Managing Appropriate Antibiotic Prescribing and Use in Primary Care

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics Use and Antimicrobial Stewardship".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 3423

Special Issue Editor


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Guest Editor
Department of General Practice and Primary Care, The University of Melbourne, Melbourne, VIC, Australia
Interests: primary care; general practice; antimicrobial stewardship; antimicrobial resistance; infectious disease

Special Issue Information

Dear Colleagues,

Antibiotic resistance is an international health concern. The volume of antibiotic use is the leading driver of resistance, and inappropriate prescribing is the main culprit. Most antibiotic prescribing occurs in the community, with an estimated 80% of antibiotic prescriptions being issued in primary care. Thus, it is important to manage the appropriate prescribing and use of antibiotics in primary care to tackle antibiotic resistance.

Studies have suggested that the inappropriate prescribing of antibiotics may be due to factors such as diagnostic uncertainty, physicians’ perception that patients would be more satisfied with the visit if antibiotics were prescribed, physicians’ perception that patients expect to be prescribed antibiotics for the visit, and patients’ demand for antibiotics. Recommendations from these studies included the following: (1) to encourage better communication between patients and healthcare providers, such as GPs, practice nurses, and pharmacists, in appropriate antibiotic use; (2) to provide decision aids to patients to assist with the shared decision making between the patient and the healthcare provider; and (3) to deliver patient education on infectious diseases such as respiratory tract infections (RTIs), skin and soft tissue infections (SSTIs) and urinary tract infections (UTIs), and appropriate antibiotic usage to reduce the expectation and the inappropriate use of antibiotics.

The aim of this Special Issue is to provide new insights into the management of appropriate antibiotic prescribing and use (including dispensing and self-medication) in primary care, as well as to deem what intervention strategies and ideas could assist appropriate antibiotic use in the community.  Therefore, we wish to invite original research articles and reviews that address the following topics:

  • Appropriate antibiotic management in primary care;
  • Novel interventions that increase the public awareness of antibiotic use;
  • Multi-disciplinary approaches to reduce antibiotic prescribing and use;
  • Increase public knowledge around the potential danger of self-medication, storing unused antibiotics, and the sharing of antibiotics without prescriptions;
  • Novel ideas (including practical, legal, ethical, political, and corporate) which are necessary to assist appropriate antibiotic prescribing and use in primary care.

We look forward to receiving your contributions.

Dr. Ruby Biezen
Guest Editor

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Keywords

  • primary care
  • general practice
  • antimicrobial stewardship
  • antimicrobial resistance
  • infectious disease
  • appropriate prescribing
  • guidelines concordance

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Published Papers (3 papers)

