Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.5
4.8
Journals
Antibiotics
Special Issues
Rational Use of Antibiotics in Veterinary Medicine
share announcement

Rational Use of Antibiotics in Veterinary Medicine

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics in Animal Health".

Deadline for manuscript submissions: 10 September 2024 | Viewed by 911

Special Issue Editor

Dr. JeongWoo Kang

E-Mail
Guest Editor
1. Animal Disease Diagnosis Division, Animal and Plant Quarantine Agency (APQA), Gimcheon, Republic of Korea
2. Laboratory of Veterinary Physiology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Interests: LC-MS/MS; GC-MS/MS; veterinary medicine; veterinary forensic medicine; rapid diagnosis of antimicrobial resistance

Special Issue Information

Dear Colleagues,

We are excited to announce a call for manuscripts for a Special Issue entitled “Rational Use of Antibiotics in Veterinary Medicine”. This Special Issue is dedicated to expanding our knowledge and improving practices in the field of antibiotics, addressing several key aspects:

  1. Good manufacturing practice (GMP) in antibiotic production: We are interested in research that explores the application of GMP principles in the manufacturing of antibiotics. This includes innovations in production processes, quality control measures, and compliance with regulatory standards to ensure the production of high-quality antibiotic products;
  2. Research and systems in antibiotic quality control: We are seeking studies that explore innovative approaches in the quality control of antibiotics. This includes advancements in testing methods, regulatory frameworks, and quality assurance protocols that ensure the safety and efficacy of antibiotics;
  3. Consequences of improper antibiotic use: Manuscripts that examine the impact of antibiotic misuse are crucial. This encompasses research on the adverse effects resulting from incorrect dosages, inappropriate prescribing practices, and self-medication, which contribute to the growing problem of antibiotic resistance;
  4. Antibiotic stewardship programs: We encourage submissions that focus on the development, implementation, and evaluation of antibiotic stewardship programs. These programs are essential in promoting the appropriate use of antibiotics, optimizing patient outcomes, and reducing resistance;
  5. Antibiotic resistance management research: Studies that delve into the mechanisms of antibiotic resistance, strategies for its management, and the development of new antibiotics or alternative therapies to combat resistant strains are particularly welcome.

We believe that this Special Issue will serve as an important platform for sharing research findings, insights, and innovations in these crucial areas of antibiotic research and management. Your contributions will help in shaping better practices and policies, ultimately contributing to improved healthcare outcomes.

We look forward to receiving your submissions and to the valuable discussions that they will undoubtedly inspire.

Dr. JeongWoo Kang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • good manufacturing practice (GMP) in antibiotic production
  • research and systems in antibiotic quality control
  • consequences of improper antibiotic use
  • antibiotic stewardship programs
  • antibiotic resistance management

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

16 pages, 3404 KiB  
Article
Comparative Pharmacokinetics of Gentamicin C1, C1a and C2 in Healthy and Infected Piglets
by Eun-Young Kim, Tae-Won Kim, Elias Gebru Awji, Eon-Bee Lee and Seung-Chun Park
Antibiotics 2024, 13(4), 372; https://doi.org/10.3390/antibiotics13040372 - 18 Apr 2024
Viewed by 642
Abstract
Gentamicin, an aminoglycoside antibiotic, is a mixture of therapeutically active C1, C1a, C2 and other minor components. Despite its decades-long use in pigs and other species, its intramuscular (IM) pharmacokinetics/pharmacodynamics (PKs/PDs) are unknown in piglets. Furthermore, the PKs [...] Read more.
Gentamicin, an aminoglycoside antibiotic, is a mixture of therapeutically active C1, C1a, C2 and other minor components. Despite its decades-long use in pigs and other species, its intramuscular (IM) pharmacokinetics/pharmacodynamics (PKs/PDs) are unknown in piglets. Furthermore, the PKs of many drugs differ between healthy and sick animals. Therefore, we investigated the PKs of gentamicin after a single IM dose (10 mg/kg) in healthy piglets and piglets that were intranasally co-infected with Actinobacillus pleuropneumoniae and Pasteurella multocida (PM). The plasma concentrations were measured using validated liquid chromatography/mass spectrometry. The gentamicin exposure was 36% lower based on the area under the plasma concentration–time curve and 16% lower based on the maximum plasma concentration (Cmax) in the infected piglets compared to the healthy piglets, while it was eliminated faster (shorter half-life and larger clearance) in the infected piglets compared to the healthy piglets. The clearance and volume of distribution were the highest for the C1 component. C1, C1a and C2 accounted for 22–25%, 33–37% and 40–42% of the total gentamicin exposure, respectively. The PK/PD target for the efficacy of aminoglycosides (Cmax/minimum inhibitory concentration (MIC) > 10) could be exceeded for PM, with a greater magnitude in the healthy piglets. We suggest integrating this PK information with antibiotic susceptibility data for other bacteria to make informed antibiotic and dosage regimen selections against piglet infections. Full article
(This article belongs to the Special Issue Rational Use of Antibiotics in Veterinary Medicine)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop