Guest Editor
Department of Microbiology, Faculty of Medicine, Wroclaw Medical University, Chałubińskiego 4, 50-368 Wrocław, Poland
Interests: flavonoid; natural compounds; biological activity; anticancer activity; antioxidant activity; chalcone; multidrug-resistant pathogens; food science; antimicrobial agents; cytotoxicity assays; amyloid; Crohn’s disease; AIEC; biofilm
Special Issues, Collections and Topics in MDPI journals
Dr. Joanna Kozłowska

E-Mail Website
Guest Editor
Department of Food Chemistry and Biocatalysis, The Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, Wrocław, Poland
Interests: flavonoids; plant extracts; natural compounds; biotransformations; antimicrobial activity; antitumor activity; antioxidant activity
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Katarzyna Wińska

E-Mail Website1 Website2
Guest Editor
Department of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland
Interests: enzymatic catalysis; biotransformation; organic synthesis; isolation natural products; chemistry of cosmetic
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We have published two successful volumes of the Special Issue “Antimicrobial Activity of Different Plant Extracts, Plant-Derived Compounds and Synthetic Derivatives of Natural Compounds on Pathogenic Microorganisms" 

https://www.mdpi.com/journal/antibiotics/special_issues/Plant_Antimic

https://www.mdpi.com/journal/antibiotics/special_issues/IO32O463Z8

This result encouraged us to produce the third volume on the same topic.

This third volume will include research and manuscripts regarding plant extracts and novel compounds, mainly of natural origin, characterized by strong biological activity. Research on alternative methods of obtaining new derivatives of natural origin is also welcome. Manuscripts that present the antimicrobial activity of natural compounds, including plant extracts and chemical compounds commonly known for their synthetic derivatives, will be appreciated. Manuscripts on the biological activity of natural extracts without proper chemical characterization will not be considered.

Dr. Anna Duda-Madej
Dr. Joanna Kozłowska
Prof. Dr. Katarzyna Wińska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial activity
  • plant extracts
  • plant-derived compounds
  • synthetic derivatives
  • flavonoids
  • multidrug resistance
  • pathogenic strains

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Related Special Issues

Published Papers (2 papers)

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Research

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40 pages, 19255 KB  
Article
Integrated Phytochemical Profiling and Bioactivity Evaluation of Micromeria nervosa, with Emphasis on Antimicrobial and Antiviral Properties
by Ljuboš Ušjak, Krystyna Skalicka-Woźniak, Łukasz Kulinowski, Łukasz Świątek, Violeta Milutinović, Kinga Salwa, Anastazja Boguszewska, Izabela Korona-Glowniak, Katarzyna Suśniak, Marjan Niketić, Jelena Kukić Marković and Silvana Petrović
Antibiotics 2026, 15(4), 374; https://doi.org/10.3390/antibiotics15040374 - 6 Apr 2026
Viewed by 731
Abstract
Background/Objectives: Lamiaceae species are valuable sources of bioactive natural products, often associated with anti-infective properties. This study investigated chemical composition and bioactivities of dry hydroethanolic extracts and essential oils from Micromeria nervosa (Desf.) Benth. aerial parts from two localities. Methods: Extracts [...] Read more.
Background/Objectives: Lamiaceae species are valuable sources of bioactive natural products, often associated with anti-infective properties. This study investigated chemical composition and bioactivities of dry hydroethanolic extracts and essential oils from Micromeria nervosa (Desf.) Benth. aerial parts from two localities. Methods: Extracts and essential oils were analyzed using LC-DAD-QTOF-MS/MS and GC-FID/MS, respectively. Antimicrobial activity was assessed against 14 strains (microdilution method), and antiviral activity against three viruses by determining cytopathic effects, viral titers (end-point dilution assay) and viral loads (qPCR/RT-qPCR). Cytotoxicity was evaluated on three cancer cell lines (MTT assay) and antioxidant potential using three colorimetric tests. Composition–activity correlation was statistically analyzed; in silico molecular docking/dynamics simulations were performed. Results: Thirty-five compounds were annotated in extracts, including 30 reported for the first time in this species, with rosmarinic acid as the main component. Essential oils contained 31 constituents, dominated by carvacrol. Newly detected phenolics included lithospermic acid and several salvianolic and clinopodic acids. Extracts and oils exhibited notable antibacterial activity, especially against five Gram-positive strains (MIC = 0.313–2.5 mg/mL), and oils showed marked anticandidal effects (MIC = 0.313–0.625 mg/mL) and enhanced cytotoxicity against colon, gastric and hypopharyngeal cancer cells (selectivity indices ≥ 1.66). Extracts displayed potent antiviral activity against human herpesvirus 1 (HHV-1) and adenovirus Ad5, reducing cytopathic effects and viral titers, with qPCR revealing decreased HHV-1 load. In silico analysis suggested HHV-1 glycoprotein D binding. Extracts also showed strong antioxidant potential. Conclusions: These findings demonstrate that M. nervosa is a rich source of compounds with antimicrobial/antiviral, cytotoxic and antioxidant activities, warranting further research. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Different Plant Extracts, Plant-Derived Compounds and Synthetic Derivatives of Natural Compounds on Pathogenic Microorganisms, 3rd Edition)
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Review

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18 pages, 1653 KB  
Review
Sulbactam–Durlobactam in the Treatment of Multidrug-Resistant Acinetobacter baumannii: A Narrative Review
by Szymon Viscardi, Patrycja Lipska, Piotr Niezgódka and Anna Duda-Madej
Antibiotics 2026, 15(5), 499; https://doi.org/10.3390/antibiotics15050499 - 16 May 2026
Viewed by 168
Abstract
The increasing prevalence of infections caused by multidrug-resistant (MDR) Gram-negative bacteria represents a major global public health challenge. Among hospital-acquired infections (HAIs), ventilator-associated pneumonia (VAP) caused by non-fermenting Gram-negative pathogens, particularly the Acinetobacter baumannii-calcoaceticus complex, it is associated with limited therapeutic options and [...] Read more.
The increasing prevalence of infections caused by multidrug-resistant (MDR) Gram-negative bacteria represents a major global public health challenge. Among hospital-acquired infections (HAIs), ventilator-associated pneumonia (VAP) caused by non-fermenting Gram-negative pathogens, particularly the Acinetobacter baumannii-calcoaceticus complex, it is associated with limited therapeutic options and high mortality. Sulbactam–durlobactam is a novel combination consisting of sulbactam, a β-lactamase inhibitor with intrinsic activity against Acinetobacter spp., and durlobactam, a diazabicyclooctane β-lactamase inhibitor targeting Ambler class A, C, and D enzymes. This review summarizes current evidence on the pharmacological properties, clinical efficacy, and resistance mechanisms associated with this combination. Clinical trials have demonstrated that sulbactam–durlobactam is non-inferior to colistin in the treatment of infections caused by carbapenem-resistant A. baumannii, with a significantly lower risk of nephrotoxicity. The combination is generally well tolerated and represents a promising therapeutic option for difficult-to-treat infections. However, emerging resistance mechanisms, including PBP3 mutations, metallo-β-lactamase production, and efflux pump overexpression, may limit its long-term effectiveness. Further research is required to better understand resistance development and optimize clinical use. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Different Plant Extracts, Plant-Derived Compounds and Synthetic Derivatives of Natural Compounds on Pathogenic Microorganisms, 3rd Edition)
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