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Research

12 pages, 2288 KiB  
Article
Geo-Temporal Variation in the Antimicrobial Resistance of Escherichia coli in the Community
by Chloé C. H. Smit, Caitlin Keighley, Kris Rogers, Spiros Miyakis, Katja Taxis, Martina Sanderson-Smith, Nick Nicholas, Hamish Robertson and Lisa G. Pont
Antibiotics 2025, 14(3), 233; https://doi.org/10.3390/antibiotics14030233 - 25 Feb 2025
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Abstract
Background: Antimicrobial resistance (AMR) is a global health challenge with significant global variation. Little is known about the prevalence on a smaller geographical scale. Objectives: This study aimed to explore the geo-temporal variation in antibiotic resistance in Escherichia coli (E. coli) [...] Read more.
Background: Antimicrobial resistance (AMR) is a global health challenge with significant global variation. Little is known about the prevalence on a smaller geographical scale. Objectives: This study aimed to explore the geo-temporal variation in antibiotic resistance in Escherichia coli (E. coli) urinary isolates in the Illawarra Shoalhaven region, a region south of Sydney. Methods: Data from urine E. coli isolates from people living in the community were geospatially analysed from 2008 to 2018. The proportion of resistant isolates was mapped by antibiotic type (amoxicillin with clavulanic acid, cefalexin, norfloxacin, and trimethoprim), postcode, and year. Results: Resistance varied by antibiotic, postcode, and over time, with some postcodes showing increased resistance one year and a decrease the following year. Areas with consistently higher resistance included metropolitan, port, and lake regions. We found low resistance in E. coli to amoxicillin with clavulanate, cefalexin, and norfloxacin (<5% to 10–19%) and the highest resistance for trimethoprim (10–19% to 30–39%). Overall, from 2008 to 2018, E. coli resistance to all four antibiotics increased in this region. Conclusions: This study shows temporal and geospatial changes in E. coli AMR over small geospatial areas, indicating the opportunity for geospatial analysis to assist in area-specific empirical treatment guidance. Full article
(This article belongs to the Special Issue Managing Appropriate Antibiotic Prescribing and Use in Primary Care)
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16 pages, 254 KiB  
Article
Factors Influencing Antibiotic Prescribing and Antibiotic Resistance Awareness Among Primary Care Physicians in Poland
by Karolina Świder, Mateusz Babicki, Aleksander Biesiada, Monika Suszko, Agnieszka Mastalerz-Migas and Karolina Kłoda
Antibiotics 2025, 14(2), 212; https://doi.org/10.3390/antibiotics14020212 - 19 Feb 2025
Cited by 1 | Viewed by 1211
Abstract
Introduction: Antibiotic resistance is a major public health problem in Europe. Most antibiotics are sold only by prescription in Poland, and it is mainly up to physicians to decide whether to start antibiotic treatment. Therefore, we analyzed the factors influencing the prescribing [...] Read more.
Introduction: Antibiotic resistance is a major public health problem in Europe. Most antibiotics are sold only by prescription in Poland, and it is mainly up to physicians to decide whether to start antibiotic treatment. Therefore, we analyzed the factors influencing the prescribing of antibiotics for upper respiratory tract infections by primary care physicians in Poland, attitudes toward antibiotic resistance, and knowledge of the principles of antibiotic use. Methods: We conducted a CAWI (Computer-Assisted Web Interview) survey, carried out using a proprietary survey distributed online. Results: A total of 528 doctors participated in the study. The result of the physical examination and additional tests, as well as the recommendations of scientific societies are the most important in deciding whether to start antibiotic therapy. Patient pressure (p < 0.011) and workload (p = 0.021) significantly influenced the decision to prescribe an antibiotic among primary care physicians and physicians in the course of specialization, who fear of legal consequences (p < 0.001). The habits of other physicians (p < 0.001) working at the same facility appeared to be additionally important. Conclusions: The decision to implement antibiotic therapy in upper respiratory tract infections is influenced by several factors that depend on the doctor (including place of work and seniority) and the patient (clinical symptoms, expectation of antibiotic prescription). The physician’s level of knowledge contributes to reducing antibiotic prescribing. Considering the factors associated with the level of knowledge and awareness, together with a high prevalence of self-medication with antibiotics in Polish population, there is a strong need to design educational interventions aimed at reducing inappropriate antibiotic prescribing and preventing antibiotic resistance in Poland. Full article
(This article belongs to the Special Issue Managing Appropriate Antibiotic Prescribing and Use in Primary Care)
11 pages, 751 KiB  
Article
Temporal Trends of Escherichia coli Antimicrobial Resistance and Antibiotic Utilization in Australian Long-Term Care Facilities
by Chloé Corrie Hans Smit, Caitlin Keighley, Kris Rogers, Spiros Miyakis, Katja Taxis, Hamish Robertson and Lisa Gail Pont
Antibiotics 2025, 14(2), 208; https://doi.org/10.3390/antibiotics14020208 - 18 Feb 2025
Viewed by 854
Abstract
Background/Objectives: Antimicrobial resistance (AMR) is a global problem with antibiotic consumption considered a key modifiable factor for the development of AMR. Long-term care (LTC) facilities have been identified as potential reservoirs for Escherichia coli (E. coli) resistance due to high rates [...] Read more.
Background/Objectives: Antimicrobial resistance (AMR) is a global problem with antibiotic consumption considered a key modifiable factor for the development of AMR. Long-term care (LTC) facilities have been identified as potential reservoirs for Escherichia coli (E. coli) resistance due to high rates of urinary tract infection (UTI) and high levels of antibiotic consumption among residents. However, while the relationship between these two factors is well accepted, little is known about the possible temporal relationship between these. This study explores trends in E. coli resistance and antibiotic consumption in LTC focused on potential temporal relationships between antibiotic utilization and AMR. Methods: A retrospective, longitudinal, and ecological analysis was conducted between 31 May 2016 and 31 December 2018. The primary outcomes were the monthly prevalence of E. coli AMR in urine isolates and the monthly percentage of residents using an antibiotic recommended for the management of UTI in national treatment guidelines (amoxicillin, amoxicillin with clavulanic acid, cefalexin, norfloxacin, and trimethoprim). Results: During the study period, 10,835 urine E. coli isolates were tested, and 3219 residents received one or more medicines and were included in the medicines dataset. Over one-quarter were resistant to at least one of the target antibiotics (23.3%). For most antibiotics, the temporal relationship between AMR and antibiotic utilization was unclear; however, potential patterns were observed for both trimethoprim and amoxicillin with clavulanic acid. Trimethoprim showed a temporal decrease in both AMR and utilization, while amoxicillin with clavulanic acid showed a lag time of approximately four months between utilization and resistance. Conclusions: The dynamic nature of AMR demonstrated in this study highlights the need for more up-to-date local surveillance to inform antibiotic choice in this setting. Full article
(This article belongs to the Special Issue Managing Appropriate Antibiotic Prescribing and Use in Primary Care)
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