Origins and Evolution of Antibiotic Resistance in the Environment

Dear Colleagues,

Antimicrobial resistance (AMR) represents one of the most significant global threats and challenges to public health faced by humanity today. Extensive research on AMR conducted worldwide has demonstrated that antimicrobial resistance is a complex issue that requires a holistic approach, integrating insights from various scientific disciplines. The crisis of AMR has been linked to the concept of "One Health," which highlights the interconnectedness of human, animal, and environmental health. The "One Health" framework underscores the necessity of investigating potential pathways for the transmission and evolution of antimicrobial resistance  across the domains encompassed within "One Health". Investigating the dynamics of antibiotic resistant bacteria—encompassing their persistence, modes of transmission, and evolutionary adaptations across diverse environments—represents a pivotal and urgent research priority. Insights gained from such studies will be instrumental in developing effective strategies to mitigate the spread of AMR in the environment.

In this Special Issue, we aim to compile inspiring works that focus on the origins and evolution of AMR in the environment, with particular emphasis on the following themes:

• Analysis of transmission pathways for antimicrobial-resistant bacteria and resistance determinants into natural environments, as well as their transfer from the environment to humans and animals.
• Persistence, variability, and evolution of clinically relevant antimicrobial-resistant pathogens in natural settings, such as surface waters and soils.
• Dynamics and ecological aspects of resistance dissemination within and between ecosystems.
• Exploratory studies uncovering bacteria and resistance determinants in underexplored or pristine environments.
• Strategies to limit the evolution and transmission of AMR through environmental vectors.

This Special Issue seeks to advance the understanding of the complex interactions driving the development and spread of AMR in environmental contexts, and also contribute to the identification of action directions for preventing further AMR progress.

Dr. Damian Rolbiecki
Dr. Małgorzata Czatzkowska
Guest Editors

Manuscript Submission Information

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• surface water
• soil
• wastewater
• antibiotic resistance genes
• antibiotic resistant bacteria
• One Health
• WHO pathogens
• anthropogenic pressure